DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and ADCY10

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_060887.2	Gene:	ADCY10 / 55811	HGNCID:	21285	Length:	1610	Species:	Homo sapiens

Alignment Length:	899	Identity:	167/899 - (18%)
Similarity:	304/899 - (33%)	Gaps:	296/899 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 TTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRS 301
            |||:   .|        |...:.::||      ::|..|:.|.:  :|.|.|::..:|   :.:.
Human   234 TTFM---HY--------YPSGEHKNLL------RLACTLKPDPE--LEMSLQKYVMES---ILKQ 276

  Fly   302 ADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVV----------------NYTHLTTTLDVKKLVE 350
            .|::.|:.         ::.....||:::.:::                .|.|:|:.|   |:.:
Human   277 IDNKQLQG---------YLSELRPVTIVFVNLMFEDQDKAEEIGPAIQDAYMHITSVL---KIFQ 329

  Fly   351 ALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNA----DHAKCCVDLGLRMIKDIRDVRE 411
            ...:....||             .|..:.||.|......    .||..|.       .||.|...
Human   330 GQINKVFMFD-------------KGCSFLCVFGFPGEKVPDELTHALECA-------MDIFDFCS 374

  Fly   412 KRHLNIDMRIGVHSGDVLSGVIG-AAKWQFDIWSKDVDIANRLEA--TGATGRVHVSQKTLSLLD 473
            :.|....:.|||.||.|..|::| ..:.::.:..:.|::|.|:..  .|......|:....:|
Human   375 QVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNLAARMMMYYPGIVTCDSVTYNGSNL-- 437

  Fly   474 GEYFFEDGTEK-----AREDPVLQKHGIRTFLIKSLRAPMHDPRRR-----MRERQVKKLSEASK 528
            ..|||::..:|     |...|:.|..| ||..:....|.:...|:.     .|.:::.......|
Human   438 PAYFFKELPKKVMKGVADSGPLYQYWG-RTEKVMFGMACLICNRKEDYPLLGRNKEINYFMYTMK 501

  Fly   529 ANFMHNST-LHQYNQVRNQAKLEMCRELDKMPIGR------IQLTKVFRRSTRLTQDEIEEETFR 586
            ...:.||: :..|..:....|.::..:::.:..|:      |.|.|:....|..|     .:.|.
Human   502 KFLISNSSQVLMYEGLPGYGKSQILMKIEYLAQGKNHRIIAISLNKISFHQTFYT-----IQMFM 561

  Fly   587 RNI---SSC-----------------------CLFFRIRNWEFQYIKEPDVM--LKYSIALAWVI 623
            .|:   .:|                       ||...|.:.:|...:|...|  ||....|. ::
Human   562 ANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLNDIFHVQFPISREISRMSTLKKQKQLE-IL 625

  Fly   624 YMGLLTIQLLSKDARYHY-----WYIDGTT-------IILLTMLLIVSW--------------YK 662
            :|.:|  :|:.|:.|..:     .::|.|:       |..|.:.:|:|.              .|
Human   626 FMKIL--KLIVKEERIIFIIDEAQFVDSTSWRFMEKLIRTLPIFIIMSLCPFVNIPCAAARAVIK 688

  Fly   663 KLWIMYM---------------SDADVSSPNGRLSGFLFRMS-------DEMQRNVVIRVVMYF- 704
            .....|:               .|.:||..:..|..:|...|       :|:.:|:....|:.|
Human   689 NRNTTYIVIGAVQPNDISNKICLDLNVSCISKELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQ 753

  Fly   705 --------------LIIFSYCAVAIMQVVGCSSDEDYADL-------------DPTYDERVQCF- 741
                          |..:|......:.:|...||::..::             .||..:.:...
Human   754 QTESEEKTNRTWNNLFKYSIKLTEKLNMVTLHSDKESEEVCHLTSGVRLKNLSPPTSLKEISLIQ 818

  Fly   742 -------HPWILTNCMTLVIGMSFLFTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYA------- 792
                   |. :|..| ..:||::|. |.:.|.|..|::..:||.....:| |.|..|.
Human   819 LDSMRLSHQ-MLVRC-AAIIGLTFT-TELLFEILPCWNMKMMIKTLATLV-ESNIFYCFRNGKEL 879

  Fly   793 ------NSPSTNVNFNAKYSHILLMIITFGIFH-----LMERQTEFI------------AKVDYN 834
                  |.||..|::.:     |.:..:.|:.|     |.|.:.|.|            .|..|.
Human   880 QKALKQNDPSFEVHYRS-----LSLKPSEGMDHGEEEQLRELENEVIECHRIRFCNPMMQKTAYE 939

  Fly   835 -WKRQLIKKQEDAL-------ITND------------------TIKVLLTNILPTHVADFYLSNQ 873
             |    :|.|..|:       :..|                  |:.:.|..:....:....:|:.
Human   940 LW----LKDQRKAMHLKCARFLEEDAHRCDHCRGRDFIPYHHFTVNIRLNALDMDAIKKMAMSHG 1000

  Fly   874 LQNE----LYYEEYDNVAVMFASIKNFDTDKIGLRVLNEIICDFDDVLNKYSQS 923
            .:.|    |...|....:..|.  :|...::|..::||    .||.||.|...|
Human  1001 FKTEEKLILSNSEIPETSAFFP--ENRSPEEIREKILN----FFDHVLTKMKTS 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	10/46 (22%)
		CYCc	254..476	CDD:214485	46/244 (19%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	44/209 (21%)
		CYCc	856..1117	CDD:214485	16/72 (22%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	13/46 (28%)
ADCY10	NP_060887.2	CHD	40..214	CDD:143636
		AcyC	<42..197	CDD:225025
		CHD	292..461	CDD:143636	40/193 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900