Protein Alignment ACXD and adcy1b

DIOPT Version :9

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001161822.1
• Gene: adcy1b / 569499
• ZFINID: ZDB-GENE-100805-1
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1037
• Identity: 301/1037 - (29%)
• Similarity: 479/1037 - (46%)
• Gaps: 225/1037 - (21%)

  Fly   176 YLLQPFVLGSAVTFCYIINYSFVI----TAKDDNQ--MHSILNEAIYLSCVNLLGIFFRLMRDIA 234
            |.|.|...|.|:.|..::..:..:    |..|:.|  ..|::...:..:.||:.|:|.|::.:.|
Zfish   152 YCLLPVRTGLALLFGLLLPLAHTLITASTLPDNTQRLWRSLVANTLLFTGVNVSGLFVRILTERA 216

  Fly   235 LRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLR 299
            .|..||..|..:||.|.:....:::..||:|:||..:|..::||.....||...:
Zfish   217 QRKAFLQARNCIEERLRMEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHK---------- 271

  Fly   300 RSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASE 364
                              ::|:.|::|::|:||:|..|.|.:....::||:.|::||.:||..:.
Zfish   272 ------------------IYIQRHDNVSILFADIVGSTSLASQCTAQELVKLLNELFGKFDELAT 318

  Fly   365 EYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVL 429
            |.:..|||.||||||||:||..|..|||.|||::||.||..|..|.|...::::||:|:|:|.||
Zfish   319 ENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVL 383

  Fly   430 SGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKH 494
            .||:|..|||:|:||.||.:||.:||.|..|:||:::.||..|:|:|..|.|..:.|. ..|.||
Zfish   384 CGVLGLRKWQYDVWSNDVTLANMMEAGGLPGKVHITRSTLECLNGDYEVEPGNGRERH-AFLLKH 447

  Fly   495 GIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNST----LHQYNQVRNQAKLEM---- 551
            .|.||.|    .|.|  ||::....:  ||:...|..|...|    |.|....|...:.|:
Zfish   448 DIETFFI----VPPH--RRKIFPGLI--LSDIKPAKKMKFKTVCYLLVQLMHCRKMFRAEIPFSN 504

  Fly   552 ---CRELDKMPIGRIQLTKVFRRS------------TRLTQ------DEIEEETFRRNISSCCLF 595
               |.:.||..:.|....|:..|:            ||:.:      :..:.|:...:::...|.
Zfish   505 VMNCEDGDKRRVLRSAPEKLRNRTPTAASAPQSSPGTRVNRYINRLIEARQTESDTADLNYLTLM 569

  Fly   596 FRIRNWEFQYIKEPDVMLKYSIALA--WVIYMGLLTIQLLSKDARYHYWYIDGTTIILLTMLLIV 658
            :|....|.:|.:..|.....::.|:  .|:.:|.|.:.::.:          ||.:::|.:..|.
Zfish   570 YRDSERERRYHQLNDEYFTGAVVLSLLLVVLLGFLYLLIIPQ----------GTVVLVLLVFCIC 624

  Fly   659 SWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGC-- 721
              :..:.|||:....|....|.|:             :.||..:...|:....|||...||||
Zfish   625 --FLVVCIMYLHITRVQCFPGCLT-------------IQIRTALCVFIVLLIYAVAQACVVGCMP 674

  Fly   722 ----SSD-------EDYADLDPTYDERVQCFHPWILTNCMTLVIGMSFLFTRIPFIIKSCFSALI 775
                |:.       :..|.|:.|..|.......:....||...:.|: ||.|:.:|.|:....|:
Zfish   675 WLWPSNSTRSIVIIDAAAGLNRTMAELPCAGAQYAFLCCMLGTLSMA-LFLRVSWIPKTILLLLL 738

  Fly   776 MIGY-AVLVVSEFNFIYANSPSTNVNFNAKYSHILLMIITFG-IFHLMERQTEFIAKVDYNWKRQ 838
            ::.| .:|.:|.|     ...|.....:.:....||.::.|. ...|..||.:...::|:.|..|
Zfish   739 LVLYITILELSGF-----RRASGWALLSVRGLEPLLSLLLFSTAVALHSRQLDLKLRLDFLWATQ 798

  Fly   839 LIKKQEDALITNDTIKV----LLTNILPTHVAD-FYLSNQLQNELYYEEYDNVAVMFASIKNF-- 896
             .:::.|.:   :.:|:    :|.|:||.|||. |.|||....:|||:.|..|.|:||||.||
Zfish   799 -AEEERDGM---EKVKLDNKRILFNLLPVHVAQHFLLSNPRNMDLYYQSYAQVGVLFASIPNFND 859

  Fly   897 -----DTDKIG---LRVLNEIICDFDDVLNK--YSQSLRVEKIKVANWTYMAACGLDVSRSEQVN 951
                 |.:.:|   ||:|||||.|||::::|  |..   :||||....|||:|.||
Zfish   860 FYIELDGNNMGVECLRLLNEIIADFDELMDKECYKD---IEKIKTIGSTYMSAVGL--------- 912

  Fly   952 APQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRIS 1016
                                             ||                    .:.|...:.:
Zfish   913 ---------------------------------VP--------------------TIGTKAKKST 924

  Fly  1017 STHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISK 1081
            :||        :..:|:||:::...:...|       |:...|: :||:||:.|..:|||:|..:
Zfish   925 ATH--------LSTIADFAIEMFDVLDEIN-------YQSYNDF-VLRVGINVGPVVAGVIGARR 973

  Fly  1082 PHYDIWGNPVNMASRMDSTGVPGQIQVTENT-ALKLREFNIQCNYRGMTFVKGRGNIPTYII 1142
            |.||||||.||:|||||||||||:|||||:. .|....:::.|  ||...|||:|.:.||.:
Zfish   974 PQYDIWGNTVNVASRMDSTGVPGKIQVTEDVYRLLQNNYDLMC--RGNVSVKGKGQMLTYFL 1033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	31/113 (27%)
		CYCc	254..476	CDD:214485	84/221 (38%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	84/181 (46%)
		CYCc	856..1117	CDD:214485	93/274 (34%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	91/276 (33%)
adcy1b	NP_001161822.1	AC_N	<128..270	CDD:292831	33/117 (28%)
		CYCc	236..431	CDD:214485	84/222 (38%)
		Guanylate_cyc	272..454	CDD:278633	84/182 (46%)
		DUF1053	498..585	CDD:283888	14/86 (16%)
		CYCc	806..1012	CDD:214485	94/289 (33%)
		Guanylate_cyc	839..1035	CDD:278633	91/278 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810