DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and npr1b

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_009290669.2	Gene:	npr1b / 555911	ZFINID:	ZDB-GENE-100805-4	Length:	1070	Species:	Danio rerio

Alignment Length:	468	Identity:	105/468 - (22%)
Similarity:	203/468 - (43%)	Gaps:	113/468 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 LVIWVVLGVNF-RSELVSKHGWVVYATSWLAVC------VMVLMDIGLNVYHATSHNDILNPIYD 161
            |:..:|.|:.| .:.::..||.:..:.     |      |:.:.|.||:.....|..:      |
Zfish   649 LISDIVKGMAFLHNSVIVSHGNLKSSN-----CVVDNRFVLKITDYGLSSIRTESDTE------D 702

  Fly   162 AYTLYAIYMFMPVPYL--LQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAIYLSCVNLLG 224
            |::.||..::: .|.|  ::.|..|.              |.|.|.....|:.:.:.|.    .|
Zfish   703 AHSYYARKLWL-APELSRMECFPPGG--------------TQKGDVYSFGIILQEVALR----RG 748

  Fly   225 IFFRLMRDIALRTTFLDR---------------------------RQYVEE----------NLLL 252
            :|: |..|:......:||                           |.:.||          ::||
Zfish   749 VFY-LEGDLLSPKEIVDRVALGEWPYLRPSLNPQAHSEELGQLMQRCWAEEPSDRPEFSHISVLL 812

  Fly   253 RYARDQERSLLLSILPA---QIADRLQEDVKNRIERSKQQHQQQSQVDLRRSAD----------- 303
            |....:.||.:|..|.:   |.|:.|:|.|:.|         .|:.::.:|.|:
Zfish   813 RKQNREHRSNILDNLLSRMEQYANNLEELVEER---------TQAYLEEKRKAEALLYQILPHSV 868

  Fly   304 SQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNV 368
            ::.|||..     |:..|..:.||:.::|:|.:|.|:......::|..|:||:..||...:.::|
Zfish   869 AEQLKRGE-----TVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDV 928

  Fly   369 LRIKFLGDCYYCVAGLANPNAD-HAKCCVDLGLRMIKDIR--DVREKRHLNIDMRIGVHSGDVLS 430
            .:::.:||.|..|:||...|.. |.:....:.|.:::.::  .:|.:....:.:|||:|||.|.:
Zfish   929 YKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCA 993

  Fly   431 GVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHG 495
            ||:|....::.::...|:.::|:|:.|...::|||..|.::|.....|:   .:.|.|..::..|
Zfish   994 GVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQ---LELRGDVEMKGKG 1055

  Fly   496 -IRTF-LIKSLRA 506
             :||: |:..::|
Zfish  1056 KMRTYWLLGEVKA 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	47/228 (21%)
		CYCc	254..476	CDD:214485	60/238 (25%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	50/186 (27%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
npr1b	XP_009290669.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900