DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and Phlpp2

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001116066.2	Gene:	Phlpp2 / 244650	MGIID:	2444928	Length:	1355	Species:	Mus musculus

Alignment Length:	368	Identity:	68/368 - (18%)
Similarity:	117/368 - (31%)	Gaps:	123/368 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 LSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQT----------LKRWRQPDHGTL 318
            :.|||.         |..:||..|:  :|.|.......|.:||          .:||::.
Mouse   226 MHILPL---------VGGKIEEVKR--RQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQ----- 274

  Fly   319 FIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIA--SEEYNVLRIKFLG--DCYY 379
                       .:.||:....|..|....|.|....||...||.  :..:|.::::..|  |..:
Mouse   275 -----------ASKVVSQRMSTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLH 328

  Fly   380 CVAGLANPNADHAK--------CCV--------------DL------------------GLRMIK 404
            ..:.|...|..|.|        |.:              ||                  ||..:.
Mouse   329 KFSQLKGLNLSHNKLGLFPVLLCEISTLTELSLSCNGFHDLPSQIGKLLNLQTLSLDGNGLTALP 393

  Fly   405 D-IRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKT 468
            | :.::|:...|.|......|..:||.        :..:..|.....||||.........:||
Mouse   394 DELGNLRQLTSLGISFNDFRHIPEVLE--------KLTMLDKVAMAGNRLEVLNLGALTRMSQ-- 448

  Fly   469 LSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMH 533
            :..:|                 |:.:.::|.:.:::....|.....:|:.|:..|..:|..
Mouse   449 VKHVD-----------------LRMNHLKTVITENMEGNKHITHMDLRDNQLTDLDLSSLC---- 492

  Fly   534 NSTLHQYNQVRNQAKLEMCRELDKMPIGRIQLTKVFRRSTRLT 576
              :|.|.:..|||        |.::.:....|..::....|||
Mouse   493 --SLEQLHCERNQ--------LRELTLSGFSLRTLYASWNRLT 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	4/19 (21%)
		CYCc	254..476	CDD:214485	51/266 (19%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	39/226 (17%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
Phlpp2	NP_001116066.2	PH_PHLPP-like	181..275	CDD:270131	14/75 (19%)
		leucine-rich repeat	285..305	CDD:275380	6/19 (32%)
		leucine-rich repeat	306..332	CDD:275380	4/25 (16%)
		LRR_RI	309..548	CDD:238064	44/258 (17%)
		LRR_8	354..412	CDD:290566	8/57 (14%)
		leucine-rich repeat	356..378	CDD:275380	2/21 (10%)
		leucine-rich repeat	379..401	CDD:275380	3/21 (14%)
		leucine-rich repeat	402..424	CDD:275380	5/29 (17%)
		LRR_8	425..483	CDD:290566	12/76 (16%)
		leucine-rich repeat	425..448	CDD:275380	5/22 (23%)
		LRR_RI	447..714	CDD:238064	20/112 (18%)
		leucine-rich repeat	449..472	CDD:275380	3/39 (8%)
		leucine-rich repeat	474..493	CDD:275380	4/24 (17%)
		leucine-rich repeat	494..513	CDD:275380	6/26 (23%)
		leucine-rich repeat	514..535	CDD:275380	4/12 (33%)
		LRR_8	536..592	CDD:290566
		leucine-rich repeat	536..558	CDD:275380
		leucine-rich repeat	559..581	CDD:275380
		leucine-rich repeat	582..597	CDD:275380
		LRR_8	604..664	CDD:290566
		leucine-rich repeat	604..627	CDD:275380
		leucine-rich repeat	628..653	CDD:275380
		leucine-rich repeat	654..677	CDD:275380
		LRR_8	676..735	CDD:290566
		leucine-rich repeat	678..701	CDD:275380
		leucine-rich repeat	702..724	CDD:275380
		leucine-rich repeat	747..768	CDD:275380
		PP2Cc	816..1065	CDD:238083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900