DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and Phlpp2

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	419	Identity:	81/419 - (19%)
Similarity:	137/419 - (32%)	Gaps:	141/419 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 LSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQT----------LKRWRQPDHGTL 318
            :.|||.         |..:||..|:  :|.|.......|.:||          .:||::.
  Rat   230 MHILPL---------VGGKIEEVKR--RQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQ----- 278

  Fly   319 FIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIA--SEEYNVLRIKFLG--DCYY 379
                       .:.||:....|..|....|.|....||...||.  :..:|.::::..|  |..|
  Rat   279 -----------ASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLY 332

  Fly   380 CVAGLANPNADHAKCCVDLGL--RMIKDIRDVREKRHLNIDMRIGVH-----------------S 425
            ..:.|...|..|.|    |||  .::.:|..:.|   ||:... |.|                 .
  Rat   333 KFSQLKGLNLSHNK----LGLFPVLLCEISTLTE---LNLSCN-GFHDLPSQIGNLLNLQTLCLD 389

  Fly   426 GDVLSGV------------IGAAKWQFD----------IWSKDVDIANRLEA--TGATGRV-HVS 465
            |:||:.:            :|.:...|.          :..|.|...||||.  .|...|: ||.
  Rat   390 GNVLTALPDELGNLQQLTSLGISFNNFSQIPEVLEKLTMLDKVVMAGNRLEILNLGVLTRMNHVK 454

  Fly   466 QKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKAN 530
            ...|.:                      :.::|.:|::|....|.....:|:.|:..|..:|..
  Rat   455 HVDLRM----------------------NHLKTVIIENLEGNKHITHMDLRDNQLTDLDLSSLC- 496

  Fly   531 FMHNSTLHQYNQVRNQAKLEMCRELDKMPIGRIQLTKVFRRSTRLTQDEI-------EEETFRRN 588
                 :|.|.:..|||        |.::.:....|..::....:||...:       ......||
  Rat   497 -----SLEQLHCERNQ--------LRELTLSGFSLRNLYANWNKLTAVNVYPVPSLLTSLELSRN 548

  Fly   589 ISSCCLFFRIRNWEFQYIKEPDVMLKYSI 617
            :..|     |.:|..:..|...:.:.|::
  Rat   549 LLEC-----IPDWACEAKKLEILDISYNL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	4/19 (21%)
		CYCc	254..476	CDD:214485	57/269 (21%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	45/229 (20%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761
		PH_PHLPP-like	185..279	CDD:270131	14/75 (19%)
		PLN00113	284..>762	CDD:215061	65/338 (19%)
		leucine-rich repeat	289..309	CDD:275380	6/19 (32%)
		leucine-rich repeat	310..336	CDD:275380	5/25 (20%)
		leucine-rich repeat	337..359	CDD:275380	8/25 (32%)
		leucine-rich repeat	360..382	CDD:275380	5/25 (20%)
		leucine-rich repeat	383..405	CDD:275380	3/21 (14%)
		leucine-rich repeat	406..428	CDD:275380	2/21 (10%)
		leucine-rich repeat	429..452	CDD:275380	8/22 (36%)
		leucine-rich repeat	453..476	CDD:275380	5/44 (11%)
		leucine-rich repeat	477..497	CDD:275380	4/25 (16%)
		leucine-rich repeat	498..517	CDD:275380	6/26 (23%)
		leucine-rich repeat	518..539	CDD:275380	3/20 (15%)
		leucine-rich repeat	540..562	CDD:275380	5/26 (19%)
		leucine-rich repeat	563..584	CDD:275380	1/10 (10%)
		leucine-rich repeat	586..607	CDD:275380
		leucine-rich repeat	608..631	CDD:275380
		leucine-rich repeat	632..681	CDD:275380
		leucine-rich repeat	682..705	CDD:275380
		leucine-rich repeat	706..728	CDD:275380
		leucine-rich repeat	751..772	CDD:275380
		PP2Cc	820..1069	CDD:238083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900