DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and Adcy4

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_062158.2	Gene:	Adcy4 / 54223	RGDID:	2034	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	1097	Identity:	292/1097 - (26%)
Similarity:	477/1097 - (43%)	Gaps:	273/1097 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 YTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQ---MHSILNEAIYLSCVNLLG 224
            :.::.:|..:|:. :......|...:..:::.....:..:.::|   :..:...|:...|.|::|
  Rat   125 FIIFTVYAMLPLG-MRDAAAAGVISSLSHLLVLGLYLGWRPESQRDLLPQLAANAVLFLCGNVVG 188

  Fly   225 IFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQ 289
            .:.:.:.:.|||.||.:....:.....|...:..:..||||||||.:|..::.::..|::..:..
  Rat   189 AYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQSS 253

  Fly   290 HQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHD 354
            ..:.:.                  :..:|:::.|:.|:|||||:|.:|.|.:....|:||..|::
  Rat   254 RPENTN------------------NFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNE 300

  Fly   355 LFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDM 419
            ||.:||..::|:..:|||.||||||||:||.....|||..||.:||.|.:.||.:|....::|:|
  Rat   301 LFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRVATGVDINM 365

  Fly   420 RIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEK 484
            |:|||||.||.||||..|||:|:||.||.:||.:||.|..||||::..||:||.|.|..|....:
  Rat   366 RVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVERADME 430

  Fly   485 AREDPVLQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTLHQYNQVRNQAKL 549
            .| ||.|::.|..|:|:       .||   ..|.:.:|.:|....:.:...|:        :..|
  Rat   431 HR-DPYLRELGEPTYLV-------IDP---WAEEEDEKGTERGLLSSLEGHTM--------RPSL 476

  Fly   550 EMCRELDK----MPIGRIQLT------------KVF--------RRSTRLTQDEIEEETFR---- 586
            .|.|.|:.    .|...:...            |.|        .|:.|...||::....:
  Rat   477 LMTRYLESWGAAKPFAHLSHVDSPASTSTPLPEKAFSPQWSLDRSRTPRGLHDELDTGDAKFFQV 541

  Fly   587 -------------RNISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLL----- 633
                         ::.:...|:||.:..|.||........||..|..:::::...|||:|
  Rat   542 IEQLNSQKQWKQSKDFNLLTLYFREKEMEKQYRLSALPAFKYYAACTFLVFLSNFTIQMLVTTRP 606

  Fly   634 ------------------------------SKDARYHYWY----------------IDGTTIILL 652
                                          .|..:..:|.                :...||:|:
  Rat   607 PALATTYSITFLLFLLLLFVCFSEHLTKCVQKGPKMLHWLPALSVLVATRPGLRVALGTATILLV 671

  Fly   653 TMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQ 717
            ..:.:||   .|::...||....:||  :|...|..|.|:..::.:..:.|.:    :|.|  :.
  Rat   672 FTMAVVS---LLFLPVSSDCPFLAPN--VSSVAFNTSWELPASLPLISIPYSM----HCCV--LG 725

  Fly   718 VVGCSSDEDYADLDPTYDERVQCFHPWILTNCMTLVIGMSF---LFTRIPFIIKSCFSALIMIGY 779
            .:.||                             |.:.|||   |...:.:::.||  :|.:..:
  Rat   726 FLSCS-----------------------------LFLHMSFELKLLLLLLWLVASC--SLFLHSH 759

  Fly   780 AVLVVSEFNFIYANSPST--NVNFNAKYSHILLMIITFGIFHLMERQTEFIAKVDYNWKRQLIKK 842
            |.|.......:|..|..:  .|....|....:...|.|....::.||.|:..::|:.||::|.::
  Rat   760 AWLSDCLIARLYQGSLGSRPGVLKEPKLMGAIYFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQE 824

  Fly   843 QEDALITNDTIKVLLTNILPTHVADFYLSNQLQNE-LYYEEYDNVAVMFASIKNF-------DTD 899
            :|:.....:..::||.|:||.|||..::....:|| ||::.|:.|.|:||||.:|       :.:
  Rat   825 REETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASIPDFKEFYSESNIN 889

  Fly   900 KIG---LRVLNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVS 961
            ..|   ||:|||||.|||::|:|...| .|||||....|||||.||:.:..:....
  Rat   890 HEGLECLRLLNEIIADFDELLSKPKFS-GVEKIKTIGSTYMAATGLNATPGQDTQQ--------- 944

  Fly   962 LMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNE 1026
                                                |.||              |.:|.|:
  Rat   945 ------------------------------------DAER--------------SCSHLGT---- 955

  Fly  1027 VVRVMAEFALDL---MRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWG 1088
                |.|||:.|   :..:.:.:..|.:           ||:|::||..:|||:|..||.|||||
  Rat   956 ----MVEFAVALGSKLGVINKHSFNNFR-----------LRVGLNHGPVVAGVIGAQKPQYDIWG 1005

  Fly  1089 NPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVKGRGNIPTYIIGID 1145
            |.||:||||:||||.|:|||||.||..|:.....|..||:..|||:|.:.||.:..|
  Rat  1006 NTVNVASRMESTGVLGKIQVTEETARALQSLGYTCYSRGVIKVKGKGQLCTYFLNTD 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	24/123 (20%)
		CYCc	254..476	CDD:214485	90/221 (41%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	88/181 (49%)
		CYCc	856..1117	CDD:214485	93/274 (34%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	93/276 (34%)
Adcy4	NP_062158.2	AC_N	<115..246	CDD:292831	23/121 (19%)
		CYCc	219..422	CDD:214485	90/220 (41%)
		Guanylate_cyc	264..430	CDD:278633	82/165 (50%)
		DUF1053	479..580	CDD:283888	15/100 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	498..523		2/24 (8%)
		CYCc	824..1039	CDD:214485	95/293 (32%)
		Guanylate_cyc	861..1060	CDD:278633	93/277 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920