DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and Gyc88E

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001036711.1	Gene:	Gyc88E / 41825	FlyBaseID:	FBgn0038295	Length:	1097	Species:	Drosophila melanogaster

Alignment Length:	688	Identity:	138/688 - (20%)
Similarity:	259/688 - (37%)	Gaps:	217/688 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LARTSSQAQTVQNEKNWE-----------------------WSYLVRKCRNL------ELEDSYD 54
            |...|...::|..|:.||                       ...|.:|.:.:      :..|...
  Fly     6 LENLSEYIKSVYGEEKWEDIRRQAGIDSPSFSVHQVYPENLLQKLAKKAQQVLGVSERDFMDQMG 70

  Fly    55 LYMRRLRVGYLSLFIFIHVAVTV-------------IHTLLLLTTPEIKYVYVDMVAYMC----- 101
            :|.    ||::..:.:..|...:             :|..|..:.|.::     ..:::|
  Fly    71 VYF----VGFVGQYGYDRVLSVLGRHMRDFLNGLDNLHEYLKFSYPRMR-----APSFICENETK 126

  Fly   102 SGLVIWVVLGVNFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNP--IYD--- 161
            .||.:      ::||:   :.|:|.|...       .:.::....||...|.:::..  ::|
  Fly   127 QGLTL------HYRSK---RRGFVYYTMG-------QIREVARYFYHKEMHIELVREEILFDTVH 175

  Fly   162 ----------AYTLYAIYMFMPVPYL-LQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAI 215
                      |:||.::.|.....:| :...||.....||.:.....|:.: ..|.:..||.|
  Fly   176 VTFQLTFDNRAFTLASLAMTREEKHLPISAHVLFEIFPFCMVFGADMVVRS-IGNSLMVILPE-- 237

  Fly   216 YLSCVNLLG----IFFRLMRD-IALR-TTFLDR---------------RQYVEENLLLRY--ARD 257
                  |||    .:|.|:|. ||.: .|.|:|               |..|:...||::  ..:
  Fly   238 ------LLGKKITAWFDLVRPLIAFKFQTILNRTNNIFELVTVDPVTERFDVQNEDLLQHEDGSE 296

  Fly   258 QERSLLLS------------------ILP---------AQIADRLQEDVKN-----------RIE 284
            .|:||.|.                  ::|         ..|.|....|...           .::
  Fly   297 PEKSLRLKGQMVYMENWRMIMFLGTPVMPDLTSLITTGLYINDLSMHDFSRDLMLAGTQQSVELK 361

  Fly   285 RSKQQHQQQSQ----------VDLRRSAD-------SQTLKRWRQPDHGTLFIEPHEDVTVLYAD 332
            .:..|.||:|:          .::||:.:       .|...|.|:.::.....|..:.|::|::|
  Fly   362 LALDQEQQKSKKLEESMRLLDEEMRRTDELLYQMIPKQVADRLRRGENPIDTCEMFDSVSILFSD 426

  Fly   333 VVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVD 397
            :|.:|.:.:.:...::|..|:.::..||..:|..:|.:::.:||.|..|||..:.:|:||:...|
  Fly   427 IVTFTEICSRITPMEVVSMLNAMYSIFDKLTERNSVYKVETIGDAYMVVAGAPDKDANHAERVCD 491

  Fly   398 LGLRM---IKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGAT 459
            :.|.|   |.|::|....:||.|  |:|||||.|::|::|....::.::...|:.|:|:|:|...
  Fly   492 MALDMVDAITDLKDPSTGQHLRI--RVGVHSGAVVAGIVGLKMPRYCLFGDTVNTASRMESTSIA 554

  Fly   460 GRVHVSQKTLSLLD-------------------GEYFFEDGTEKARED-------PVLQKHGIR- 497
            .:||:|:.|..|:.                   |.|:.|:     ||:       ..||.|.:.
  Fly   555 MKVHISESTKVLIGPNYKIIERGEIDVKGKGTMGTYWLEE-----RENRLPLQLTAALQVHPLSP 614

  Fly   498 -----TFLIKSLRAPMHDPRRRMRERQVKKLSEASKAN 530
                 |...|::..|:..|...|....|...:....:|
  Fly   615 VPPTPTPKTKAIMPPVSKPLTPMMPVSVSLAASMPTSN 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	58/342 (17%)
		CYCc	254..476	CDD:214485	67/300 (22%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	58/216 (27%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
Gyc88E	NP_001036711.1	HNOB	2..164	CDD:311572	27/182 (15%)
		HNOBA	201..404	CDD:311573	40/211 (19%)
		CYCc	383..571	CDD:214485	54/189 (29%)
		Herpes_ICP4_C	794..>955	CDD:332854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453999
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740