Protein Alignment ACXD and adcy3a

DIOPT Version :9

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_009290286.1
• Gene: adcy3a / 571825
• ZFINID: ZDB-GENE-111027-6
• Length: 1119
• Species: Danio rerio
• Alignment Length: 1247
• Identity: 339/1247 - (27%)
• Similarity: 538/1247 - (43%)
• Gaps: 335/1247 - (26%)

  Fly    49 LEDSYDLYMRRLR-------VGYLSLF-IFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSGLV 105
            ||:.|..|.||.|       |.:.:|| .:|.|..||::|...|.:          ||....||.
Zfish    62 LENLYQTYFRRQRHETLLVLVVFAALFDCYIIVMCTVLYTADKLAS----------VAVASVGLA 116

  Fly   106 IWVVLGVNFRSELVSKHG---------WVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYD 161
            ..|:|      .|:.::|         .|.||. |:.:...:...:|||.......:|.:.  :.
Zfish   117 ADVLL------YLLCRYGLLPDRVTRRLVPYAL-WVLIAAQIFCYLGLNFARFHQPSDTVG--WQ 172

  Fly   162 AYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQ---------MHSILNEAIYL 217
            |:  ::...|:.:|..|.|.||.::|: |.:......:|.....|         ...:.|..||:
Zfish   173 AF--FSFSFFLTLPLRLTPIVLITSVS-CGVHTLVLGVTIAQQQQEDIQGAALGRQLLANMVIYV 234

  Fly   218 SCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNR 282
             |...:|:....|.|...|..||:.||.:|..|.|.....|:..|||||||..|||.:.:|:|.
Zfish   235 -CAITVGVMSYYMADRKHRKAFLEARQSLEVKLNLEEQSQQQERLLLSILPKHIADEMLQDMKK- 297

  Fly   283 IERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKK 347
             |.|:::.||                      ..|:::..||:|::|:||:|.:|.|:::...::
Zfish   298 -EASQKEMQQ----------------------FNTMYMYRHENVSILFADIVGFTQLSSSCSAQE 339

  Fly   348 LVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREK 412
            ||:.|::||.|||..:.:|:.||||.|||||||:.||.:...|||.|.:.:||.|::.|..||||
Zfish   340 LVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAACSIMMGLAMVEAISYVREK 404

  Fly   413 RHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYF 477
            ...::|||:|||||.||.||:|..:||:|:||.||.:||::||.|..||||:||.||..|.||:.
Zfish   405 TQTDVDMRVGVHSGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQNTLECLHGEFD 469

  Fly   478 FEDGTEKAREDPVLQKHGIRTFLIKSLRAP--------------------------------MH- 509
            .|.|....|.: .|::.||.|:|:...:.|                                :|
Zfish   470 VEPGNGGDRCE-YLKERGIETYLVVLPKGPVGKNGINGVKLSVTSSNGNSPLLINTTECNGSVHT 533

  Fly   510 ---------------------DPRRRMRERQV-KKLSEASKANFMHNSTLHQYNQVRNQAKLEMC 552
                                 :||||:|.|.: :::.:|.:..       .:.|::.|:|.||
Zfish   534 ACTTPEDPEELDTRVVNPSFPNPRRRLRLRDLAERVIDAQENE-------QELNKLLNEALLE-- 589

  Fly   553 RELDKMPIGRIQLTK---VFRRSTRLTQDE------IEEETFRRNISSCCLFFRIRNWEFQYIKE 608
            ||       .:|..|   ..|.|.|.|..|      :|:|.......||.....:.....:.:.:
Zfish   590 RE-------TVQALKGKYTNRLSLRFTDPELETRFSVEKEKQSGAAFSCSCVVLLFTAVMEALID 647

  Fly   609 PDVMLKY-SIALAWVIYMGLLTIQLLS---------KDARYHYWYIDGTTIILLTMLLIVSWYKK 663
            |.::..| ::|:..|:.: :|||..|:         :...:..| ||.|           .|.:.
Zfish   648 PWLVANYVTLAVGEVLLL-ILTICSLAAIFPRVFPKRLVSFSTW-IDHT-----------RWARN 699

  Fly   664 LWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIFSYC---------AVAIMQVV 719
            .|.|             .:.|:..::|              ::....|         :.|:..||
Zfish   700 TWAM-------------AAIFIVTLAD--------------IVDMLSCRAPQTSTVESTAVPPVV 737

  Fly   720 ----GCSSDEDYADLDPTYDERVQCFHPWILTNCMTLVIGMSFLFTRIPFIIKSCFSALIMIGYA 780
                ||:.:..|...                  ...|.:..:.:..::..::|  .:.:::|..|
Zfish   738 TAIRGCAENPKYYSF------------------IAVLALIATTMLVQVSHMVK--LTLMLLITVA 782

  Fly   781 VLVVSEFNF-----IYANSPSTNVNFN---AKYSHILLMIITFGIFHLMERQTEFIAKVDYNWKR 837
            ...|:.:::     :|..:.......|   :||:..:::.|....|:...|..|.:|:..:.||.
Zfish   783 TGAVNIYSWSQTFDLYDLTRFKEYRVNLVPSKYTMSVMIFIMMVSFYYFSRHVEKLARTLFLWKI 847

  Fly   838 QLIKKQEDALITNDTIKVLLTNILPTHVADFYL-SNQLQNELYYEEYDNVAVMFASIKNFD---- 897
            ::.:::|.........:.|:||:||.|||..:| |.:...|||.:.||.:.||||||.||.
Zfish   848 EVHEQKEKVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASIPNFSDFYT 912

  Fly   898 TDKIG------LRVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNA-PQM 955
            .:.|.      ||.|||||.|||.:|:: .|...:.|||....|||||.|  |:.....|. ..|
Zfish   913 EESINNGGIECLRFLNEIISDFDSLLDE-PQFRCITKIKTIGSTYMAASG--VTSDNNTNGYACM 974

  Fly   956 KFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHN 1020
            |...:|                                    |.||.|:..:
Zfish   975 KKEEIS------------------------------------DRERWQHLAD------------- 990

  Fly  1021 GSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYD 1085
                      :|:|||.:..|:...|       |:...:: |||||::.|..:|||:|..|||:|
Zfish   991 ----------LADFALAMKVTLMNIN-------YQSFNNF-MLRIGLNKGAVLAGVIGARKPHFD 1037

  Fly  1086 IWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVKGRGNIPTYIIG------- 1143
            ||||.||:||||:||||.|.|||.|:....|:::..:...||..||||:|.:.||.:.
Zfish  1038 IWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYGFRFVRRGPIFVKGKGELLTYFLKGREKQGS 1102

  Fly  1144 -IDSEYQFLPHR 1154
             |:..:..|||:
Zfish  1103 FINGSFVTLPHQ 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	71/260 (27%)
		CYCc	254..476	CDD:214485	96/221 (43%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	87/181 (48%)
		CYCc	856..1117	CDD:214485	94/272 (35%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	93/274 (34%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831	73/266 (27%)
		CYCc	273..468	CDD:214485	96/218 (44%)
		Guanylate_cyc	310..492	CDD:278633	86/182 (47%)
		CYCc	858..1075	CDD:214485	95/286 (33%)
		Guanylate_cyc	889..1096	CDD:278633	93/276 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810