DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and Adcy5

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001012783.3	Gene:	Adcy5 / 224129	MGIID:	99673	Length:	1262	Species:	Mus musculus

Alignment Length:	1188	Identity:	328/1188 - (27%)
Similarity:	544/1188 - (45%)	Gaps:	251/1188 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ELEDSYDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSGLVIWVVLGV 112
            :||..|..|..||....|::.:.:.|.|.::........|.::..|:.::|.....::|..|| .
Mouse   226 KLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQIAYLAVLAAAVGVILIMAVL-C 289

  Fly   113 NFRSELVSKH-GWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPY 176
            | |:.....| |...||   |...|:.:..:||.:....|.::.:  .:..:.:|.||..:||
Mouse   290 N-RAAFHQDHMGLACYA---LIAVVLAVQVVGLLLPQPRSASEGI--WWTVFFIYTIYTLLPV-- 346

  Fly   177 LLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEAIYLSCVNLLGIFFRLMRDIALRTTFLD 241
            .::..||...:.....:..|....::|...:..:::..:..||.|::|:......:::.|..|.:
Mouse   347 RMRAAVLSGVLLSALHLAISLHTNSQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQE 411

  Fly   242 RRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQT 306
            .|:.::..|..:....|:..||||:||..:|..::.|:     .:||:.....::
Mouse   412 TRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADI-----NAKQEDMMFHKI---------- 461

  Fly   307 LKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRI 371
                        :|:.|::|::|:||:..:|.|.:....::||..|::||.|||..:.|.:.|||
Mouse   462 ------------YIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRI 514

  Fly   372 KFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAA 436
            |.||||||||:||....||||.|||::|:.||:.|..|||...:|::||:|:|||.|..||:|..
Mouse   515 KILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 579

  Fly   437 KWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLI 501
            |||||:||.||.:||.:||.|..||:|:::.||:.|:|:|..|.|....| :..|::|.|.||||
Mouse   580 KWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGDR-NAYLKEHSIETFLI 643

  Fly   502 KSLRAPMHDPRRRMRERQVKKLSEASKANFMHNSTLHQ------YNQV-RNQAKLEMCR------ 553
            .|.     ..:|:..:..:.|::.....:..||.. |.      ||.: .||...||.|
Mouse   644 LSC-----TQKRKEEKAMIAKMNRQRTNSIGHNPP-HWGAERPFYNHLGGNQVSKEMKRMGFEDP 702

  Fly   554 -------------ELDKMPIGRIQLTKVFRRSTRLTQDEIEEETFRRNISSCCLFFRIRNWEFQY 605
                         |:|:. :||    .:..||.    |.:..|..|:.:    |.||..:.|.:|
Mouse   703 KDKNAQESANPEDEVDEF-LGR----AIDARSI----DRLRSEHVRKFL----LTFREPDLEKKY 754

  Fly   606 IKEPDVMLKYSIALAWVIYMGLLTIQ---------LLSKDARYHYWYIDGTTIILLTMLLIVSWY 661
            .|:.|......:|.|.::::.:..:|         :||       :|:  :..:||.:::.||
Mouse   755 SKQVDDRFGAYVACASLVFLFICFVQITIVPHSLFMLS-------FYL--SCFLLLALVVFVS-- 808

  Fly   662 KKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVMYFLIIF-SYCAVAIMQVVGCSSDE 725
                ::|.......:|...||..:.|.........|..:.:.||..| :........:|||.::|
Mouse   809 ----VIYACVKLFPTPLQTLSRKIVRSKKNSTLVGVFTITLVFLSAFVNMFMCNSKNLVGCLAEE 869

  Fly   726 DYADLDPTY--------------DERVQCFHPWILTNC-----MTLVIGMSFLFTRIPFIIKSCF 771
            ....::...              ||:..|..|  ..||     .|..:.:|.|...: |:..||.
Mouse   870 HNITVNQVNACHVMESAFNYSLGDEQGFCGSP--QPNCNFPEYFTYSVLLSLLACSV-FLQISCI 931

  Fly   772 SALIMI-----GYAVLV----VSEFN----FIYANSPSTNVNFNAK----YSHILLMIIT---FG 816
            ..|:::     .|.::|    |:.|:    .:.||:...:.|..::    .:.:.|.::|   ..
Mouse   932 GKLVLMLAIEFIYVLIVEVPGVTLFDNADLLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIIS 996

  Fly   817 IF----HLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQN- 876
            :|    :|..:|.|..|::|:.||.|..:::|:........:.||.||||..||..:|:.:.:|
Mouse   997 VFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRND 1061

  Fly   877 ELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKYSQSLRVEKIKV 931
            ||||:..:.||||||||.||       :.:..|   ||:|||||.|||::::: .:..::||||.
Mouse  1062 ELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE-DRFRQLEKIKT 1125

  Fly   932 ANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALD 996
            ...|||||.||:                        .|.||.|
Mouse  1126 IGSTYMAASGLN------------------------DSTYDKA---------------------- 1144

  Fly   997 LDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYG 1061
                               ..||        ::.:|:||:.||..|:..|        |.|.:..
Mouse  1145 -------------------GKTH--------IKAIADFAMKLMDQMKYIN--------EHSFNNF 1174

  Fly  1062 MLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTEN--TALKLREFNIQCN 1124
            .::||::.|..:|||:|..||.||||||.||:||||||||||.:||||.:  ..|....:.::|
Mouse  1175 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLEC- 1238

  Fly  1125 YRGMTFVKGRGNIPTYII 1142
             ||:..|||:|.:.||.:
Mouse  1239 -RGVVKVKGKGEMMTYFL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	52/236 (22%)
		CYCc	254..476	CDD:214485	88/221 (40%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	87/181 (48%)
		CYCc	856..1117	CDD:214485	93/273 (34%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	91/275 (33%)
Adcy5	NP_001012783.3	AC_N	1..459	CDD:292831	54/246 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..194
		CYCc	425..620	CDD:214485	88/221 (40%)
		Guanylate_cyc	461..622	CDD:278633	78/182 (43%)
		DUF1053	669..761	CDD:283888	26/105 (25%)
		CYCc	1037..1238	CDD:214485	93/282 (33%)
		Guanylate_cyc	1063..1257	CDD:278633	91/277 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910