Protein Alignment ACXD and Adcy1

DIOPT Version :9

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_033752.1
• Gene: Adcy1 / 432530
• MGIID: 99677
• Length: 1118
• Species: Mus musculus
• Alignment Length: 1070
• Identity: 288/1070 - (26%)
• Similarity: 467/1070 - (43%)
• Gaps: 279/1070 - (26%)

  Fly   166 YAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAIYLSCVNLLGIFFRLM 230
            :..|..:||..|| ....|..|...:::..:.::.||......::...|:....||:.|:|.|::
Mouse   170 FVSYALLPVRSLL-AIGFGLVVAASHLLVTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRIL 233

  Fly   231 RDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQ 295
            .:.:.|..||..|..:|:.|.|....:::..||:|:||..:|..::||.....||...:
Mouse   234 TERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHK------ 292

  Fly   296 VDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFD 360
                                  ::|:.|::|::|:||:|.:|.|.:....::||:.|::||.:||
Mouse   293 ----------------------IYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFD 335

  Fly   361 IASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHS 425
            ..:.|.:..|||.||||||||:||..|..|||.|||::||.||..|..|.|...::::||:|:|:
Mouse   336 ELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHT 400

  Fly   426 GDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPV 490
            |.||.||:|..|||:|:||.||.:||.:||.|..|:||:::.||:.|:|:|..|.|....| :..
Mouse   401 GRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHER-NTF 464

  Fly   491 LQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNST----LHQYNQVRNQAKLEM 551
            |:.|.|.||.|    .|.|  ||::....:  ||:...|..|...|    |.|....|...|.|:
Mouse   465 LRTHNIETFFI----VPSH--RRKIFPGLI--LSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEI 521

  Fly   552 -------CRELDKMPIGRIQLTKVFRRSTRLTQDEI-EEETFRRNISSCCLFFRIRNWEFQYIKE 608
                   |.:.||            ||:.|...::: ...:|..|:.......|:..:..:.::.
Mouse   522 PFSNVMTCEDDDK------------RRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEA 574

  Fly   609 PDVMLKYSIALAWVIYMGLLTIQL--LSKDARYHYWYIDGTTIILLTMLLIVSWYKKLWIMYMSD 671
            ....|:       :..:...|::.  :.::.:||....:..|..::..|::.:.:..::::.:..
Mouse   575 RQTELE-------MADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILAALFGLIYLLVIPQ 632

  Fly   672 ADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGCSSDEDYADLDPTYDE 736
            :                           |.:..|::||.|.     :|.|:.   |..:     .
Mouse   633 S---------------------------VAVLLLLVFSICF-----LVACTL---YLHI-----T 657

  Fly   737 RVQCFHPWILTNCMTLVIGMS---FLFTRIPFIIKSCF-------------SALIMIG------- 778
            |||||     ..|:|:.|..:   |:...|..:.:.|.             |:|:::.
Mouse   658 RVQCF-----PGCLTIQIRTALCVFIVVLIYSVAQGCVVGCLPWAWSSQSNSSLVVLAAGGRRTV 717

  Fly   779 ----------YAVL--------------------------VVSEFNFIYANSPSTNVNFNA---- 803
                      :|:|                          :.:.:..:...|..|.|...|
Mouse   718 LPALPCESAHHALLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGR 782

  Fly   804 KYSHILLMIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVAD- 867
            .|..|:.:::......|..||.:...::||.|..|..::::|........|.:|.|:||.|||.
Mouse   783 SYEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQH 847

  Fly   868 FYLSNQLQNELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNK--Y 920
            |.:||....:|||:.|..|.||||||.||       |.:.:|   ||:|||||.|||::::|  |
Mouse   848 FLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFY 912

  Fly   921 SQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRV 985
            ..   :||||....|||||.||         ||
Mouse   913 KD---LEKIKTIGSTYMAAVGL---------AP-------------------------------- 933

  Fly   986 PYGNGSNIALDLDLERGQYEGNVITSGPRIS---STHNGSSSNEVVRVMAEFALDLMRTMRRFNT 1047
                                    |:|.|..   |:|        :..:|:||:|:...:...|
Mouse   934 ------------------------TAGTRAKKSISSH--------LCTLADFAIDMFDVLDEIN- 965

  Fly  1048 ENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENT 1112
                  |:...|: :||:||:.|..:|||:|..:|.||||||.||:|||||||||.|:|||||..
Mouse   966 ------YQSYNDF-VLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEV 1023

  Fly  1113 ALKLREFNIQCNYRGMTFVKGRGNIPTYII 1142
            ...|:..:.|...||...|||:|.:.||.:
Mouse  1024 HRLLKRCSYQFVCRGKVSVKGKGEMLTYFL 1053

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	30/117 (26%)
		CYCc	254..476	CDD:214485	84/221 (38%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	83/181 (46%)
		CYCc	856..1117	CDD:214485	95/276 (34%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	95/278 (34%)
Adcy1	NP_033752.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		AC_N	<158..291	CDD:292831	32/121 (26%)
		CYCc	257..452	CDD:214485	84/222 (38%)
		Guanylate_cyc	293..475	CDD:278633	83/182 (46%)
		Interaction with calmodulin. /evidence=ECO:0000250	492..519		6/26 (23%)
		CYCc	825..1036	CDD:214485	98/294 (33%)
		Guanylate_cyc	858..1055	CDD:278633	95/280 (34%)
		Interaction with calmodulin. /evidence=ECO:0000250	1023..1046		7/22 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1079..1118

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810