DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and Gucy1a1

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001343916.1	Gene:	Gucy1a1 / 60596	MGIID:	1926562	Length:	691	Species:	Mus musculus

Alignment Length:	351	Identity:	80/351 - (22%)
Similarity:	151/351 - (43%)	Gaps:	104/351 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 IINYSFVI-------TAKDDNQMHSILNEAIYL-----------SCVNLL------GIFF----- 227
            ::|..|||       :.|..:::..:..:.||:           .||:.|      |::.
Mouse   341 MLNMQFVIRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPI 405

  Fly   228 -RLMRDIA------------------LRTTFLDRRQYVEENLLLRYARDQERS--LLLSILPAQI 271
             ..:||:.                  |:.|.....|.:||        :::|:  ||.||.|:::
Mouse   406 HNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEE--------EKKRTVDLLCSIFPSEV 462

  Fly   272 ADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNY 336
            |.:|.:   .:|.::|:                                  ..:||:|::|:|.:
Mouse   463 AQQLWQ---GQIVQAKK----------------------------------FSEVTMLFSDIVGF 490

  Fly   337 THLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNAD-HAKCCVDLGL 400
            |.:.:.....:::..|:.|:.|||....|.:|.:::.:||. |||||..:..:| ||.....:.|
Mouse   491 TAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YCVAGGLHRESDTHAVQIALMAL 554

  Fly   401 RMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVS 465
            :|::...:|.......|.||||:|||.|.:||:|....::.::..:|.:||:.|:.....:::||
Mouse   555 KMMELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVS 619

  Fly   466 QKTLSLL---DGEYFFEDGTEKARED 488
            ..|..||   .|..|    |.::||:
Mouse   620 PTTYRLLKDCPGFVF----TPRSREE 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	26/141 (18%)
		CYCc	254..476	CDD:214485	58/227 (26%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	52/172 (30%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
Gucy1a1	NP_001343916.1	HNOBA	277..466	CDD:311573	25/132 (19%)
Gucy1a1	NP_001343916.1	Guanylate_cyc	472..643	CDD:306677	53/209 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900