Protein Alignment ACXD and adcy5

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_068079526.2
• Gene: adcy5 / 562619
• ZFINID: ZDB-GENE-081104-470
• Length: 1191
• Species: Danio rerio
• Alignment Length: 1271
• Identity: 337/1271 - (26%)
• Similarity: 563/1271 - (44%)
• Gaps: 320/1271 - (25%)

  Fly    12 NRSNP-----------ISLA----RTSSQ-AQTVQNEKNWEWS---------YLVRKCRNLELED 51
            |||:|           :.|.    ||.|: .:.:..|.|:..|         :..:|.::.:||.
Zfish    94 NRSSPRYRDGEVRPKSVELGLEDRRTKSKPEEELMPEVNFSMSACCNSVMQIFRSKKFQSEKLER 158

  Fly    52 SYDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSG------------- 103
            .|..|..||....|::.:.:.|.|..:                 |:.:.|:|
Zfish   159 LYQRYFFRLNQSSLTMLMAVLVLVCAV-----------------MLGFHCAGGMCQLTYVLVFTA 206

  Fly   104 --LVIWVVLGVNFRSELVSKHGWVVYATSWLAVC-VMVLMDIGLNVYHATSHNDILNPIYDAYTL 165
              ::|..::.|..|:.....|.|:        || :::|:.:.:.|....    .:.|...:..:
Zfish   207 AIVLILTLMVVCNRNGFHQDHMWI--------VCYLLILLVLAVQVVGVL----FVKPRSASEGI 259

  Fly   166 YAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQM-----HSILNEAIYLSCVNLLGI 225
            :....|:.|.|.|.|..:.:||....|::...|:.:...|.|     ..:::..:..||.|::|:
Zfish   260 WWTVFFIHVIYTLLPVRMRAAVITGIILSAIHVLISWRLNDMDVFLWKQLVSNVLIFSCSNIVGV 324

  Fly   226 FFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQH 290
            ......:.:.|..|.:.|:.::..|..:....|:..||||:||..:|..::.|:     .:||:.
Zfish   325 CTHYPAEGSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVALEMKADI-----NAKQED 384

  Fly   291 QQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDL 355
            ....::                      :|:.|::|::|:||:..:|.|.:....::||..|::|
Zfish   385 MMFHKI----------------------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNEL 427

  Fly   356 FVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMR 420
            |.|||..:.|.:.||||.||||||||:||....||||.|||::|:.||:.|..|||...:|::||
Zfish   428 FARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMR 492

  Fly   421 IGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKA 485
            :|:|||.|..||:|..|||||:||.||.:||.:||.|..||:|:::.||:.|:|:|..|.|:...
Zfish   493 VGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYDVEPGSGGE 557

  Fly   486 REDPVLQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTLHQ-----YNQVR- 544
            | :..|:||.|.|:||...     ..:|:..:..:.|::.....:..|||| |.     ||.:.
Zfish   558 R-NVYLKKHNIETYLIVGC-----SQKRKEEKAMIAKMNRQRTNSVTHNST-HWTDRPFYNHLNA 615

  Fly   545 NQAKLEMCRELDKMPIGRIQLTKVFRRSTR--LTQDEIEEETFR----RNISSCCLFFRIRNWEF 603
            |....||.|...:.|..:   ..:||.:..  ..:||::|...|    |:|.      |:|:
Zfish   616 NSVSKEMKRMGFEDPKDK---HFIFRNTQENLNPEDEVDEFLGRAIDARSID------RLRS--- 668

  Fly   604 QYIK-------EPDVMLKYS----------IALAWVIYMGLLTIQLLSKDARYHYWYIDGTTIIL 651
            :::|       |||:..|||          :..|.::::.:..||::...   |...:.|..::.
Zfish   669 EHVKKFLLTFREPDLEKKYSKQVDSSFGAYVVCASLVFLFICFIQIIIVP---HSGLMVGFYVLC 730

  Fly   652 LTMLLIVSWYKKLW---------IMYMSDADVSSP-NGRLSGFLFRMSDEMQRNVVIRVVMYFLI 706
            |.:|::|.:...::         :..:|...|.|. |..|.|             |..:|:.|:.
Zfish   731 LVVLMVVMFISAIYSCFGFFPIPLQTLSKRIVQSRLNSTLVG-------------VFTIVLVFIS 782

  Fly   707 IFSYCAVAIMQVVGCSSDE---------------------DYADLDPTY--------DERVQCFH 742
            .|       :.:..||:|:                     .::.|:.|.        .....|..
Zfish   783 AF-------INIFTCSTDDLKTCLGQEFNISPSNVNACHAHFSSLNYTLWSQNRLCNSSSPTCNF 840

  Fly   743 PWILTNCMTLVIGMSFLFTRIPFIIKSCFSALIMIGYAVLV----VSEFN----FIYANSPSTN- 798
            |...::|:.|.:....:|.::..|.|......|.|.|.:::    ||.|:    .:.||:.:.|
Zfish   841 PEYFSSCVLLSLLACSVFLQVSSIGKLFLMLFIEILYVLIMEVPEVSLFDNVDLLVMANALAPNN 905

  Fly   799 ----VNFNAKYSHILLMIITFGI--FHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLL 857
                |:.......:..::||..:  .:|..:|.|..|::|:.||.|..:::|:........:.||
Zfish   906 GTCIVDTRVPLKIVTPVVITVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLL 970

  Fly   858 TNILPTHVADFYLSNQLQN-ELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIIC 911
            .||||..||..:|:.:.:| ||||:..:.||||||||.||       :.:..|   ||:|||||.
Zfish   971 HNILPKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIA 1035

  Fly   912 DFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARS 976
            |||::::: .|..::||||....|||||.||:                        .|.||.|..
Zfish  1036 DFDEIISE-DQFRQLEKIKTIGSTYMAASGLN------------------------DSTYDKAGR 1075

  Fly   977 SNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRT 1041
            |:                                                 :|.:|::|:.||..
Zfish  1076 SH-------------------------------------------------IRALADYAMRLMDQ 1091

  Fly  1042 MRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQI 1106
            |:..|        |.|.:...::||::.|..:|||:|..||.||||||.||:||||||||||.:|
Zfish  1092 MKYIN--------EHSFNNFKMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPERI 1148

  Fly  1107 QVTENTALKLREFNIQCNYRGMTFVKGRGNIPTYII 1142
            |||.:....|..:|....|||:..|||:|.:.||.:
Zfish  1149 QVTTDLYQVLSSYNYTLEYRGVVKVKGKGEMMTYFL 1184

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	51/262 (19%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	87/181 (48%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	92/273 (34%)
adcy5	XP_068079526.2	None