DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and NPR3

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001191304.1	Gene:	NPR3 / 4883	HGNCID:	7945	Length:	541	Species:	Homo sapiens

Alignment Length:	324	Identity:	58/324 - (17%)
Similarity:	108/324 - (33%)	Gaps:	96/324 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   802 NAKYSHIL-----------LMIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKV 855
            :::|||:.           :|:..|...|               |.|..:...:|.|..|
Human   168 DSEYSHLTRVAPAYAKMGEMMLALFRHHH---------------WSRAALVYSDDKLERN----- 212

  Fly   856 LLTNILPTHVADFYLSNQLQNELYYEEYDNVAVMFASIKNFDTDKIGLRVLNEIICDFDDVLNKY 920
                        .|.:.:..:|::.||     .:..||.:||..|         ..|.:|::...
Human   213 ------------CYFTLEGVHEVFQEE-----GLHTSIYSFDETK---------DLDLEDIVRNI 251

  Fly   921 SQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRV 985
            ..|.||..:..::.|..:.  :.|:....:.:....|.|:.|.           .||:
Human   252 QASERVVIMCASSDTIRSI--MLVAHRHGMTSGDYAFFNIELF-----------NSSS------- 296

  Fly   986 PYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRR--FNTE 1048
             ||:||       .:||  :.:...:....||....:....|.....:|::::..::.:  .|.|
Human   297 -YGDGS-------WKRG--DKHDFEAKQAYSSLQTVTLLRTVKPEFEKFSMEVKSSVEKQGLNME 351

  Fly  1049 NMQTEY-EGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTEN 1111
            :....: ||..|..:|.:...|....|   |.||..   .|..:.........|:.||:.:..|
Human   352 DYVNMFVEGFHDAILLYVLALHEVLRA---GYSKKD---GGKIIQQTWNRTFEGIAGQVSIDAN 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831
		CYCc	254..476	CDD:214485
		Nucleotidyl_cyc_III	321..503	CDD:299850
		CYCc	856..1117	CDD:214485	47/259 (18%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	45/237 (19%)
NPR3	NP_001191304.1	PBP1_NPR_C_like	54..446	CDD:107381	58/324 (18%)
		ANF_receptor	71..422	CDD:279440	58/324 (18%)
		TM_EphA1	476..507	CDD:214014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900