DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and adcy1a

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001161821.1	Gene:	adcy1a / 557026	ZFINID:	ZDB-GENE-070705-302	Length:	1114	Species:	Danio rerio

Alignment Length:	1187	Identity:	324/1187 - (27%)
Similarity:	519/1187 - (43%)	Gaps:	262/1187 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 CRNLE-LEDSYDLYMRR-----------LRVGYLSLFIFI------------HVAVTVIHTLLLL 84
            |:.|| |...|:|.:.:           |....|:|...:            |....||.|.|.:
Zfish    34 CKELETLFQKYNLKLEQTATLKALAILILAASALALVELLSAGSRFTVSKGSHPVHCVIFTSLFI 98

  Fly    85 TTPEIKYVYVDMVAYMCSGLVIWVVLGVNFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHA 149
            .| .:||:.|..:..:               :.|.     ::::.::..:|....:.:|    |.
Zfish    99 VT-NVKYLQVTQLQQI---------------ARLA-----LLFSFTFALLCCPFPLALG----HG 138

  Fly   150 T--SHN---DILNPIYDAYTL----YAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDN 205
            |  :|.   ....|....:.|    :..|..:||..|| ..:.|..|...:.|..:..:||:...
Zfish   139 TQGTHGPDAPSTTPEQGVWQLMLVTFVAYSLLPVRTLL-AVLFGVLVAASHFIVTATSVTARRPR 202

  Fly   206 QMHSILNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQ 270
            ....::..|:.|..|||.|:|.|:..:.|.|..||..|..:::.|.|....:::..||:|:||..
Zfish   203 VWTPLVANAVLLVGVNLSGVFVRVRTERAQRKAFLQARNCIQQRLQLEDENEKQERLLMSLLPRN 267

  Fly   271 IADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVN 335
            :|..::||.....||...:                            ::|:.|::|::|:||:|.
Zfish   268 VAMEMKEDFLKPPERIFHK----------------------------IYIQRHDNVSILFADIVG 304

  Fly   336 YTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGL 400
            :|.|.:....::||:.|::||.:||..:.|.:..|||.||||||||:||..|.||||.|||::||
Zfish   305 FTSLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKADHAHCCVEMGL 369

  Fly   401 RMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVS 465
            .||..|..|.|...::::||:|:|:|.||.||:|..|||:|:||.||.:||.:||.|..|:||::
Zfish   370 DMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLPGKVHIT 434

  Fly   466 QKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKAN 530
            :.||..|:|:|..|.|....|. ..|.||.|.||.|    .|.|  ||::....:  ||:...|.
Zfish   435 KATLECLNGDYEVEPGFGHERH-AFLSKHAIETFFI----VPSH--RRKIFPGLI--LSDIKPAK 490

  Fly   531 FMHNST----LHQYNQVRNQAKLEM-------CRELDK----------------MPIGRIQL--- 565
            .|...|    |.|....|...|.|:       |.:.||                ...|.:|.
Zfish   491 RMEFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRTSFSAGMVQNSPG 555

  Fly   566 TKVFRRSTRLTQDEIEEETFRRNISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTI 630
            |:|.|...||.:.. :.|:...:::...|.:|.|..|.:|::..|.....::.::.|:......:
Zfish   556 TRVNRYIGRLIEAR-QTESEMADLNYITLTYRSREREQRYLQVYDDAFISAVVISLVLTSFFAVV 619

  Fly   631 QLLSKDARYHYWYIDGTTIILLTMLLIVSWYKKLWIMYMSDADVS-SPN-------GRLSGFLFR 687
                      |:.|....::::.:|::...:....:||:....|. ||:       ..|.|||..
Zfish   620 ----------YFLIIPQGLLVVILLVLCLCFHMASVMYLHVTHVQCSPDCLTLQIRTVLCGFLVL 674

  Fly   688 MSDEMQRNVVIRVVMYFLI-IFSYCAVAIMQVVGCSSDEDYADLDPTYDERVQCFHPWILTNCMT 751
            :...:.:..|:..|.:.|. ..|...|.::.|.|..           ...||..:.|::..:|:.
Zfish   675 LMYSVTQGCVVTCVPWSLEGNSSISMVTVVTVNGTG-----------VGYRVCKYTPYVFLSCVM 728

  Fly   752 LVIGMSFLFTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNFNAKYSHILLMIITFG 816
            ..:.:: |:.|:..:.|.....|:.|.:.|::.:..   |..:..........|..:|.|::..|
Zfish   729 ASLSVA-LYLRVSSLPKILLLLLLNILHTVVMETSG---YRKAVGGGFFHTHGYDPVLAMLLFSG 789

  Fly   817 IFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVAD-FYLSNQLQNELYY 880
            ...|..||.:...::||.|..|..::::|........|.:|.|:||.|||. |.|||....:|||
Zfish   790 ALVLHCRQLDLKLRLDYLWATQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLLSNPRNMDLYY 854

  Fly   881 EEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNK--YSQSLRVEKIKVAN 933
            :.|..|.|:||||.||       |.:.:|   ||:|||||.|||.:::|  |..   :||||...
Zfish   855 QSYSQVGVLFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDALMDKECYRD---IEKIKTIG 916

  Fly   934 WTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLD 998
            .|||||.||                                          ||
Zfish   917 STYMAAVGL------------------------------------------VP------------ 927

  Fly   999 LERGQYEGNVITSGPRIS---STHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDY 1060
                       |.|.::.   |.|        :..:|::|:::...:...|       |:...|:
Zfish   928 -----------TEGSKVKKSISAH--------LCTVADYAIEMFDVLDAIN-------YQSYNDF 966

  Fly  1061 GMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNY 1125
             :||:||:.|..:|||:|..:|.||||||.||:|||||||||.|:|||||: ..:|.......|.
Zfish   967 -VLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGKIQVTED-VFRLLSGYYDFNC 1029

  Fly  1126 RGMTFVKGRGNIPTYII 1142
            ||...|||:|.:.||.:
Zfish  1030 RGQVSVKGKGQMLTYFL 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	59/272 (22%)
		CYCc	254..476	CDD:214485	85/221 (38%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	85/181 (47%)
		CYCc	856..1117	CDD:214485	92/276 (33%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	91/278 (33%)
adcy1a	NP_001161821.1	AC_N	<154..285	CDD:292831	36/131 (27%)
		CYCc	251..446	CDD:214485	85/222 (38%)
		Guanylate_cyc	287..469	CDD:278633	85/182 (47%)
		DUF1053	513..601	CDD:283888	18/88 (20%)
		CYCc	819..1029	CDD:214485	94/294 (32%)
		Guanylate_cyc	852..1048	CDD:278633	91/280 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810