Protein Alignment ACXD and Adcy5

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001012783.3
• Gene: Adcy5 / 224129
• MGIID: 99673
• Length: 1262
• Species: Mus musculus
• Alignment Length: 1188
• Identity: 328/1188 - (27%)
• Similarity: 544/1188 - (45%)
• Gaps: 251/1188 - (21%)

  Fly    48 ELEDSYDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSGLVIWVVLGV 112
            :||..|..|..||....|::.:.:.|.|.::........|.::..|:.::|.....::|..|| .
Mouse   226 KLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQIAYLAVLAAAVGVILIMAVL-C 289

  Fly   113 NFRSELVSKH-GWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPY 176
            | |:.....| |...||   |...|:.:..:||.:....|.::.:  .:..:.:|.||..:||
Mouse   290 N-RAAFHQDHMGLACYA---LIAVVLAVQVVGLLLPQPRSASEGI--WWTVFFIYTIYTLLPV-- 346

  Fly   177 LLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAIYLSCVNLLGIFFRLMRDIALRTTFLD 241
            .::..||...:.....:..|....::|...:..:::..:..||.|::|:......:::.|..|.:
Mouse   347 RMRAAVLSGVLLSALHLAISLHTNSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQE 411

  Fly   242 RRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQT 306
            .|:.::..|..:....|:..||||:||..:|..::.|:     .:||:.....::
Mouse   412 TRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADI-----NAKQEDMMFHKI---------- 461

  Fly   307 LKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRI 371
                        :|:.|::|::|:||:..:|.|.:....::||..|::||.|||..:.|.:.|||
Mouse   462 ------------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI 514

  Fly   372 KFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAA 436
            |.||||||||:||....||||.|||::|:.||:.|..|||...:|::||:|:|||.|..||:|..
Mouse   515 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 579

  Fly   437 KWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLI 501
            |||||:||.||.:||.:||.|..||:|:::.||:.|:|:|..|.|....| :..|::|.|.||||
Mouse   580 KWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGDR-NAYLKEHSIETFLI 643

  Fly   502 KSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTLHQ------YNQV-RNQAKLEMCR------ 553
            .|.     ..:|:..:..:.|::.....:..||.. |.      ||.: .||...||.|
Mouse   644 LSC-----TQKRKEEKAMIAKMNRQRTNSIGHNPP-HWGAERPFYNHLGGNQVSKEMKRMGFEDP 702

  Fly   554 -------------ELDKMPIGRIQLTKVFRRSTRLTQDEIEEETFRRNISSCCLFFRIRNWEFQY 605
                         |:|:. :||    .:..||.    |.:..|..|:.:    |.||..:.|.:|
Mouse   703 KDKNAQESANPEDEVDEF-LGR----AIDARSI----DRLRSEHVRKFL----LTFREPDLEKKY 754

  Fly   606 IKEPDVMLKYSIALAWVIYMGLLTIQ---------LLSKDARYHYWYIDGTTIILLTMLLIVSWY 661
            .|:.|......:|.|.::::.:..:|         :||       :|:  :..:||.:::.||
Mouse   755 SKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLS-------FYL--SCFLLLALVVFVS-- 808

  Fly   662 KKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIF-SYCAVAIMQVVGCSSDE 725
                ::|.......:|...||..:.|.........|..:.:.||..| :........:|||.::|
Mouse   809 ----VIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMCNSKNLVGCLAEE 869

  Fly   726 DYADLDPTY--------------DERVQCFHPWILTNC-----MTLVIGMSFLFTRIPFIIKSCF 771
            ....::...              ||:..|..|  ..||     .|..:.:|.|...: |:..||.
Mouse   870 HNITVNQVNACHVMESAFNYSLGDEQGFCGSP--QPNCNFPEYFTYSVLLSLLACSV-FLQISCI 931

  Fly   772 SALIMI-----GYAVLV----VSEFN----FIYANSPSTNVNFNAK----YSHILLMIIT---FG 816
            ..|:::     .|.::|    |:.|:    .:.||:...:.|..::    .:.:.|.::|   ..
Mouse   932 GKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIIS 996

  Fly   817 IF----HLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQN- 876
            :|    :|..:|.|..|::|:.||.|..:::|:........:.||.||||..||..:|:.:.:|
Mouse   997 VFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRND 1061

  Fly   877 ELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKYSQSLRVEKIKV 931
            ||||:..:.||||||||.||       :.:..|   ||:|||||.|||::::: .:..::||||.
Mouse  1062 ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE-DRFRQLEKIKT 1125

  Fly   932 ANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALD 996
            ...|||||.||:                        .|.||.|
Mouse  1126 IGSTYMAASGLN------------------------DSTYDKA---------------------- 1144

  Fly   997 LDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYG 1061
                               ..||        ::.:|:||:.||..|:..|        |.|.:..
Mouse  1145 -------------------GKTH--------IKAIADFAMKLMDQMKYIN--------EHSFNNF 1174

  Fly  1062 MLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTEN--TALKLREFNIQCN 1124
            .::||::.|..:|||:|..||.||||||.||:||||||||||.:||||.:  ..|....:.::|
Mouse  1175 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC- 1238

  Fly  1125 YRGMTFVKGRGNIPTYII 1142
             ||:..|||:|.:.||.:
Mouse  1239 -RGVVKVKGKGEMMTYFL 1255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	52/236 (22%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	87/181 (48%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	91/275 (33%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:318454	54/246 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..194
		Guanylate_cyc	461..623	CDD:425528	78/183 (43%)
		Adcy_cons_dom	669..762	CDD:461877	26/106 (25%)
		Guanylate_cyc	1063..1257	CDD:425528	91/277 (33%)