DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and Adcy10

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_766617.2	Gene:	Adcy10 / 271639	MGIID:	2660854	Length:	1614	Species:	Mus musculus

Alignment Length:	888	Identity:	177/888 - (19%)
Similarity:	292/888 - (32%)	Gaps:	281/888 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 NLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIER 285
            |.|.:...|..|..|.   |..::||.|.:|.:....|.|..|..:.|..|.            .
Mouse   247 NFLRLACMLESDPELE---LSLQKYVMEIILKQIDDKQLRGYLSELRPVTIV------------F 296

  Fly   286 SKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVE 350
            .....::|.:|::..||                          :.|..|   |:|:.|.|.:  .
Mouse   297 VNLMFKEQDKVEVIGSA--------------------------IQAACV---HITSVLKVFR--G 330

  Fly   351 ALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNA----DHAKCCVDLGLRMIKDIRDVRE 411
            .::.:|: ||             .|..:.||.|.....|    .||       |....||.|...
Mouse   331 QINKVFM-FD-------------KGCSFLCVFGFPGEKAPDEITHA-------LESAVDIFDFCS 374

  Fly   412 KRHLNIDMRIGVHSGDVLSGVIG-AAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGE 475
            :.|....:.|||.||.|..|::| ..:.::.:..:.|:||.|: .....|.|.....|   .||.
Mouse   375 QVHKIRTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNIAARM-MMYYPGIVSCDSVT---YDGS 435

  Fly   476 ----YFFEDGTEK-----AREDPVLQKHGIR-------TFLIKSLRAPMHDPRRRMRERQVKKLS 524
                |||::..:|     |...||.|..|:.       .:||.: |...:....|:||  :....
Mouse   436 NLPAYFFKELPKKVMKGVADPGPVYQCLGLNEKVMFGMAYLICN-RYEGYPLLGRVRE--IDYFM 497

  Fly   525 EASKANFMHN-STLHQYNQVRNQAKLEMCRELDKMPIGR-------IQLTKVF------------ 569
            ...|...|.| |.:..|..:....|.::..|::.:....       |.|||:.
Mouse   498 STMKDFLMTNCSRVLMYEGLPGYGKSQVLMEIEYLASQHENHRAVAIALTKISFHQNFYTIQILM 562

  Fly   570 -------------RRSTRLTQDEIE---EETFRRNISSCCLFFRIRNWEFQYIKEPDVMLKYSIA 618
                         .|.|.| |:.::   :|.|.      ||...|.:.:|...:|...|.|
Mouse   563 ANVLGLDTCKHYKERQTNL-QNRVKTLLDEKFH------CLLNDIFHVQFPVSREMSRMSK---- 616

  Fly   619 LAWVIYMGLLTIQLLSKDARY--------HYWYIDGTTIILLTMLL------IV----------- 658
            :.....:..|.:::|::..|.        ...::|||:...:..|:      ||
Mouse   617 IRKQKQLEALFMKILAQTVREERIIFIIDEAQFVDGTSWAFIEKLIRSMPIFIVMSLAPFSEVPC 681

  Fly   659 -----------SWYKKLWIMYMS--------DADVSSPNGRLSGFLFRMS-------DEMQRNVV 697
                       :.|..|..|...        |..|||....|..:|...|       :|:.:|:.
Mouse   682 AAANAIMKNRNTTYITLGTMQPQEIRDKVCVDLSVSSIPRELDSYLVEGSCGIPYYCEELLKNLD 746

  Fly   698 IRVVMYF--------------------------LIIFSYCAVAIMQVVGCSSDEDYADLDPTYD- 735
            ...|:.|                          :.:|:..:....:|....|.....:|.|...
Mouse   747 HHRVLLFQQAETEQKTNVTWNNMFKHSVRPTDDMQLFTSISEGQKEVCYLVSGVRLNNLSPPASL 811

  Fly   736 --------ERVQCFHPWILTNCMTLVIGMSFLFTRIPFIIKSCFSALIMI-GYAVLVVSE-FNFI 790
                    :.:...|. :|..| ..:||::|. |.:.|.|..|::..:|| ..|.||.|. ||..
Mouse   812 KEISLVQLDSMSLSHQ-MLVRC-AAIIGLTFT-TELLFEILPCWNMKMMIKALATLVESNVFNCF 873

  Fly   791 YANSP-----STNV-NFNAKYSHILLMI---ITFG-IFHLMERQTEFIAKVDYNWKRQLIKKQED 845
            .::..     ..|| .|...|..:.|.:   :|:| ...|.|.:.|.:......:.|.:::|...
Mouse   874 RSSKDLQLALKQNVPTFEVHYRSLALKLKEGLTYGEEEELREMEGEVVECRILRFCRPIMQKTAY 938

  Fly   846 ALITNDTIKVL-------------------LTNILPTH--VADFYLSNQLQNELYYEEYDNVAVM 889
            .|...|..|||                   ..:.:|.|  :.|..|     |.|   :.|.|..|
Mouse   939 ELWLKDQKKVLHLKCARFLEESAHRCNHCRNVDFIPYHHFIVDIRL-----NTL---DMDTVKRM 995

  Fly   890 FASIKNFDTDKIGLRVLNEIICDFDDVLNKYS--QSLRVEKIK 930
            ..| :.|..|:      .|.|....::..||.  ::|.:.:|:
Mouse   996 VTS-QGFKIDE------EEAIFSKSELPRKYKFPENLSITEIR 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	15/62 (24%)
		CYCc	254..476	CDD:214485	47/230 (20%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	49/202 (24%)
		CYCc	856..1117	CDD:214485	19/98 (19%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	13/55 (24%)
Adcy10	NP_766617.2	CHD	40..214	CDD:143636
		CHD	292..461	CDD:143636	50/236 (21%)
		COG3899	485..>959	CDD:226415	90/489 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900