DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and gucy2ca

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_009297342.1	Gene:	gucy2ca / 572052	ZFINID:	ZDB-GENE-091118-67	Length:	1025	Species:	Danio rerio

Alignment Length:	977	Identity:	194/977 - (19%)
Similarity:	301/977 - (30%)	Gaps:	398/977 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 DCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDV-----REKRHLNIDMRIGVHSGDVLSGVIGA 435
            :|::.:..|..|:|..:.   ::...|::...::     |:.||.||.:..|...
Zfish   198 ECFWYINALEAPSALFSS---NISREMLRSESELSTALKRKDRHSNIIVMCGTPD---------- 249

  Fly   436 AKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFL 500
                 ||:            |........||....|:|                 |...|.||
Zfish   250 -----DIY------------TIKKNNTVPSQVVFILID-----------------LYNEGYRT-- 278

  Fly   501 IKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTLHQYNQVR--NQAKLEMCRELDKMPIGRI 563
              :..:|.|       .|.|..|:..|..|:..||.......|.  ...||:...:.| :.:..:
Zfish   279 --NESSPAH-------MRNVLVLTMHSFRNYSSNSVWRNNTTVSIGGYYKLDSSGDRD-LNLSVV 333

  Fly   564 QLTKVFRRSTRLTQDEIEEETFRRNISSCCLFFRIR-------NWEFQYIKEPDVMLKYSIALAW 621
            ..|..::..|..:.|..:..|..::.|....:.|.:       ..|.|.|..  ::|..|:.||.
Zfish   334 YTTGSYKYRTLFSFDTSQNRTKVKDSSPDLPWDRSQLPRDKHTGMEIQEIMM--IVLGLSVVLAT 396

  Fly   622 VIYMGL----------------------------------LTI--------QLLSKDARYHYWYI 644
            ||...|                                  |||        ..|.:..||
Zfish   397 VIAFILYRQNRRVRFDQKKWSHISSSLITPLDDKERNYISLTIDEDKKGDNSSLIRKGRY----- 456

  Fly   645 DGTTIIL-----------------LTMLLIVSWYK--KLW--------------------IMYMS 670
            |...:||                 |..||.:.:|.  |.:                    :.|:.
Zfish   457 DKKPVILKELRNTDGNFTDDQRIELNALLRIDYYNLTKFYGTVRFDCGVFGVFEFCERGSLRYVL 521

  Fly   671 DADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLII-FSY----------------CAVAIMQV 718
            |..:|.|:.......||:|           |||.:.. .||                |.|....|
Zfish   522 DDKISYPDASFMDLEFRIS-----------VMYDIAKGMSYLHSSNVGVHGRLKSTNCVVDNRMV 575

  Fly   719 V-----GCSSDEDYADLDPTYDERVQCFHPWILTNCMTL-------------VIGMSFLFTRIPF 765
            |     ||::     .|.|..|       .|.....|.:             :|....:..:.||
Zfish   576 VKITDFGCNT-----ILSPGKD-------LWTAPEHMRVEGISQKGDVYSFAIISQEIILRKSPF 628

  Fly   766 IIKSC---FSALIMIGYA-----------------------VLVVSEFNFIYANSPSTNVNF--- 801
            ....|   ...|.::.|.                       ||:.|    .:...|....:|
Zfish   629 HTSCCSDMAEKLYLVQYPRGPNVFRPDLSFEGVGETEAELFVLIKS----CWEEDPEKRPDFKRI 689

  Fly   802 ---------------NAKYSHIL---LMIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALI 848
                           ||.|...|   |.:.:..:.||:|.:|            .|.|.:.|..
Zfish   690 EGALGKIFSNLHNQANASYMDNLIRRLQMYSRNLEHLVEERT------------ALYKAERDRA- 741

  Fly   849 TNDTIKVLLTNILPTHVA-DFYLSNQLQNELYYEEYDNVAVMFASIKNF------DTDKIGLRVL 906
              |.:..:|   ||..|. ....:.:::.||    ||.|.:.|:.|..|      .|....:.:|
Zfish   742 --DQLNFML---LPGPVVRSLKETGRVEPEL----YDEVTIYFSDIVGFTTICHHSTPMEVVDML 797

  Fly   907 NEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRY 971
            |:|..:||.:|:.:.    |.|::.....||.|.||
Zfish   798 NDIYKNFDSILDHHD----VYKVETIGDAYMVASGL----------------------------- 829

  Fly   972 DGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFAL 1036
                          |..||:..|:|:.|                                  .||
Zfish   830 --------------PRCNGNRHAVDICL----------------------------------MAL 846

  Fly  1037 DLMRTMRRFNTENMQTEYEGSTDYGM---LRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMD 1098
            |::..|..|...::.         |:   :||||..|...|||||...|.|.::|:.||.||||:
Zfish   847 DILEFMGTFQLRHLP---------GIPLWIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTASRME 902

  Fly  1099 STGVPGQIQVTENT--ALKLREFNIQCNYRGMTFVKGRGNIPTY-IIGIDSEYQFLPHRPAAPTK 1160
            |||:|.:|.|:|:|  .|:..:...:|..||.||:||:|...|| :.|:..:...|   |..||.
Zfish   903 STGLPLRIHVSESTIKILQRTDCEFECERRGETFLKGKGKEMTYWLTGVTGQKYSL---PTPPTV 964

  Fly  1161 ED 1162
            |:
Zfish   965 EN 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831
		CYCc	254..476	CDD:214485	18/104 (17%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	22/131 (17%)
		CYCc	856..1117	CDD:214485	66/272 (24%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	71/275 (26%)
gucy2ca	XP_009297342.1	Periplasmic_Binding_Protein_Type_1	31..365	CDD:299141	40/225 (18%)
		PKc_like	428..698	CDD:304357	48/301 (16%)
		Pkinase_Tyr	451..689	CDD:285015	44/269 (16%)
		CYCc	736..929	CDD:214485	68/292 (23%)
		Guanylate_cyc	763..950	CDD:278633	72/280 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000