DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and Gycalpha99B

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_477088.2	Gene:	Gycalpha99B / 43493	FlyBaseID:	FBgn0013972	Length:	676	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	127/580 - (21%)
Similarity:	207/580 - (35%)	Gaps:	177/580 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 YFDSAIEYN-----RSNPISLART---------SSQAQTVQNE-----KNWEWSYLVRKCRNLEL 49
            |..|.::.|     ...|.|:::|         ||.|..:|..     |.:.|.:::.:  .|||
  Fly   220 YLFSLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSNASDLQMNSSSFCKMFPWHFIMNE--QLEL 282

  Fly    50 -------EDSYDLYMRRLRVGYLSLFIFIH-----------VAVTVIHTLLLLTTPEIKYVYVDM 96
                   ...|..||........:.|.|..           |..|....|:.|..|
  Fly   283 VQLGRGFSKLYKPYMADFGCQATTYFDFKRPKGLTMKFRDIVRRTYTPFLIGLNNP--------- 338

  Fly    97 VAYMCSGLVIWVVLGVNFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYD 161
                 .|.|.:..:|:..:.::|                            |....|.:|
  Fly   339 -----PGAVDFPAIGLEIKGQMV----------------------------HCPESNSLL----- 365

  Fly   162 AYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAIYLSCVNLLGIF 226
                          ::..||:.|.....|   |..|:    .|..:|....|.|      |:|..
  Fly   366 --------------FIGSPFLDGLDGLTC---NGLFI----SDIPLHDATREVI------LVGEQ 403

  Fly   227 FRLMRDIALRTTFLDR-RQYVEE-NLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQ 289
            .|....:..|   :|: :..:|| |..:...|.:..|||..|.||:||::|.
  Fly   404 ARAQDGLRRR---MDKIKNSIEEANSAVTKERKKNVSLLHLIFPAEIAEKLW------------- 452

  Fly   290 HQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHD 354
                    |..|.|::|                :.|||:|::|:|.:|.:.:......::..|..
  Fly   453 --------LGSSIDAKT----------------YPDVTILFSDIVGFTSICSRATPFMVISMLEG 493

  Fly   355 LFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHL---- 415
            |:..||...:.::|.:::.:||.|...:||...:...|.....:.|:||    |...| |:
  Fly   494 LYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWMALKMI----DACSK-HITHDG 553

  Fly   416 -NIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFE 479
             .|.||||:|:|.||:||:|....::.::...|.|||:.|:.....:::||..|...|.....||
  Fly   554 EQIKMRIGLHTGTVLAGVVGRKMPRYCLFGHSVTIANKFESGSEALKINVSPTTKDWLTKHEGFE 618

  Fly   480 DGTEKAREDP-VLQKH-----GIRT-FLIKSLRAPMHDPRRRMRER---QVKKLSEASKA 529
              .|....|| .|.|.     |..| :.::|.|.|..|....:.|.   .:|.:||...|
  Fly   619 --FELQPRDPSFLPKEFPNPGGTETCYFLESFRNPALDSELPLVEHINVSMKTISEGGDA 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	48/261 (18%)
		CYCc	254..476	CDD:214485	59/226 (26%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	54/193 (28%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
Gycalpha99B	NP_477088.2	HNOB	76..208	CDD:285002
		HNOBA	259..451	CDD:285003	50/270 (19%)
		CYCc	430..619	CDD:214485	61/232 (26%)
		Guanylate_cyc	457..647	CDD:278633	56/212 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740