DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and GUCY1A1

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens

Alignment Length:	431	Identity:	99/431 - (22%)
Similarity:	175/431 - (40%)	Gaps:	86/431 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 AVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAV----TFCYII 193
            |..|:...::.:::.....|||....:...|.||:::|....|.|.......|.|    .||...
Human   222 AAHVLYETEVEVSLMPPCFHNDCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTF 286

  Fly   194 NYSFVITAKD------DNQMHSILNEAIYLSCVN---------------LLGIFFRLMRDIALRT 237
            .:.|:.. ||      .|.:..::|...:....|               ..||...|.....:|.
Human   287 PFHFMFD-KDMTILQFGNGIRRLMNRRDFQGKPNFEEYFEILTPKINQTFSGIMTMLNMQFVVRV 350

  Fly   238 TFLDRR---------------QYVEENLLL--------RYARDQERSLLLSILPAQIA------- 272
            ...|..               ..||.:.:|        |......|.|.||.:|...|
Human   351 RRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLI 415

  Fly   273 ---DRLQEDVKNRIERSK---QQHQQQSQVDLRRSAD----------SQTLKRWRQPDHGTLFIE 321
               .|.|:.:|.|:.:.|   :|..|..:.:.:::.|          :|.|  |:..   .:..:
Human   416 GEQARAQDGLKKRLGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQL--WQGQ---VVQAK 475

  Fly   322 PHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLAN 386
            ...:||:|::|:|.:|.:.:.....:::..|:.|:.|||....|.:|.:::.:||. |||||..:
Human   476 KFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDA-YCVAGGLH 539

  Fly   387 PNAD-HAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIA 450
            ..:| ||.....:.|:|::...:|.......|.||||:|||.|.:||:|....::.::..:|.:|
Human   540 KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 604

  Fly   451 NRLEATGATGRVHVSQKTLSLL---DGEYFFEDGTEKARED 488
            |:.|:.....:::||..|..||   .|..|    |.::||:
Human   605 NKFESCSVPRKINVSPTTYRLLKDCPGFVF----TPRSREE 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	40/208 (19%)
		CYCc	254..476	CDD:214485	65/248 (26%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	52/172 (30%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	32/189 (17%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	52/175 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810