Protein Alignment ACXD and adcy3b

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_068071803.1
• Gene: adcy3b / 564719
• ZFINID: ZDB-GENE-041014-276
• Length: 1071
• Species: Danio rerio
• Alignment Length: 1201
• Identity: 327/1201 - (27%)
• Similarity: 530/1201 - (44%)
• Gaps: 278/1201 - (23%)

  Fly    49 LEDSYDLYMRRLRVGYLSLFI--------FIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSGLV 105
            ||..|..|..|.|...|.:.|        ::.:...|:::...|.|          :|....||.
Zfish    49 LEKIYQTYFLRQRQETLLVLIVFAALFNGYVIIMCAVVYSPDKLNT----------LAVAAGGLA 103

  Fly   106 IWVVLGVNFRSELVSKH---GWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYA 167
            ..::|.:..|..|:..|   ..|.||. ||.:.|.||....||.....:..|.:.  :..:.:::
Zfish   104 SDILLYITSRFRLLPVHVSACLVPYAL-WLLIMVHVLCYFSLNFAGFYAAGDTVG--WQTFFIFS 165

  Fly   168 IYMFMPVPYLLQPFVLGSAVTFC-YIINYSFVITAKDDNQMH-SIL------NEAIYLSCVNLLG 224
            .::.:|:|  |.|.||.|..:.| :.:...|.|:.::.:::. |:|      |..:|...: |:|
Zfish   166 FFLTLPLP--LAPIVLLSVFSCCAHTLLLGFTISLRNQDKLQLSVLIRQLVANLMLYFGAM-LVG 227

  Fly   225 IFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQ 289
            :....|.|...||.||:.:|.:|.:|.|:....|:..|||||||..|||.:.:.:|      |..
Zfish   228 VMSYFMADRKYRTAFLEAKQSLEVSLTLKEQSQQQEELLLSILPKHIADEMLQGMK------KGA 286

  Fly   290 HQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHD 354
            :|:         .|:|        ...|:::..||||::|:||:|.:|.|::.:..|:||:.|::
Zfish   287 NQK---------TDAQ--------QFNTMYMYRHEDVSILFADIVGFTQLSSAVTPKELVKVLNE 334

  Fly   355 LFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDM 419
            ||.|||..:.:::.||||.|||||||:.||.:...|||.|.:.:||.|::.|..||||....:||
Zfish   335 LFARFDKLAAQHHQLRIKILGDCYYCICGLPDYREDHAACSIMMGLSMVEAISYVREKTQTGVDM 399

  Fly   420 RIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEK 484
            |:|||||.||.||:|..:||||:||.||.:||::|:.|..||||:||.|...|..|:..|:|...
Zfish   400 RVGVHSGTVLGGVLGQKRWQFDVWSTDVTVANKMESGGIPGRVHISQSTKDCLHDEFELEEGNGG 464

  Fly   485 AREDPVLQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTL----HQYNQVRN 545
            .|.|.:|:| ||.|:|:...:                   |.:|.|.:.|.|:    .....|:|
Zfish   465 ERCDYLLEK-GIDTYLVVMAK-------------------ETAKTNGVGNGTVINTSGSSTSVKN 509

  Fly   546 QAKLEMCRELDKMPIGRIQLTKVFRR----------STRLTQDEIEEETFRRNISSCCLFFRIRN 600
            .|        ::.....:||..:...          |..|.:.|.||....:..|:..|.|...:
Zfish   510 TA--------EESETQHLQLPSITEEGMEEEHLNLLSKTLLEREAEEILEEKKTSALSLRFEDPD 566

  Fly   601 WEFQYI--KEPDVMLKYSIALAWVIYMGLLTI----QLLSKDARYHYWYIDGTTIILLTMLLIVS 659
            .|.:|.  ||....:.:|...|.:|:...:.|    ||:   ..|....|....:::||:..:.:
Zfish   567 LESRYSAEKERQTGVAFSCCCAVLIFTSAMEILIDPQLI---VNYVTLAIGELLLLILTLCSLAA 628

  Fly   660 WYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGCSSD 724
            .:.:::            :.||..|    |..:.|....|.......||......:..::.|
Zfish   629 VFPRVF------------SRRLVSF----SQWIDRTRWARNTWAMAAIFVLTMAEVADMLSC--- 674

  Fly   725 EDYADLDPTYDERVQCFHPWILTNCMT------------------------LVIGMSFLFTRIPF 765
                 :.|          |.:|.|..:                        |.:..:.:..::..
Zfish   675 -----VQP----------PLLLLNSSSGVTLESLGNGGCAENPKHYGYISVLSLVATVMLVQLSH 724

  Fly   766 IIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNF----NAKYS--------HILLMIITFGIF 818
            ::|.....|:.|....:.:..:.:||     ...:|    :.:||        .::::|:..|.:
Zfish   725 VVKLALMLLVTIATGAVNIHSWMYIY-----DIYDFIRYLDYRYSVVPTRYLLTVMIIIMMLGFY 784

  Fly   819 HL---MERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYL-SNQLQNELY 879
            :.   :|||:..:    :.||.::..::|.........:.|:||:||.|||..:| |.:...|||
Zfish   785 YFARHVERQSRKL----FLWKIEVTDQKEKVYEMRTYNEALVTNMLPEHVAKHFLGSKKRDEELY 845

  Fly   880 YEEYDNVAVMFASIKNFD----TDKIG------LRVLNEIICDFDDVLNKYSQSLRVEKIKVANW 934
            .:.||.:.||||||.||.    .:.|.      ||:|||||.|||.:|:: ::...:.|||....
Zfish   846 SQSYDEIGVMFASIPNFSDFYTEESINNGGLECLRILNEIISDFDSLLDR-TEFRHITKIKTIGS 909

  Fly   935 TYMAACGLDVSRSEQVNA-PQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLD 998
            |||||.|  |:.....|. ...|..:.||
Zfish   910 TYMAASG--VTPESNTNGYADRKIEDQSL------------------------------------ 936

  Fly   999 LERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGML 1063
            |:|.|:..:                       :|:|||.:...:...|.:        |.:..||
Zfish   937 LDRWQHFAD-----------------------LADFALAMKVMLGNLNKQ--------SFNNFML 970

  Fly  1064 RIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGM 1128
            |||::.|..:|||:|..|||:|||||.||:||||:||||.|.|||.|:....|:|:..:...||.
Zfish   971 RIGLNKGSVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYNILKEYGFRFVRRGP 1035

  Fly  1129 TFVKGRGNIPTYII-GID----SEYQFLPHR 1154
            .:|||:|.:.|:.: |.|    :....|||:
Zfish  1036 IYVKGKGELLTFFMKGKDPVEKTNGMTLPHQ 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	67/253 (26%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	88/181 (49%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	89/274 (32%)
adcy3b	XP_068071803.1	AcyC	95..460	CDD:441717	139/393 (35%)
		Guanylate_cyc	298..460	CDD:425528	78/161 (48%)
		AcyC	627..1048	CDD:441717	130/533 (24%)
		Guanylate_cyc	844..1051	CDD:425528	89/276 (32%)