DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and PHLPP1

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_919431.2	Gene:	PHLPP1 / 23239	HGNCID:	20610	Length:	1717	Species:	Homo sapiens

Alignment Length:	60	Identity:	21/60 - (35%)
Similarity:	30/60 - (50%)	Gaps:	5/60 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   966 GRRSRYDGARSSNADGVQRVP-YGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSS 1024
            |||.| .||....|.|...|| .|.|:|..|   |.||:.:.|:..:....||:.:.|::
Human    91 GRRRR-RGAPQPIAGGAAPVPGAGGGANSLL---LRRGRLKRNLSAAAAAASSSSSSSAA 146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831
		CYCc	254..476	CDD:214485
		Nucleotidyl_cyc_III	321..503	CDD:299850
		CYCc	856..1117	CDD:214485	21/60 (35%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	21/60 (35%)
PHLPP1	NP_919431.2	leucine-rich repeat	1107..1129	CDD:275380
		PP2Cc	1168..1420	CDD:214625
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1458..1510
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1673..1717
		PDZ-binding, required for interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1715..1717
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..118		12/27 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	136..156		3/11 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..470
		PH_PHLPP-like	535..631	CDD:270131
		PH	555..636	CDD:278594
		LRR_RI	625..929	CDD:238064
		LRR_8	638..703	CDD:290566
		LRR 1	638..659
		leucine-rich repeat	641..661	CDD:275380
		LRR 2	661..682
		leucine-rich repeat	662..692	CDD:275380
		LRR 3	692..712
		leucine-rich repeat	693..738	CDD:275380
		LRR_8	714..770	CDD:290566
		LRR 4	715..736
		LRR 5	738..760
		leucine-rich repeat	739..761	CDD:275380
		LRR 6	761..783
		leucine-rich repeat	762..784	CDD:275380
		LRR 7	784..804
		leucine-rich repeat	785..808	CDD:275380
		LRR 8	808..831
		leucine-rich repeat	810..832	CDD:275380
		LRR_RI	814..1074	CDD:238064
		LRR 9	832..853
		leucine-rich repeat	833..853	CDD:275380
		leucine-rich repeat	854..895	CDD:275380
		LRR 10	873..894
		LRR 11	895..916
		leucine-rich repeat	896..918	CDD:275380
		LRR 12	918..939
		leucine-rich repeat	919..941	CDD:275380
		LRR 13	941..962
		leucine-rich repeat	942..963	CDD:275380
		LRR_8	962..1024	CDD:290566
		LRR 14	963..984
		leucine-rich repeat	964..987	CDD:275380
		LRR 15	987..1008
		leucine-rich repeat	988..1011	CDD:275380
		LRR 16	1013..1033
		LRR_8	1014..1072	CDD:290566
		leucine-rich repeat	1014..1037	CDD:275380
		LRR 17	1037..1058
		leucine-rich repeat	1038..1061	CDD:275380
		LRR 18	1061..1082
		Interaction with SLC9A3R1. /evidence=ECO:0000269\|PubMed:21804599	1076..1205
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900