DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and gucy1b2

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	611	Identity:	138/611 - (22%)
Similarity:	246/611 - (40%)	Gaps:	177/611 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 TSSQAQTVQNEKNWEWSYLVRKCRNLELEDSYDLYMRRLRVGYLSLFIFIHVAV--TVIHTLLLL 84
            |..:|||.||....|         .||::...:..|||::..|.:|.:......  .::.::::|
Zfish   190 TKRKAQTRQNNSEEE---------ILEVKKDKEETMRRMKARYANLQLCPRKRSPWELVRSIVML 245

  Fly    85 --------TTPEI-KYVYVDMVAYMCSGLVIWVVLGVNFRSELVSKHGWVVYATSWLAVCVMVLM 140
                    .||.. |.::::..|: |:.....:|    |.|:||.||..|.     :...|..|.
Zfish   246 GQGNLRQSFTPSYPKTLWIEEQAF-CNAFPFHIV----FDSDLVVKHTGVN-----IQKFVPGLQ 300

  Fly   141 DIG--LNVYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAK- 202
            ..|  |:.|....|.:::      :.:.:|..|                     ||..||:..:
Zfish   301 TAGIRLDEYFTIVHPEVI------FNIQSIKKF---------------------INSQFVLKTRR 338

  Fly   203 ------DDNQ-----------MHSILNEAIYLSCVNLLGIFFRLMRDIALRTTFL-DRRQYVEEN 249
                  ..||           |.| ||..|||....|     |.::::..|...| |..|:
Zfish   339 EMLPEVQQNQPTLKLRGQMMWMES-LNCMIYLCSPKL-----RSLQELEERGLHLADIAQH---- 393

  Fly   250 LLLRYARDQERSLLLSILPAQIADRLQE-DVKNRIERSKQQHQ---QQSQVDLRRSAD------- 303
                   |..|.|:|  |..|   ||.| ::.|::||.|::.:   :..:::.::|..
Zfish   394 -------DTTRDLIL--LNQQ---RLAEIELSNQLERKKEELRILSRNLEIEKQKSEKLLYAMLP 446

  Fly   304 ---SQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEE 365
               :..||..::.:.|...:     .|:|::|||.:|::....:..::|..|:.::.|||..:..
Zfish   447 THVANQLKEGKRVEAGEFKV-----CTILFSDVVTFTNICAACEPIQIVNMLNAMYSRFDRLTSI 506

  Fly   366 YNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREK-RHLNIDMRIGVHSGDVL 429
            :||.:::.:||.|..|.|:..|...||:...:..|.|....|:|... ....|.:|:|:|:|.||
Zfish   507 HNVYKVETIGDAYMVVGGVPVPTNTHAERVANFALGMRIAAREVTNPITGQPIQIRVGLHTGPVL 571

  Fly   430 SGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKH 494
            :||:|....::.::...|:.|:|:|:.|....:|||..|.|::..:..||  ..:..|..|..|.
Zfish   572 AGVVGEKMPRYCLFGDTVNTASRMESHGVPDHIHVSPFTFSVIKDKGIFE--MAERGEIEVKGKG 634

  Fly   495 GIRT-FLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTLHQYNQVRNQAKLEMCRELDKM 558
            .:|| ||:|:|         :..:.|:..|.:.                       |||
Zfish   635 LMRTYFLLKNL---------QKSDEQIMGLVDG-----------------------EMC------ 661

  Fly   559 PIGRIQLTKVFRRSTRLTQDEIEEET 584
                            :.|:::||||
Zfish   662 ----------------VYQEDLEEET 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	58/274 (21%)
		CYCc	254..476	CDD:214485	62/236 (26%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	54/183 (30%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002
		CAF-1_p150	<166..277	CDD:288454	20/96 (21%)
		HNOBA	269..453	CDD:285003	50/242 (21%)
		CYCc	432..618	CDD:214485	49/190 (26%)
		Guanylate_cyc	459..642	CDD:278633	54/189 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900