DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and Gucy2g

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_620611.2	Gene:	Gucy2g / 245708	RGDID:	621853	Length:	1103	Species:	Rattus norvegicus

Alignment Length:	1326	Identity:	242/1326 - (18%)
Similarity:	417/1326 - (31%)	Gaps:	501/1326 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YNRSNPISLARTSSQAQTVQNEKN----------WEWSYLVRKCRNLELEDSYDLYMRRLRVGYL 65
            :|.|:|.|:.|..:..|...::.|          ||::|....|...|...::...::|..:..|
  Rat    57 WNISHPFSVQRLGAGLQIAVDKLNSEPVGPGNLSWEFTYTNATCNAKESLAAFIDQVQREHISVL 121

  Fly    66 ---------------------SLFIFIHVAVTVIH------TLLLLTTP--EIKYVYVDMVAYMC 101
                                 .||.|:. .:|.:.      |.:.|..|  ||..|..:.:.|:.
  Rat   122 IGPACPEAAEVIGLLASEWDIPLFDFVG-QMTALEDHFWCDTCVTLVPPKQEIGTVLRESLQYLG 185

  Fly   102 SGLVIWVVLGVNFRSELVSKHGWVVYATSWLAV--CVMVLMDIGLNVYHATSHNDILNPIYDAYT 164
                 |..:||...|...|  .|......|.||  .:.:...|...|.:::.|:|:|.....:.:
  Rat   186 -----WEYIGVFGGSSAGS--SWGEVNELWKAVEDELQLHFTITARVRYSSGHSDLLQEGLRSMS 243

  Fly   165 LYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAIYLSCVNLLGIFFRL 229
            ..|..:                :..|...:...::.|.:|..::|  .|.::|....|...|:
  Rat   244 SVARVI----------------ILICSSEDAKHILQAAEDLGLNS--REFVFLLLQQLEDSFW-- 288

  Fly   230 MRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQS 294
                         ::.:.|:.:.|:.:..|...|  |.|:.......:|     :..||.:|:
  Rat   289 -------------KEVLAEDKVTRFPKVYESVFL--IAPSTYGGSAGDD-----DFRKQVYQR-- 331

  Fly   295 QVDLRRSADSQTLKRWRQPDHGTLFIEPH----EDVTVLYADVVNYTHLTTTLDVKKLVEALHDL 355
               |||.....::....|       :.|:    .|..:|||..           |:::::|..|
  Rat   332 ---LRRPPFQSSISSEDQ-------VSPYSAYLHDALLLYAQT-----------VEEMMKAEKD- 374

  Fly   356 FVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMR 420
               |....:..:.||..     ...:.|:..|                 .:.|.:.|||::..:.
  Rat   375 ---FRDGRQLISTLRAD-----QVTLQGITGP-----------------VLLDAQGKRHMDYSVY 414

  Fly   421 IGVHSG-----------DVLSGVIGAAKWQFDI-----------WSKDV----DIANRLEATGA- 458
            ....||           |....||  ..|:.|:           :..|.    |:......|||
  Rat   415 ALQKSGNGSRFLPFLHYDSFQKVI--RPWRDDLNASGPHGSHPEYKPDCGFHEDLCRTKPPTGAG 477

  Fly   459 -TGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLIKSLRA---------------- 506
             |..|.....|::||                .|.....|...::..||.
  Rat   478 MTASVTAVIPTVTLL----------------VVASAAAITGLMLWRLRGKVQNHPGDTWWQIHYD 526

  Fly   507 -----PMHDPRRRMRERQVKKLSEASKANFMHNSTLHQYNQVRNQAKLEMCRELDKMPIGRIQLT 566
                 |.|.|..|.        :..|:.|..:.||:.......:.||.....||...|:|..|..
  Rat   527 SITLLPQHKPSHRG--------TPMSRCNVSNASTVKISADCGSFAKTHQDEELFYAPVGLYQGN 583

  Fly   567 KV------------FRRSTRLTQDEIEEETFRRNI----------------SSCC----LFFRIR 599
            .|            .::.|.|.:..:..|....||                :.||    |...:|
  Rat   584 HVALCYIGEEAEARIKKPTVLREVWLMCELKHENIVPFFGVCTEPPNICIVTQCCKKGSLKDVLR 648

  Fly   600 N------WEFQYIKEPDVM----------------LKYSIALA-------------WVIYMGLLT 629
            |      |.|:.....|::                ||.|..|.             |....| .|
  Rat   649 NSDHEMDWIFKLSFVYDIVNGMLFLHGSPLRSHGNLKPSNCLVDSHMQLKLAGFGLWEFKHG-ST 712

  Fly   630 IQLLSKDARYH---YWYIDGTTIILLTMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDE 691
            .::.:::|..|   ||     |...|..|..:.|             ..:|.|.:..|
  Rat   713 CRIYNQEATDHSELYW-----TAPELLRLRELPW-------------SGTPQGDVYSF------- 752

  Fly   692 MQRNVVIRVVMYFLIIFSYCAVAIMQVVGCSSDEDYADLDPTYDERVQCFHPWILTNCMTLVIGM 756
                                |:.:..::...:...:.||:...:|.:.|    |..:...:.:..
  Rat   753 --------------------AILLRDLIHQQAHGPFEDLEAAPEEIISC----IKDSRAPVPLRP 793

  Fly   757 SFL----FTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNF------------NAKY 805
            |.|    ..||..::::|                    :|.||.....|            ..:.
  Rat   794 SLLEDKGDERIVALVRAC--------------------WAESPEQRPAFPSIKKTLREASPRGRV 838

  Fly   806 SHILLMIITFGIF--HL----MERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTH 864
            |.:..|:....::  ||    .||..:.:|:     ||::.|              ||:.:||:.
  Rat   839 SILDSMMGKLEMYASHLEEVVEERTCQLVAE-----KRKVEK--------------LLSTMLPSF 884

  Fly   865 VADFYLSNQLQNELYYEEYDNVAVMFASIKNFDTDKIGL-------RVLNEIICDFDDVLNKYSQ 922
            |.:..::.:   .:..|.:::|.:.|:.|..| |....|       ::||::...||..:    |
  Rat   885 VGEQLIAGK---SVEPEHFESVTIFFSDIVGF-TKLCSLSSPLQVVKLLNDLYSLFDHTI----Q 941

  Fly   923 SLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPY 987
            :..|.|::.....||.|.||                                           |.
  Rat   942 THDVYKVETIGDAYMVASGL-------------------------------------------PI 963

  Fly   988 GNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQT 1052
            .||:..|.::                                  |..:|.|:.....|...:|..
  Rat   964 RNGAQHADEI----------------------------------ATMSLHLLSVTTNFQIGHMPE 994

  Fly  1053 EYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTA---L 1114
            |..      .||||:..|..:||||||:.|.|.::|:.|||||||:|:.:|.:|.|:::||   |
  Rat   995 ERL------KLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTARALL 1053

  Fly  1115 KLREFNIQCNYRGMTFVKGRGNIPTY 1140
            ....:::|  .||...|||:|...|:
  Rat  1054 VAGGYHLQ--KRGTISVKGKGEQTTF 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	45/272 (17%)
		CYCc	254..476	CDD:214485	46/253 (18%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	36/213 (17%)
		CYCc	856..1117	CDD:214485	62/270 (23%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	65/273 (24%)
Gucy2g	NP_620611.2	PBP1_GC_G_like	50..439	CDD:107367	84/480 (18%)
		ANF_receptor	66..417	CDD:279440	75/447 (17%)
		PK_GC	558..832	CDD:270894	54/343 (16%)
		CYCc	868..1058	CDD:214485	66/299 (22%)
		Guanylate_cyc	895..1081	CDD:278633	65/273 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810