DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and PHLPP2

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_055835.2	Gene:	PHLPP2 / 23035	HGNCID:	29149	Length:	1323	Species:	Homo sapiens

Alignment Length:	392	Identity:	80/392 - (20%)
Similarity:	144/392 - (36%)	Gaps:	97/392 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 LSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQT----------LKRWRQPDHGTL 318
            :.|||.         |..:||..|:  :|.|.......|.:||          .:||::.
Human   194 MHILPL---------VGGKIEEVKR--RQYSLAFSSAGAQAQTYHVSFETLAEYQRWQRQ----- 242

  Fly   319 FIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIA--SEEYNVLRIKFLG--DCYY 379
                       .:.||:....|..|....|.|....||...||.  :..:|.::::..|  |..|
Human   243 -----------ASKVVSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLY 296

  Fly   380 CVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHS-----GDVLSGVIGAAKWQ 439
            ..:.|...|..|.|    |||..|. :.::.....||:... |.|.     |::|:.........
Human   297 KFSQLKGLNLSHNK----LGLFPIL-LCEISTLTELNLSCN-GFHDLPSQIGNLLNLQTLCLDGN 355

  Fly   440 FDIWSKDVDIAN--RLEATGAT----GRVHVSQKTLSLLDGEYFFEDGTEKA------REDPV-- 490
            | :.:...::.|  :|.:.|.:    .::....:.|::||......:..|..      |.:.:
Human   356 F-LTTLPEELGNLQQLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKH 419

  Fly   491 --LQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTLHQYNQVRNQAKLEMCR 553
              |:.:.::|.:|::|....|.....:|:.::..|..:|..      :|.|.:..|||
Human   420 VDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLC------SLEQLHCGRNQ------- 471

  Fly   554 ELDKMPIGRIQLTKVFRRSTRLTQDEIEEE----TF---RRNISSCCLFFRIRNW--EFQYIKEP 609
             |.::.:....|..::..|.|||...:...    ||   .||:..|     :.:|  |.:.|:..
Human   472 -LRELTLSGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLEC-----VPDWACEAKKIEVL 530

  Fly   610 DV 611
            ||
Human   531 DV 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	4/19 (21%)
		CYCc	254..476	CDD:214485	49/236 (21%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	40/206 (19%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
PHLPP2	NP_055835.2	PH_PHLPP-like	149..243	CDD:270131	14/75 (19%)
		LRR 1	250..271		6/20 (30%)
		leucine-rich repeat	253..273	CDD:275380	6/19 (32%)
		LRR 2	273..296		5/22 (23%)
		leucine-rich repeat	274..300	CDD:275380	5/25 (20%)
		LRR 3	300..321		8/25 (32%)
		leucine-rich repeat	301..323	CDD:275380	8/26 (31%)
		LRR_RI	313..606	CDD:238064	46/242 (19%)
		LRR_8	322..380	CDD:290566	10/59 (17%)
		LRR 4	323..344		5/21 (24%)
		leucine-rich repeat	324..346	CDD:275380	5/22 (23%)
		LRR 5	346..368		2/22 (9%)
		leucine-rich repeat	347..369	CDD:275380	2/22 (9%)
		LRR 6	369..390		2/20 (10%)
		leucine-rich repeat	370..416	CDD:275380	7/45 (16%)
		LRR 7	392..412		3/19 (16%)
		LRR 8	416..439		4/22 (18%)
		leucine-rich repeat	418..440	CDD:275380	4/21 (19%)
		LRR 9	440..460		4/19 (21%)
		leucine-rich repeat	442..461	CDD:275380	3/24 (13%)
		LRR 10	461..480		6/26 (23%)
		leucine-rich repeat	462..481	CDD:275380	6/26 (23%)
		LRR 11	481..502		5/20 (25%)
		leucine-rich repeat	482..503	CDD:275380	5/20 (25%)
		LRR 12	503..524		6/25 (24%)
		leucine-rich repeat	504..526	CDD:275380	7/26 (27%)
		LRR 13	526..547		3/7 (43%)
		leucine-rich repeat	527..549	CDD:275380	3/6 (50%)
		LRR_8	549..606	CDD:290566
		LRR 14	549..570
		leucine-rich repeat	550..565	CDD:275380
		LRR 15	571..592
		leucine-rich repeat	572..595	CDD:275380
		LRR 16	595..616
		leucine-rich repeat	596..645	CDD:275380
		LRR 17	621..644
		LRR_8	645..703	CDD:290566
		LRR_4	645..685	CDD:289563
		LRR 18	645..666
		leucine-rich repeat	646..669	CDD:275380
		LRR 19	669..690
		leucine-rich repeat	670..692	CDD:275380
		LRR 20	692..713
		leucine-rich repeat	693..714	CDD:275380
		LRR 21	714..735
		leucine-rich repeat	715..734	CDD:275380
		LRR 22	737..758
		leucine-rich repeat	738..764	CDD:275380
		PP2Cc	784..1033	CDD:238083
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1285..1323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900