Protein Alignment ACXD and adcy7

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_021333246.1
• Gene: adcy7 / 568726
• ZFINID: ZDB-GENE-040713-1
• Length: 1119
• Species: Danio rerio
• Alignment Length: 1231
• Identity: 347/1231 - (28%)
• Similarity: 552/1231 - (44%)
• Gaps: 291/1231 - (23%)

  Fly    64 YLSLFIFIHVAVTVIHTLLLL-----TTPEIKYVYVDMV-AYMCSGLVIWVV-----LGVNFRSE 117
            |....:.:.:::....|||:|     ...:...::|.:| ..:|..|.::|:     |...:|:.
Zfish    29 YRQFVLLLGLSIVTCATLLVLFFSFKLKAQNHGIFVGVVGGALCLFLAVFVLVCTETLSQRWRTL 93

  Fly   118 LVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPFV 182
            |    |..|:||.         :.:|.....:|..:..:.| :|....: :::.:.| |.:.||.
Zfish    94 L----GLGVWATH---------LTMGFTFIFSTKSDLQIQP-WDQVPFF-LFIIITV-YTMLPFQ 142

  Fly   183 LGSAVTFCYIINYSFVITAK---DDNQMHS------ILNEAIYLSCVNLLGIFFRLMRDIALRTT 238
            :..||....|.:.|.:|...   ...|:||      :|:.|:...|..::|||.:::.:.||:.|
Zfish   143 MSYAVILSIISSLSHIIVLSVYLTVAQLHSNPITFQLLSNAVVFGCGIMVGIFHKVLMEKALKQT 207

  Fly   239 FLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSAD 303
            |.|..:.:...:.|...:.|:.:||.|:||..|:.:::..:..|. :.|.:.:||..|
Zfish   208 FQDTLRCLGIRMKLEIEKRQQENLLQSVLPVYISMKMKLAIMERC-KCKDKEEQQRMV------- 264

  Fly   304 SQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNV 368
                   |..:..:|:::.||:|::||||:|.:|.|.:....|:||..|::||.:||..::|...
Zfish   265 -------RDNNFHSLYVKRHENVSILYADIVGFTRLASDCSPKELVLMLNELFGKFDQIAKENEC 322

  Fly   369 LRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVI 433
            :|||.||||||||:||.....:|||.||.:||.|.:.|:.|||...::|:||:|||||:||.|||
Zfish   323 MRIKILGDCYYCVSGLPVSLPNHAKNCVKMGLDMCEAIKQVREATGVDINMRVGVHSGNVLCGVI 387

  Fly   434 GAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRT 498
            |..|||||:||.||.:||.:|:.|..||||:::.||..|:..|..|:|....| |..|::..|:|
Zfish   388 GLRKWQFDVWSHDVTLANHMESGGLPGRVHITEATLKHLNKAYEVEEGNGHLR-DTYLKELNIKT 451

  Fly   499 FLI-------KSLRAP-MHDPRRRMRERQVKKLSEASK--ANFMHNSTLHQYNQVRNQAKLEMCR 553
            ||:       .||.|| :..||          :|:..|  |:......|..:..|:..|.|:...
Zfish   452 FLVIDPRSKDSSLMAPSITKPR----------VSDGLKMRASVRMTRFLESWGAVKPFAHLQSRE 506

  Fly   554 EL--DKMPIGR-----IQLTKVFRRSTRLTQDEIEE---------ETFRRN-------------- 588
            |.  |.|..|:     |.|..|...:.....:.:||         .|:.||
Zfish   507 EFNTDAMVNGKGHCKDIPLRSVPTHNPDSFDESLEEPFSLPAPPLSTYNRNKSQKTKFDEELHDK 571

  Fly   589 -------------------ISSCCLFFRIRNWEFQY--IKEPDVMLKYSIALAWVIYMGLLTIQL 632
                               ||...|:|..::.|.||  |:.|:  .||.|..|..|::.:..||:
Zfish   572 MTTTINDLSSSKQWVKSEEISGLTLWFTKKDLEMQYRTIEMPN--FKYYIGCATFIFICIFIIQM 634

  Fly   633 LSKDARYHYWYIDGTTIILLTMLLIV----------SWYKKL----WIMYMSDADVSSPNGRLSG 683
            |....|.....  |..::...:|||:          .:.:||    |::.:|.|.|..|
Zfish   635 LVTKQRIELGL--GFAVLACFLLLILCICFADHIQRMFPEKLKSCTWLLALSKAVVKRP------ 691

  Fly   684 FLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGCSSDEDYADL--------DPTYDERVQC 740
            |:..:...:...|::.:.|:.|.:              ...::..||        |...|| :|
Zfish   692 FVRILLATVATTVIVVIAMFELFL--------------KKTDNLCDLLQQNSSFADSARDE-LQ- 740

  Fly   741 FHPWILTNCMTLVIGMSFLFTRIPFIIKSCFSALI-MIGYAVLVVSEFN-------FIYAN---S 794
            :.|:::.||:..:|... :|.|:.|.:|..|..:: ::.|.:::.|:.|       .:|.|   .
Zfish   741 YLPYLVYNCILALIACG-VFLRVSFELKLAFLLIVSLVSYTIILYSQENLFSNYNCLLYTNHSCG 804

  Fly   795 PSTNVNFNAKYSHILLM---IITFGIFH--LMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIK 854
            .|..|.......|..:|   .||..:|.  |:.||.|:..:.|:..|.:.:..:|:..:..:..:
Zfish   805 DSLMVCKAGLMKHPKIMSCIYITLFLFTMLLISRQNEYCCRQDFLLKNKNLADKEEVELCENLNR 869

  Fly   855 VLLTNILPTHVADFYLSNQLQNE----------------LYYEEYDNVAVMFASIKNF------- 896
            :||.|:||.|||..::....:||                |||:.||.|.|||||:.:|
Zfish   870 LLLENVLPAHVAALFVGENKKNEVGLLSAISLLNRKYKDLYYKSYDCVCVMFASVPDFKEFYTEC 934

  Fly   897 DTDKIG---LRVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFR 958
            |.:|.|   ||:|||||.|||::|:|...| .|||||....|||||.||
Zfish   935 DINKEGLECLRLLNEIIADFDELLSKPKFS-GVEKIKTIGSTYMAAAGL---------------- 982

  Fly   959 NVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSS 1023
                                                                |||...|..:...
Zfish   983 ----------------------------------------------------SGPPEQSNQDRER 995

  Fly  1024 SNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWG 1088
            .|..:..|.|||:.|:..:...|..:..|        ..||:||:||..:|||:|..||.|||||
Zfish   996 QNAQIGNMVEFAIALIGKLDGINRHSFNT--------FRLRVGINHGPVIAGVIGARKPQYDIWG 1052

  Fly  1089 NPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVKGRGNIPTYIIGIDSEYQ 1149
            |.||:||||:|||..|:|||||.|::.|:.....|..||:..|||:|.:.|:.:..||..|
Zfish  1053 NTVNVASRMESTGELGKIQVTEETSIVLQNLGYSCECRGLINVKGKGELKTFFVCTDSSKQ 1113

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	53/239 (22%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	88/188 (47%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	95/273 (35%)
adcy7	XP_021333246.1	AC_N	<129..248	CDD:318454	31/119 (26%)
		Guanylate_cyc	272..455	CDD:425528	89/183 (49%)
		Adcy_cons_dom	487..615	CDD:461877	25/129 (19%)
		Guanylate_cyc	909..1106	CDD:425528	95/273 (35%)