Protein Alignment ACXD and Adcy8

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_058838.1
• Gene: Adcy8 / 29241
• RGDID: 2036
• Length: 1248
• Species: Rattus norvegicus
• Alignment Length: 1204
• Identity: 350/1204 - (29%)
• Similarity: 544/1204 - (45%)
• Gaps: 272/1204 - (22%)

  Fly    34 NWEWSY-------LVRKCRNLELEDSYDLYM----RRLRVGYLSLFIFIHVAVTVIHTLLLLTTP 87
            |..:||       |....::.:||..|..|.    |:..|....|.:...:.:.|:| |.|.:.|
  Rat   141 NGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLH-LSLASAP 204

  Fly    88 --EIKYVYVDMVAYMCSGLVIWVVLGVNFRSELVSKHGWVVYA--TSWLAVCVMVL---MDIGLN 145
              .:|.:.:...    :|:.:.:...|..|.:..| |.::.|:  .:|:|:...:|   :..||
  Rat   205 MDPLKGILLGFF----TGIEVVICALVVVRKDTTS-HTYLQYSGVVTWVAMTTQILAAGLGYGL- 263

  Fly   146 VYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSI 210
                  ..|.:.  |..:||:|.|..:|:|  |...:|....|....:....:|.......::.:
  Rat   264 ------LGDGIG--YVLFTLFATYSMLPLP--LTWAILAGLGTSLLQVTLQVLIPRLAVFSINQV 318

  Fly   211 LNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRL 275
            |.:.:...|:|..|||...:.|.|.|..||:.|:.||..|.|.....::..|:||:||..:...:
  Rat   319 LAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEM 383

  Fly   276 QEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLT 340
            ..|:.| :|....|||                       ...::|..:|:|::|:|||..:|:|:
  Rat   384 INDMTN-VEDEHLQHQ-----------------------FHRIYIHRYENVSILFADVKGFTNLS 424

  Fly   341 TTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKD 405
            |||..::||..|::||.|||..:.|::.||||.||||||||:||..|..|||.|||::||.|||.
  Rat   425 TTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKT 489

  Fly   406 IRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLS 470
            ||.||.:...::|||||:|||.||.||:|..|||||:||.||||||:||:.|..||:|:|:.||.
  Rat   490 IRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLD 554

  Fly   471 LLDGEYFFEDGTEKAREDPVLQKHGIRTFLIKS-----LRAPMHDPRRRM----RERQVKKLSEA 526
            .|.|:|..|:|..|.|.: .|:||.|.|:|||.     |..|....:..:    |.......:|.
  Rat   555 CLSGDYNVEEGHGKERNE-FLRKHNIETYLIKQPEESLLSLPEDIVKESVSCSDRRNSGATFTEG 618

  Fly   527 S------------KANFMHNSTLHQYNQVRNQAKLEM-----CRELDKMPIGRIQLTKVFRRSTR 574
            |            |.|.:...|.:..|.:.|.....:     ..|::|    ||:.|...|...:
  Rat   619 SWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINK----RIEHTIDLRSGDK 679

  Fly   575 LTQDEIEEETFRRNISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLLSKDARY 639
            |.         |.:|....|.|:..:.|.:|.:..|.:.|.::..|:::.:.:..||.|...:|.
  Rat   680 LR---------REHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRL 735

  Fly   640 HYWYIDGTTIILLTMLLIV----SWYKKL---------WI--MYMSDADVSSPNGRLSGFLFRMS 689
            ....|..:.:|:|...|::    ..||.|         ||  .|::
  Rat   736 MPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLA------------------- 781

  Fly   690 DEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGCSSDEDYADLDPTYDERVQ----CFHP--WILTN 748
                |||:|    :..|:.::.. |::.::.|..|:.....:.|::....    |.:|  ::.|.
  Rat   782 ----RNVII----FASILINFLG-AVINILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG 837

  Fly   749 CMTLVIGMSFLFTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNFN--------AKY 805
            .:.:|....||  |:..::|.....:::..||:|..:    |||....:..|.|        .|.
  Rat   838 VLAMVTCAVFL--RLNSVLKLAVLLIMIAIYALLTET----IYAGLFLSYDNLNHSGEDFLGTKE 896

  Fly   806 SHILLM-IITFGIFHLMERQTEFIAKVDYNWK---RQLIKKQEDALITNDTIKVLLTNILPTHVA 866
            :.:||| :....:|: ..:|.|:.|::|:.|:   ::.|.:.:|....|:.   :|.||||.|||
  Rat   897 ASLLLMAMFLLAVFY-HGQQLEYTARLDFLWRVQAKEEINEMKDLREHNEN---MLRNILPGHVA 957

  Fly   867 DFYLSNQLQN-ELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKY 920
            ..:|.....| |||.:.||.|.||||||..|       :.:..|   ||:|||||.|||::|.:
  Rat   958 RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGE- 1021

  Fly   921 SQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRV 985
            .:...:||||....||||..||         :|
  Rat  1022 DRFQDIEKIKTIGSTYMAVSGL---------SP-------------------------------- 1045

  Fly   986 PYGNGSNIALDLDLERGQYE---GNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNT 1047
                          |:.|.|   |::.                    .:|:|:|.|..:::..|.
  Rat  1046 --------------EKQQCEDKWGHLC--------------------ALADFSLALTESIQEINK 1076

  Fly  1048 ENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENT 1112
            .:. ..:|       ||||||||..:|||:|..||.|||||..||:|||||||||.|:|||.|.|
  Rat  1077 HSF-NNFE-------LRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEET 1133

  Fly  1113 ALKLREFNIQCNYRGMTFVKG----RGNIPTYII 1142
            .|.|::.....:|||..:|||    .|.|.||.:
  Rat  1134 YLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	59/252 (23%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	99/181 (55%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	93/280 (33%)
Adcy8	NP_058838.1	Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000269|PubMed:16258073, ECO:0000269|PubMed:22494970, ECO:0000269|PubMed:22976297	1..179		9/37 (24%)
		Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000269|PubMed:22976297	1..106
		Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	38..40
		Essential for CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	49..51
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..117
		AcyC	211..564	CDD:441717	139/392 (35%)
		Guanylate_cyc	402..586	CDD:425528	100/184 (54%)
		Adcy_cons_dom	614..709	CDD:461877	21/107 (20%)
		Guanylate_cyc	970..1169	CDD:425528	93/282 (33%)
		Involved in CALM1 interaction. /evidence=ECO:0000269|PubMed:16258073	1106..1248		33/62 (53%)
		Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000269|PubMed:19305019	1197..1212
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1220..1248