Protein Alignment ACXD and Gucy2g

DIOPT Version :9

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001074545.1
• Gene: Gucy2g / 73707
• MGIID: 106025
• Length: 1100
• Species: Mus musculus
• Alignment Length: 1285
• Identity: 232/1285 - (18%)
• Similarity: 421/1285 - (32%)
• Gaps: 419/1285 - (32%)

  Fly    11 YNRSNPISLARTSSQAQTVQNEKN----------WEWSYLVRKCRNLELEDSYDLYMRRLRVGYL 65
            :|.|:|.|:.|..:..|||.::.|          ||::|....|   ..::|..:::.:::..::
Mouse    54 WNISHPFSVQRLGAGLQTVVDKLNSEPVGLGNVSWEFTYTNSTC---SAKESLAVFIDQVQKEHI 115

  Fly    66 S------------------------LFIFI-HVAVTVIH----TLLLLTTP--EIKYVYVDMVAY 99
            |                        ||.|: .:|....|    |.:.|..|  ||..|..:.:.|
Mouse   116 SALFGPACPEAAEVIGLLASEWNIPLFDFVGQMAALKDHFWCDTCVTLVPPKQEISAVLRESLRY 180

  Fly   100 MCSGLVIWVVLGVNFRSELVSKHGWVVYATSWLAV--CVMVLMDIGLNVYHATSHNDILNPIYDA 162
            :.     |..:||...|...|  .|......|.||  .:....:|..::.:.:|.:|:|..
Mouse   181 LG-----WEHIGVFGGSSADS--SWEQVDEMWGAVEDGLQFHFNITASMRYNSSSSDLLQE---- 234

  Fly   163 YTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAIYLSCVNLLGIFF 227
                                  ......|:.....:|.:.:|  ...||..|:.|.......:|.
Mouse   235 ----------------------GLRNMSYVARVIILICSSED--ARRILQAAVDLGLDTGEFVFI 275

  Fly   228 RLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQ 292
            .|.:   |..:|.  ::.:.::.::|:.:..|...|  |.|:.....:.:|          ..::
Mouse   276 LLQQ---LEDSFW--KEVLTKDKVIRFPKVYESVFL--IAPSAYGGGIGDD----------GFRK 323

  Fly   293 QSQVDLRRSADSQTLKRWRQPDHGTLFIEPH----EDVTVLYADVVNYTHLTTTLDVKKLVEALH 353
            |...:|||.....::....|       :.|:    .|..:|||..|.        :::|..:...
Mouse   324 QVSQELRRPPFQSSITSEDQ-------VSPYSAYLHDALLLYAQTVE--------EMRKAEKDFR 373

  Fly   354 DLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNID 418
            |       ..:..:.||..     ...:.|:..|                 .:.|.:.|||::..
Mouse   374 D-------GRQLISTLRAG-----QVTLQGITGP-----------------VLLDSQGKRHVDYS 409

  Fly   419 MRIGVHSG-----------DVLSGVIGAAKWQFD---IW--------------SKDVDIANRLEA 455
            :.....||           |....||  ..|:.|   .|              ..|:........
Mouse   410 VYALQESGNRSLFLPFLHYDSFQKVI--RPWRNDSNTSWPHGSLPEYKPGCGFHNDLCKTKPPTV 472

  Fly   456 TGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLIKSLRAPMHD---------- 510
            .|.|..|.....|::.|                .:.....|...::..||..:..
Mouse   473 AGMTVTVTAVIPTVTFL----------------VLASAAAITGLMLWRLRGKVQSHPGDTWWQIR 521

  Fly   511 -------PRRRMRERQVKKLSEASKANFMHNSTLHQYNQVRNQAKLEMCRELDKMPIGRIQLTKV 568
                   |:.::..|.    :..|:.|....||:.......:..|.....||...|:|..|..:|
Mouse   522 YDSITLLPQHKLSHRG----TPVSRRNVSDTSTVKASADCGSLVKRHQDEELFFAPVGLYQGNQV 582

  Fly   569 FRRSTRLTQDE----IEEETFRRNISSCCLFFRIRNWEF-----------------QYIKE---P 609
               :.....||    :::.|.||.:   ||...:::...                 ||.|:   .
Mouse   583 ---ALCYIGDEAEAWVKKPTVRREV---CLMCELKHENIVPFFGVCTEPPNICIVTQYCKKGSLQ 641

  Fly   610 DVMLK--------YSIALAWVIYMGLLTIQLLSKDARYHYWYIDGTTIILLTMLLIVS----W-- 660
            |||..        :.::.|:.|..|||.:.  ....|.|........::...|.|.:|    |
Mouse   642 DVMRNSDHEIDWIFKLSFAYDIVNGLLFLH--GSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEF 704

  Fly   661 -YKKLWIMYMSDADVSSPNGRLSGFLFRM-----SDEMQRNVVIRVVMYFLIIFSYCAVAIMQVV 719
             :...|..|..:|...|.....:..|.|:     |...|.:|           :|: |:.:..::
Mouse   705 KHGSTWRSYNQEATDHSELYWTAPELLRLRESPCSGTPQGDV-----------YSF-AILLRDLI 757

  Fly   720 GCSSDEDYADLDPTYDERVQ---------CFHPWILTNCMTLVIGMSFLFTRIPFIIKSCFSALI 775
            ...:...:.||:...:|.:.         ...|.:|.:...         .||..:::.|:..
Mouse   758 HQQAHGPFEDLEAAPEEIISRIKDPRAPVPLRPSLLEDKGD---------GRIVALVRECWDE-- 811

  Fly   776 MIGYAVLVVSEFNFIYANSPSTNVNFNAKYSHILLMIITFGIFHLMERQTEFIAKVDYNWKRQLI 840
                    ..|...|:.:...| :...:...|:.::....|   .:|.....:.:|.....|:|:
Mouse   812 --------SPELRPIFPSIKKT-LREASPRGHVSILDSMMG---KLETYANHLEEVVEERTRELV 864

  Fly   841 KKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQNELYYEEYDNVAVMFASIKNFDTDKIGL-- 903
            .::.       .::.||:.:||:.|.:..::.:   .:..|.:::|.:.|:.|..| |....|
Mouse   865 AEKR-------KVEKLLSTMLPSFVGEQLIAGK---SVEPEHFESVTIFFSDIVGF-TKLCSLSS 918

  Fly   904 -----RVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLM 963
                 ::||::...||..:    ||..|.|::.....||.|.||
Mouse   919 PLQVVKLLNDLYSLFDHTI----QSHDVYKVETIGDAYMVASGL--------------------- 958

  Fly   964 PNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVV 1028
                                  |..||:..|.::
Mouse   959 ----------------------PIRNGAQHADEI------------------------------- 970

  Fly  1029 RVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNM 1093
               |..||.|:.....|...:|..|..      .||||:..|..:||||||:.|.|.::|:.|||
Mouse   971 ---ATMALHLLSVTTHFQIGHMPEERL------KLRIGLHTGPVVAGVVGITMPRYCLFGDTVNM 1026

  Fly  1094 ASRMDSTGVPGQIQVTENTA---LKLREFNIQCNYRGMTFVKGRGNIPTY 1140
            ||||:|:.:|.:|.|:::||   |....:::|  .||...|||:|...|:
Mouse  1027 ASRMESSSLPLRIHVSQSTAGALLAAGGYHLQ--KRGTISVKGKGEQTTF 1074

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	45/274 (16%)
		CYCc	254..476	CDD:214485	40/253 (16%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	31/213 (15%)
		CYCc	856..1117	CDD:214485	64/270 (24%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	67/273 (25%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595	83/482 (17%)
		PK_GC	555..829	CDD:270894	53/313 (17%)
		CYCc	865..1055	CDD:214485	64/287 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900