DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and NPR2

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_024303324.1	Gene:	NPR2 / 4882	HGNCID:	7944	Length:	1103	Species:	Homo sapiens

Alignment Length:	465	Identity:	102/465 - (21%)
Similarity:	194/465 - (41%)	Gaps:	127/465 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VVLGVNF-RSELVSKHGWVVYATSWLAVC------VMVLMDIGLNVYHATSHNDILNPIYDAYTL 165
            :|.|:.| .:.::|.||.:..:.     |      |:.:.|.||..:.:|:..|      |::.|
Human   630 LVKGMAFLHNSIISSHGSLKSSN-----CVVDSRFVLKITDYGLASFRSTAEPD------DSHAL 683

  Fly   166 YA--------IYMFMPVP-------------YLLQPFVLGSA-VTFCYIINYSF---VITAKDDN 205
            ||        :::.:..|             ..:.|..||.| ....:...:.|   :.||.:..
Human   684 YASEAHPHNPLFILLLFPPRDGGRGRWSDSNIGMSPGGLGGAPFRGTWPAGFLFSEKLWTAPELL 748

  Fly   206 QMHSILNEAIYLSCVNLLGIFFRLMRDIALRT----------------------------TFLDR 242
            ..:.:....:..:.|...||   ::::||||:                            ..:||
Human   749 SGNPLPTTGMQKADVYSFGI---ILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDR 810

  Fly   243 RQYVEENLLL-----------------------RYARDQERSLLLSIL--PAQIADRLQEDVKNR 282
            .|..||.:||                       |:.::...|:|.::|  ..|.|:.|::.|:.|
Human   811 TQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEER 875

  Fly   283 IERSKQQHQQQSQVDLRRSAD-----------SQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNY 336
                     .|:.::.:|.|:           ::.|||..     |:..|..:.||:.::|:|.:
Human   876 ---------TQAYLEEKRKAEALLYQILPHSVAEQLKRGE-----TVQAEAFDSVTIYFSDIVGF 926

  Fly   337 THLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNAD-HAKCCVDLGL 400
            |.|:......::|..|:||:..||...:.::|.:::.:||.|..|:||...|.. ||.....:.|
Human   927 TALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMAL 991

  Fly   401 RMIKDIRD--VREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVH 463
            .::..:..  :|.:.|..:.:|||||:|.|.:||:|....::.::...|:.|:|:|:.|...::|
Human   992 ALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIH 1056

  Fly   464 VSQKTLSLLD 473
            ||..|...||
Human  1057 VSSTTKDALD 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	48/260 (18%)
		CYCc	254..476	CDD:214485	62/236 (26%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	47/156 (30%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
NPR2	XP_024303324.1	Periplasmic_Binding_Protein_Type_1	26..421	CDD:324556
		PK_GC-A_B	521..848	CDD:270944	40/231 (17%)
		HNOBA	<857..902	CDD:311573	9/53 (17%)
		CYCc	881..1065	CDD:214485	51/188 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900