Protein Alignment ACXD and adcy2a

DIOPT Version :9

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_692173.5
• Gene: adcy2a / 563724
• ZFINID: ZDB-GENE-061109-1
• Length: 1155
• Species: Danio rerio
• Alignment Length: 1253
• Identity: 349/1253 - (27%)
• Similarity: 546/1253 - (43%)
• Gaps: 312/1253 - (24%)

  Fly    37 WSYLVRKCRNLELEDS-------------------------YDLYMRRLRVGYLSLFIFIHV--- 73
            |...:|| |:..||.|                         ||.|.|..:...|.:|:.:.|
Zfish    53 WREAIRK-RSYLLERSSKTGGNVKGGGGGVRGRRQRSPDWLYDSYHRMSQQHPLIVFLLLIVMGA 116

  Fly    74 --AVTVI----------HTLLLLTTPEIKYVYVDMVAYMC-----------SGLVIW---VVLGV 112
              |:..:          |...::|.|....:::.:...:|           ..||||   |.:|.
Zfish   117 CLALLAVFFASGLDIEDHVAFVITVPTALAIFLTIFVLVCIESVFKKLLRVFSLVIWGCLVAMGY 181

  Fly   113 NFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPYL 177
            .|                         |..|          .|:.| :|..:.:...:|  |.|.
Zfish   182 LF-------------------------MFFG----------GIICP-WDQVSFFLFIIF--VVYT 208

  Fly   178 LQPFVLGSAVTFCYIINYSFVITAKDDNQMHS----------------ILNEAIYLSCVNLLGIF 226
            :.||.:..|:       .:.|:||.....:.|                ||...|...|.|:.|.:
Zfish   209 MLPFSMRDAI-------IASVLTASSHTVVLSVCLSSTVSHVEPLVWQILANVIIFICGNVAGAY 266

  Fly   227 FRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQ 291
            .:.:.::||:.|:.|....::..:.|.:.:.|:..||||:|||.||..::.::..|::..|....
Zfish   267 HKHLMELALKQTYQDTCNCIKSPIKLEFEKRQQERLLLSLLPAHIARVMKAEIIQRLQGPKFGQV 331

  Fly   292 QQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLF 356
            :.:.                  :...|:::.|.:|::||||:|.:|.|.:.....:||..|::||
Zfish   332 ENTN------------------NFHNLYVQRHTNVSILYADIVGFTRLASDCSPGELVHMLNELF 378

  Fly   357 VRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRI 421
            .:||..::|...:|||.||||||||:||.....:|||.||.:||.|.:.|:.||:...:.|.||:
Zfish   379 GKFDQIAKENECMRIKILGDCYYCVSGLPESLPNHAKNCVKMGLDMCEAIKKVRDATGVEISMRV 443

  Fly   422 GVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAR 486
            |||||:||.||||..|||:|:||.||.:||.:||.|..||||::.:||..|:|.|..|||..:.|
Zfish   444 GVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITSETLEHLNGAYKVEDGHGQER 508

  Fly   487 EDPVLQKHGIRTFLI----KSLRAPMH--DPRR-----RMRE--RQVKKLSE--ASK--ANFMHN 534
             ||.|::||:.|:|:    ...::|.|  .||.     :||.  |..:.|..  |:|  ||..|.
Zfish   509 -DPYLKEHGVITYLVINPKVERKSPQHYYRPRHTIDGAKMRASVRMTRYLESWGAAKPFANLHHR 572

  Fly   535 STLHQYNQVRNQAKLEMCRELDKMPIGRIQLTKVFRRSTRLT------QDEIEEETFR------- 586
            .::...|...|.|         .:|||:....   |||.|..      ::|:.|...|
Zfish   573 DSMTNENGKINTA---------DVPIGQYHFQ---RRSERTKSQKKRFEEELNERMIRTFDGINS 625

  Fly   587 -------RNISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLLSKDARYHYWYI 644
                   .:|....|||..:..|.:|........||.|..|.:|:..:..:|:|...........
Zfish   626 QKQWLKSEDIQRISLFFHNKALEKEYRATTLPAFKYYITCACLIFFCIFIVQILVLPKTAILGVS 690

  Fly   645 DGTTIILLTMLLIV---------------SWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQR 694
            .|.:.::|:::|:|               ||   :||:..|....|.|..|:       :..|..
Zfish   691 FGMSFLILSVILLVCFIGHFLQCKKTASASW---VWILRSSGIIASKPWPRI-------TLTMAT 745

  Fly   695 NVVIRVVMYFLIIFSYCAVAIMQVVGCSSDEDYADLD----PTYDERVQCFHPWILTNCMTLVIG 755
            ..:|.::..|.:.|....:.:|:.|..:|:|.....|    |..|:.. .:.|:.:.:|:..:|.
Zfish   746 TALILIMAVFNMFFIEDNLTLMETVYNTSNETLLQPDGQPIPYLDKNT-FYLPYFIYSCILGLIS 809

  Fly   756 MSFLFTRIPFIIKSCFSALIMIGYAVLV-------VSEFN-FIYANS--PSTNVNFNAKYSHILL 810
            .| :|.||.:.:|.......::.|:|::       :.|:: |:|...  ....|..:.|....:.
Zfish   810 CS-VFLRINYELKMLIMLTAVVLYSVIILQTHASLLDEYSKFLYKTEVIERPGVLKDLKTMGSVS 873

  Fly   811 MIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQ 875
            :.|.|....::.||.|:..::|:.||.:..|:.|:.....:..:|||.|:||.|||:.:|:...:
Zfish   874 LFIFFITLLVLARQNEYYCRLDFLWKNKFKKECEEIETMENLNRVLLENVLPAHVAEHFLARNWK 938

  Fly   876 NE-LYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKYSQSLRVEKI 929
            || ||::.||.|.||||||.:|       |.:|.|   ||:|||||.|||::|:|...| .||||
Zfish   939 NEDLYHQSYDLVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDELLSKPKFS-GVEKI 1002

  Fly   930 KVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIA 994
            |....|||||.||:.
Zfish  1003 KTIGSTYMAATGLNA-------------------------------------------------- 1017

  Fly   995 LDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTD 1059
                           |.||..:..|:....:  :..|.|||..|:..:...|..:.       .|
Zfish  1018 ---------------TPGPEYTQEHDRQYMH--IGTMVEFAFALVGKLDVINKHSF-------ND 1058

  Fly  1060 YGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCN 1124
            : .||:||:||...|||:|..||.||||||.||:|||||||||.|:|||||.|:..|:.....|:
Zfish  1059 F-KLRVGINHGPVKAGVIGAQKPQYDIWGNTVNVASRMDSTGVLGKIQVTEETSCILQTLGYTCS 1122

  Fly  1125 YRGMTFVKGRGNIPTYII 1142
            .||:..|||:|.:.||.:
Zfish  1123 CRGIINVKGKGELKTYFV 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	62/311 (20%)
		CYCc	254..476	CDD:214485	89/221 (40%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	88/185 (48%)
		CYCc	856..1117	CDD:214485	98/271 (36%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	97/273 (36%)
adcy2a	XP_692173.5	AC_N	<92..319	CDD:292831	55/271 (20%)
		CYCc	295..498	CDD:214485	89/220 (40%)
		Guanylate_cyc	340..524	CDD:278633	89/184 (48%)
		DUF1053	554..658	CDD:283888	25/115 (22%)
		CYCc	912..1120	CDD:214485	100/283 (35%)
		Guanylate_cyc	942..1141	CDD:278633	97/275 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880