Protein Alignment ACXD and rut

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_511156.2
• Gene: rut / 32406
• FlyBaseID: FBgn0003301
• Length: 2248
• Species: Drosophila melanogaster
• Alignment Length: 1335
• Identity: 336/1335 - (25%)
• Similarity: 548/1335 - (41%)
• Gaps: 383/1335 - (28%)

  Fly     6 DSAIEYNRSNPISLARTSSQAQTVQNEKNWEWSYLVRKCRNLELEDSYDLYMRRL-RVGYLSLFI 69
            |.|::..|..|::..|                      ..|.|||..|..|..:| |...|.:..
  Fly     2 DHAVKATRGRPLNTLR----------------------FENDELECLYQRYTLKLQRFSVLGVVA 44

  Fly    70 FIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSGLVIWVVLGVNFRSELVSKH-------GWVVY 127
            .:.|...|: ..|.||.......:....|.:|.   ::.|:.|..:..::..|       |.:::
  Fly    45 LVFVLCGVM-AALSLTFNNAATFHNIFNAIVCG---LFAVVLVLLQCSVIKDHHLPTLCYGILLF 105

  Fly   128 ATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYD-AYTLYAIYMFMPVPYLLQPFVLGSAVTFCY 191
            ..|   :||:.:..:| :|:...:...:...::. .:.::..|..||: .:.:....|.|:...:
  Fly   106 TAS---ICVVSMPTLG-SVFPVDTKEVMAEGVWQIVFVVFLAYAMMPL-QIWEAVAFGIALPSVH 165

  Fly   192 II-----NYSFVITAKDDNQMHSILNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLL 251
            |.     .::..:...:.||:  |.|..|::. ||:.|:...:|.:.|.|.||||.|..:...|.
  Fly   166 ISLTVYKIFTDALRYLEYNQL--IANIVIFIG-VNVAGLVVNIMMERAQRRTFLDTRNCIASRLE 227

  Fly   252 LRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHG 316
            ::...::...||||:||..:|.:::.|:.:.:  :.|.|:
  Fly   228 IQDENEKLERLLLSVLPQHVAMQMKNDILSPV--AGQFHR------------------------- 265

  Fly   317 TLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCV 381
             ::|:.||:|::|:||:|.:|.|::....::||..|::||.|||..:.:.:.||||.||||||||
  Fly   266 -IYIQKHENVSILFADIVGFTVLSSQCSAQELVRLLNELFGRFDQLAHDNHCLRIKILGDCYYCV 329

  Fly   382 AGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKD 446
            :||..|..|||||.|::||.||..|..|.|...:.::||:|:|:|.||.||:|..|||||:||.|
  Fly   330 SGLPEPRKDHAKCAVEMGLDMIDAIATVVEATDVILNMRVGIHTGRVLCGVLGLRKWQFDVWSND 394

  Fly   447 VDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLI---KSLRAPM 508
            |.:||.:|:.|..|||||::.||..|.|||..|.|....|.. .|:.||:.||.|   ...|.|:
  Fly   395 VTLANHMESGGEPGRVHVTRATLDSLSGEYEVEAGHGDERSS-YLRDHGVDTFFIVPPPHRRKPL 458

  Fly   509 H----------DPRRRMRERQVKKL---------------------------------------- 523
            .          ..||::..|.|..:
  Fly   459 MLNTLGVRSAIGSRRKLSFRNVSNVVMQLLHTIKFSEPVPFSNIATGSFPSAASALGGGVSVGGG 523

  Fly   524 -------------SEASKAN----------------FMH-------------------------- 533
                         .||:..|                .:|
  Fly   524 GGGGGGGVARGSTCEANSGNVQVSEKGSRKVIRLQKILHATPPPHGMGYGSVVGSGGGVDSGISG 588

  Fly   534 -----------------------NST------LHQYNQVRNQAKLEMCRELDK------------ 557
                                   |||      :|::|...|:::.::..:..:
  Fly   589 GGGCVSGGIAGGGGVQVTVGTNPNSTASTISRIHRHNHKNNKSQSKVADKFKRPFRKRHSVAAHH 653

  Fly   558 MPIGRIQ--LTKVFR-RSTRLTQDEIEEETFRRNISSCCLFFRIRNWEFQYIKEPDVMLKYSIAL 619
            .|..|:.  |::... ||....:.|        ::....|.||..:.|.:|.|:.|        |
  Fly   654 QPTNRVNRFLSQAINARSVDCDKSE--------HVDRLTLRFRQSDMEREYHKDFD--------L 702

  Fly   620 AWVIYMGLLTIQLLSKDARYHYWYIDGTTIILLTMLLIVSWYKKLWIMYMSDADVSSPNGRLSGF 684
            .:...|| .::.||...|......:..|.|:||..|....|...:.::.::        .||...
  Fly   703 GFTTAMG-CSLLLLILGAALQVTALPRTLILLLLFLFAFIWVSAILMLLLA--------VRLKWI 758

  Fly   685 LFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGCSSDEDYADLDPT---YDERVQCFHPWIL 746
            ::.:|:.....:.|.:   |.:|..| :|..:.|..|.||...:....|   .|...:|..|
  Fly   759 IWDISESFSLRMAITI---FTVILIY-SVGQVNVFTCVSDHPCSGNGTTSFQNDSHRKCSLP--- 816

  Fly   747 TNCMTLVIGMSFL----FTRIPFIIKSCFSALIMIG----YAVLV-VSEFNFI--YANSPSTNVN 800
             ..::|....:||    |.|:|.|.||    |:::|    |.:.: :|..|..  |.|..:.::.
  Fly   817 -QYVSLSAAFAFLSVSVFLRLPIIFKS----LLVLGMGTIYGLFIELSHQNIFECYDNRVNASIP 876

  Fly   801 FN----AKYSHILLMIITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNIL 861
            .:    |:.:..::.|:..|      |..|..|::|:.|:.|..:::::..:..::.|.:|.|:|
  Fly   877 LHLISLARIAIFMIAILVHG------RLVEGTARLDFLWQLQASQEKKEMDVLQESNKRILHNLL 935

  Fly   862 PTHVADFYLSNQLQN--ELYYEEYDNVAVMFASIKNFD---TDKIG-------LRVLNEIICDFD 914
            |.|||..:|..|.:|  |||::.|..|.|:|||:.||:   |:..|       ||:|||||.|||
  Fly   936 PAHVAAHFLDAQFRNNMELYHQSYAKVGVIFASVPNFNEFYTEMDGSDQGLECLRLLNEIIADFD 1000

  Fly   915 DVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNA 979
            ::| |..:...::|||....||||..||         .|:.|     :.||
  Fly  1001 ELL-KEDRFRGIDKIKTVGSTYMAVVGL---------IPEYK-----IQPN-------------- 1036

  Fly   980 DGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRR 1044
                                                       ..|.|.|.|... ::.::.||
  Fly  1037 -------------------------------------------DPNSVRRHMTAL-IEYVKAMR- 1056

  Fly  1045 FNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVT 1109
               .::|.....|.:..|||:||:.|..:|||:|..||.||||||.||:|||||||||||..|||
  Fly  1057 ---HSLQEINSHSYNNFMLRVGINIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPGYSQVT 1118

  Fly  1110 ENTALKL--REFNIQCNYRGMTFVKGRGNIPTYII 1142
            :.....|  ..|..:|  ||...|||:|::.||.:
  Fly  1119 QEVVDSLVGSHFEFRC--RGTIKVKGKGDMVTYFL 1151

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	56/255 (22%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	88/184 (48%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	90/275 (33%)
rut	NP_511156.2	AC_N	<17..255	CDD:318454	56/271 (21%)
		Guanylate_cyc	266..428	CDD:425528	80/161 (50%)
		Adcy_cons_dom	624..698	CDD:461877	13/81 (16%)
		AcyC	742..1150	CDD:441717	143/512 (28%)
		Guanylate_cyc	954..1151	CDD:425528	90/275 (33%)