DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and Gucy2c

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_037302.1	Gene:	Gucy2c / 25711	RGDID:	2771	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	712	Identity:	154/712 - (21%)
Similarity:	245/712 - (34%)	Gaps:	245/712 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   510 DPRRR---MRERQVKKLSEASKANFMHNSTLHQYNQVRNQAKLEMCR-------ELDKMPIGRIQ 564
            |.|||   .|.||.|    ..|...:.....|.......:.|:|:.:       .|.|. .|.::
  Rat   492 DDRRRDTIQRVRQCK----YDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKF-YGTVK 551

  Fly   565 L-TKVF-------RRSTR-LTQDEIE--EETFRRNISSCCLFFRIRNWEFQYIKEPDVMLKYSIA 618
            | |::|       |.|.| :..|.|.  :.||             .:|||:.....|:....|
  Rat   552 LDTRIFGVVEYCERGSLREVLNDTISYPDGTF-------------MDWEFKISVLNDIAKGMS-- 601

  Fly   619 LAWVIYMGLLTIQLLSKDARYHYWYIDGTTIILLTML---LIVSWYKKLWIM--YMSDADVSSPN 678
                 |:....|::..: .:.....:|...::.:|..   .|:...|.||..  ::..|.:|.
  Rat   602 -----YLHSSKIEVHGR-LKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQ-- 658

  Fly   679 GRLSGFLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGC-SSDEDYADLDPTYDERVQCFH 742
               .|.::..|...|..::.:...|.|              .| ..:|....::.:|..:.  |.
  Rat   659 ---KGDVYSFSIIAQEIILRKETFYTL--------------SCRDQNEKIFRVENSYGTKP--FR 704

  Fly   743 PWILTNCMTLVIGMSFLFT------RIPFIIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNF 801
            |.:            ||.|      .:..::|||                    :...|....:|
  Rat   705 PDL------------FLETADEKELEVYLLVKSC--------------------WEEDPEKRPDF 737

  Fly   802 NAKYSHILLMIITFGIFH----------------LMERQTEFIAKVDYNWKRQLIKKQEDALITN 850
            . |....|..|  ||:||                |..|..|.:.:.    :.||.|.:.|..
  Rat   738 K-KIESTLAKI--FGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEE----RTQLYKAERDRA--- 792

  Fly   851 DTIKVLLTNILPTHVADFYLSNQLQNELYYEE---YDNVAVMFASIKNFDTDKIGLRVLNEIICD 912
            |.:..:|   ||..|........:.....|||   |.:..|.|.:|..:.|....:.:||:|...
  Rat   793 DHLNFML---LPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKS 854

  Fly   913 FDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSS 977
            ||.:::.:.    |.|::.....|:.|.||
  Rat   855 FDQIVDHHD----VYKVETIGDAYVVASGL----------------------------------- 880

  Fly   978 NADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTM 1042
                    |..||:..|:|:                                  ::.|||::..|
  Rat   881 --------PMRNGNRHAVDI----------------------------------SKMALDILSFM 903

  Fly  1043 RRFNTENMQTEYEGSTDYGM---LRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPG 1104
            ..|..|::.         |:   :|||:..|...||||||..|.|.::|:.||.||||:|||:|.
  Rat   904 GTFELEHLP---------GLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPL 959

  Fly  1105 QIQVTENTALKLREFNIQCNY--RGMTFVKGRGNIPTY-IIGI-DSEYQFLPHRPAAPTKED 1162
            :|.::.:|...||..:.|..|  ||.|::||||...|| :.|: |.||..    |..||.|:
  Rat   960 RIHMSSSTIAILRRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNL----PTPPTVEN 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831
		CYCc	254..476	CDD:214485
		Nucleotidyl_cyc_III	321..503	CDD:299850
		CYCc	856..1117	CDD:214485	60/266 (23%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	69/272 (25%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141
		PKc_like	479..749	CDD:304357	61/338 (18%)
		STYKc	501..744	CDD:214568	55/322 (17%)
		CYCc	787..978	CDD:214485	64/286 (22%)
		Guanylate_cyc	814..1001	CDD:278633	69/276 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900