DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACXD and GUCY2D

DIOPT Version :9

Sequence 1:NP_620469.2 Gene:ACXD / 38284 FlyBaseID:FBgn0040507 Length:1162 Species:Drosophila melanogaster
Sequence 2:NP_000171.1 Gene:GUCY2D / 3000 HGNCID:4689 Length:1103 Species:Homo sapiens


Alignment Length:299 Identity:78/299 - (26%)
Similarity:139/299 - (46%) Gaps:59/299 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 QIADRLQEDVKNRIERSKQQHQQQSQV--DLRRSADSQTLKRWRQPDHGTLFIEPH--EDVTVLY 330
            |.:..|::.::.|.|..:.:.|:..::  .:...:.::.||.      ||. :||.  |.||:.:
Human   826 QYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKT------GTP-VEPEYFEQVTLYF 883

  Fly   331 ADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNAD-HAKC 394
            :|:|.:|.::...:..::|:.|:||:..||.....::|.:::.:||.|...:||...|.. ||..
Human   884 SDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAE 948

  Fly   395 CVDLGLRMIKDIRDVREKRHL---NIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEAT 456
            ..::.|.::..:...| .||:   .:.:|||:|||..::||:|....::.::...|:.|:|:|:|
Human   949 IANMSLDILSAVGTFR-MRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMEST 1012

  Fly   457 GATGRVHVSQKTLSL---LDGEYFFE--DGTE---KARED-----------------PVLQ---- 492
            |...|:||:..|:.:   ||..|..|  ..||   |..||                 |.||    
Human  1013 GLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPGSS 1077

  Fly   493 KHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANF 531
            .|||....|        .|.||      :||.:|....|
Human  1078 NHGISLQEI--------PPERR------RKLEKARPGQF 1102

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXDNP_620469.2 AC_N <42..284 CDD:292831 3/13 (23%)
CYCc 254..476 CDD:214485 57/216 (26%)
Nucleotidyl_cyc_III 321..503 CDD:299850 62/216 (29%)
CYCc 856..1117 CDD:214485
Nucleotidyl_cyc_III 878..1142 CDD:299850
GUCY2DNP_000171.1 PBP1_sensory_GC_DEF-like 55..431 CDD:380594
PK_GC-2D 536..811 CDD:270945
HNOBA <820..865 CDD:369471 5/38 (13%)
CYCc 846..1036 CDD:214485 53/197 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1065..1103 14/52 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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