Protein Alignment ACXD and adcy2b

DIOPT Version :9

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_005170095.1
• Gene: adcy2b / 557902
• ZFINID: ZDB-GENE-060503-69
• Length: 1142
• Species: Danio rerio
• Alignment Length: 1214
• Identity: 333/1214 - (27%)
• Similarity: 533/1214 - (43%)
• Gaps: 291/1214 - (23%)

  Fly    53 YDLYMRRLRVGYLSLFIFIHV-----AVTVI----------HTLLLLTTPEIKYVYVDMVAYMC- 101
            |:.|.|..:...|.:|:.:.|     |:..:          |...::|.|....:::.:...:|
Zfish    81 YESYYRMSQQHPLIVFLLLIVMGACLALLAVFFASGLDMEEHMAFIMTVPTTLAIFLAIFILVCI 145

  Fly   102 ----------SGLVIW---VVLGVNFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHN 153
                      ..|:||   |.:|..|..     .|.::  ..|..|...:.:
Zfish   146 ESVFKKLLRLFSLLIWGCLVAMGYLFMF-----FGGII--CPWDQVSFFLFI------------- 190

  Fly   154 DILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAVT-FCYIINYSFVITAKDDNQ---MHSILNEA 214
                 ::..||:        :|:.::..|:.|.:| ..:.:..|..::...|:.   :..||...
Zfish   191 -----VFVVYTM--------LPFSMRDAVIASVLTSSSHTLVLSICLSNTSDHMEALVWQILANI 242

  Fly   215 IYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDV 279
            |...|.|:.|.:.:.:.|:||:.|:.|....::..:.|.:.:.|:..||||:|||.||..::.::
Zfish   243 IIFICGNVAGAYHKHLMDLALKQTYHDTCNCIKSPIKLEFEKHQQERLLLSLLPAHIARVMKAEI 307

  Fly   280 KNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLD 344
               |:|.|..:..|::               ...:...|:::.|.:|::||||:|.:|.|.:...
Zfish   308 ---IQRLKGPNFSQAE---------------NTNNFHNLYVQRHTNVSILYADIVGFTRLASDCS 354

  Fly   345 VKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDV 409
            ..:||..|::||.:||..:::.:.:|||.||||||||:||.:|..||||.||.:||.|.:.|..|
Zfish   355 PGELVYMLNELFGKFDQIAKDNDCMRIKILGDCYYCVSGLPDPLLDHAKNCVKMGLDMCEAIEKV 419

  Fly   410 REKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDG 474
            ||...::|:||:|||||:||.||||..|||:|:||.||.:||.:||.|..||||:|..||..|:|
Zfish   420 REATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNG 484

  Fly   475 EYFFEDGTEKAREDPVLQKHGIRTFLI-------------KSLRAPMHDPRRRMRERQVKKLSEA 526
            .|..|.|..::| |..|::|||.|:|:             .::|..|:..:.|...|..:.|...
Zfish   485 AYKVEQGNGQSR-DSYLKEHGIVTYLVINPKAEKRSPLLLSAIRPTMYGAKMRASVRMTQYLESW 548

  Fly   527 SKANFMHNSTLHQYNQVRNQAKLEMCRELDKMPIGRI---QLTKVFRRSTRLTQDEIEEETFR-- 586
            ..|....|  ||..:.:.|:..:...|:   :|:|:.   |.::..:...:..::|:.|...|
Zfish   549 GAAKPFAN--LHHRDSMTNENGMINTRD---VPLGQYNCQQRSERTKSQKKRFEEELNERIIRTI 608

  Fly   587 ------------RNISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLLSKDARY 639
                        .:|....|||..:..|.:|........||.:..|.:|:..:..:|:|......
Zfish   609 DGINSQKQWLKSEDIQRISLFFHNKALEKEYRATTLPAFKYYVTCACLIFFCIFIVQVLVLPKTT 673

  Fly   640 HYWYIDGTTIILLTMLL-------IVSWYK------------------KLWIMYMSDADVSSPNG 679
            ......|...:||.::|       |:.|.|                  |.||
Zfish   674 VLEVSFGMAFLLLALILCICFAGHILQWGKAASCTMPRLPSSSKVITNKPWI------------- 725

  Fly   680 RLSGFLFRMSDEMQRNVVIRVV----MYFLIIFSYCAVAIMQVVGCSSDEDYADLDPTYDERVQC 740
                   |::..|....:|.|:    |:||......|...:.:...|.|..|..:  |.....:.
Zfish   726 -------RLALTMATTALILVMAVFNMFFLGEDRMVASTSLNISNSSMDGPYGQI--TNSSNNKF 781

  Fly   741 FHPWILTNCMTLVIGMSFLFTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNFNAKY 805
            :.|:.:.:|:..:|..| :|.||.:.:|    .:||:|    .|..:|.|..   .|:.:....|
Zfish   782 YLPYFIYSCILGLISCS-VFLRINYELK----MIIMLG----AVVAYNIIIL---QTHASILDDY 834

  Fly   806 SHILL---------------------MIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALIT 849
            |..|.                     :.|.|....::.||.|:..::|:.|:.:..|:.|:....
Zfish   835 SMALYKTQQPDRPGVLKDLKTMGSISLFIFFVTLLVLARQNEYYCRLDFLWRNKFKKECEEIETM 899

  Fly   850 NDTIKVLLTNILPTHVADFYLSNQLQNE-LYYEEYDNVAVMFASIKNF-------DTDKIG---L 903
            .:..:|||.|:||.|||:.:|....:|| ||::.||.|.||||||.:|       |.:|.|   |
Zfish   900 ENLNRVLLENVLPAHVAEHFLGRNWKNEDLYHQSYDTVCVMFASIPDFKEFYTESDVNKEGLECL 964

  Fly   904 RVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRR 968
            |:|||||.|||::|:|...| .|||||....|||||.||:|:..
Zfish   965 RLLNEIIADFDELLSKPKFS-GVEKIKTIGSTYMAATGLNVTPG--------------------- 1007

  Fly   969 SRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAE 1033
                                          ||..||...        ...|.|:        |.|
Zfish  1008 ------------------------------LEYAQYHDR--------QYMHIGT--------MVE 1026

  Fly  1034 FALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMD 1098
            ||..|:..:...|..:.       .|:.| |:||:||..:|||:|..||.||||||.||:||||:
Zfish  1027 FAFALVGKLDVINKHSF-------NDFRM-RVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRME 1083

  Fly  1099 STGVPGQIQVTENTALKLREFNIQCNYRGMTFVKGRGNIPTYII 1142
            ||||.|:|||||.|...|:.....|:.||:..|||:|::.|:.:
Zfish  1084 STGVLGKIQVTEETNWILQTLGYMCSCRGIINVKGKGDLRTFFV 1127

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	50/263 (19%)
		CYCc	254..476	CDD:214485	94/221 (43%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	90/194 (46%)
		CYCc	856..1117	CDD:214485	100/271 (37%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	98/273 (36%)
adcy2b	XP_005170095.1	AC_N	<80..307	CDD:292831	50/258 (19%)
		CYCc	283..486	CDD:214485	94/220 (43%)
		Guanylate_cyc	328..512	CDD:278633	91/184 (49%)
		DUF1053	542..646	CDD:283888	19/108 (18%)
		CYCc	899..1106	CDD:214485	102/282 (36%)
		Guanylate_cyc	929..1128	CDD:278633	98/275 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880