DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACXD and Gucy1b2

DIOPT Version :10

Sequence 1:NP_620469.2 Gene:ACXD / 38284 FlyBaseID:FBgn0040507 Length:1162 Species:Drosophila melanogaster
Sequence 2:XP_011243363.2 Gene:Gucy1b2 / 239134 MGIID:2660873 Length:829 Species:Mus musculus


Alignment Length:432 Identity:92/432 - (21%)
Similarity:175/432 - (40%) Gaps:116/432 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   177 LLQPFVLGSAVTFCYIINYSFVITAKDDNQMHS--------ILNEAIYLSCVNLLGIFF---RL- 229
            ::.|.|..:..:.|..||..|::..:.:....:        :..:.|::..:..: :|.   :| 
Mouse   425 IVHPQVTFNISSICKFINSQFILKTRREMMPEAWKSQPTLKLRGQMIWMESLKCM-VFMCSPKLR 488

  Fly   230 -----------MRDIALRTT-----FLDRRQYVEENLLLRYARDQE----------------RSL 262
                       :.|||...|     .|::::..|..|..:..:.:|                .:|
Mouse   489 SLQELEESKMHLSDIAPHDTTRDLILLNQQRLAEMELSCQLEKKKEELRVLSNHLAIEKKKTETL 553

  Fly   263 LLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVT 327
            |.::||..:|::|:|..|                                     :.....|..|
Mouse   554 LYAMLPEHVANQLKEGKK-------------------------------------VAAGEFETCT 581

  Fly   328 VLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHA 392
            :|::|||.:|::....:..::|..|:.::.:||..:..::|.:::.:||.|..|.|:..|...||
Mouse   582 ILFSDVVTFTNICAACEPIQIVNMLNSMYSKFDRLTNIHDVYKVETIGDAYMVVGGVPVPVESHA 646

  Fly   393 KCCVD--LGLRMIKDIRDVREKRHLN------IDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDI 449
            :...:  ||:|       :..|..:|      |.:|:|:|:|.||:||:|....::.::...|:.
Mouse   647 QRVANFALGMR-------ISAKEVMNPVTGEPIQIRVGIHTGPVLAGVVGDKMPRYCLFGDTVNT 704

  Fly   450 ANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRT-FLIKSLRA------- 506
            |:|:|:.|...:||:|......|:.: .||..|.  .|..|..|..:.| |||::|.|       
Mouse   705 ASRMESHGLPNKVHLSPTAHRALENK-GFEIVTR--GEIEVKGKGKMTTYFLIRNLNATEVEIMG 766

  Fly   507 ---PMHDPRRRMRERQVKKLSEASKANFMHNSTLHQYNQVRN 545
               .:.|.:.....|...|...|..:|..|    || .||.|
Mouse   767 RPSALADGKEASTPRNQVKKPRAVLSNMDH----HQ-QQVYN 803

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXDNP_620469.2 AC_N <42..284 CDD:318454 25/150 (17%)
Nucleotidyl_cyc_III 321..503 CDD:448371 54/190 (28%)
Nucleotidyl_cyc_III 878..1142 CDD:448371
Gucy1b2XP_011243363.2 HNOB 115..276 CDD:462233
HNOBA 380..566 CDD:462234 22/141 (16%)
Guanylate_cyc 572..754 CDD:425528 52/191 (27%)
Blue background indicates that the domain is not in the aligned region.

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