Protein Alignment ACXD and ADCY4

DIOPT Version :9

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001185497.1
• Gene: ADCY4 / 196883
• HGNCID: 235
• Length: 1077
• Species: Homo sapiens
• Alignment Length: 1202
• Identity: 313/1202 - (26%)
• Similarity: 524/1202 - (43%)
• Gaps: 262/1202 - (21%)

  Fly    53 YDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVD---MVAYMCSGLVIWVVLGVNF 114
            |:.|. .|...|..|.:.:.:.:..:..||.:.....:.:..|   :...:|:.....::||:..
Human    17 YETYY-SLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLAS 80

  Fly   115 RSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYD--AYTLYAIYMFMPVPYL 177
            |.:.:.:....:....|:|     |:.:|    ||......:...:|  :|.|:.|:    ..|.
Human    81 REQRLQRWTRPLSGLVWVA-----LLALG----HAFLFTGGVVSAWDQVSYFLFVIF----TAYA 132

  Fly   178 LQPF------VLGSAVTFCYIINYSFVITAKDDNQ---MHSILNEAIYLSCVNLLGIFFRLMRDI 233
            :.|.      |.|.|.:..:::.....:..:.|::   :..:...|:...|.|:.|::.:.:.:.
Human   133 MLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMER 197

  Fly   234 ALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDL 298
            |||.||.:....:.....|...:..:..||||||||.:|..::.::..|::..:....:.:.
Human   198 ALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTN--- 259

  Fly   299 RRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIAS 363
                           :..:|:::.|:.|:|||||:|.:|.|.:....|:||..|::||.:||..:
Human   260 ---------------NFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIA 309

  Fly   364 EEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDV 428
            :|:..:|||.||||||||:||.....|||..||.:||.|.:.||.:|....::|:||:|||||.|
Human   310 KEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSV 374

  Fly   429 LSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQK 493
            |.||||..|||:|:||.||.:||.:||.|..||||::..||:||.|.|..||...:.| ||.|::
Human   375 LCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEHR-DPYLRE 438

  Fly   494 HGIRTFLIKSLRAPMHDPR------------RRMR-----ERQVKK------------------- 522
            .|..|:|:...||...|.:            .:||     .|.::.
Human   439 LGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKPFAHLSHGDSPVST 503

  Fly   523 ---LSEASKANFMHNSTLHQYNQVRNQAKLEMCRELDKMPIGRIQLTKVFRRSTRLTQDEIEEET 584
               |.|.:.|:|   ||....::.|....|:     |::..|.   .|.|:...:|...:..:::
Human   504 STPLPEKTLASF---STQWSLDRSRTPRGLD-----DELDTGD---AKFFQVIEQLNSQKQWKQS 557

  Fly   585 FRRNISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLLSKDARYHYWYIDGTTI 649
              ::.:...|:||.:..|.:|........||..|..:::::....||:|..:...........|.
Human   558 --KDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVTNRPPALAITYSITF 620

  Fly   650 ILLTMLLIVSWYKKL------------WIMYMSDADVSSPNGRLSGFLFRMSDEMQRNVVIRVVM 702
            :|..::|.|.:.:.|            |:..:|....:.|.                   :|:.:
Human   621 LLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPG-------------------LRIAL 666

  Fly   703 YFLIIFSYCAVAIMQVVGCSSDEDYADLDPTYDERVQCFHPWILTNCMTLVIGMSFLFTRIPFII 767
            ....|....|:||..:....:..|.....|.....:... .|.|...:.|:        .:|:.:
Human   667 GTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNL-SWELPGSLPLI--------SVPYSM 722

  Fly   768 KSCFSALIMIGYAVLVVSEFNFI-----YANSPSTNVNFNAKYSHILLM---------------- 811
            ..|....:.....:.:..|...:     .|.|.|..::.:|..|..|::
Human   723 HCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSRPGVLKE 787

  Fly   812 -----IITFGIFH----LMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVAD 867
                 .|:|.||.    ::.||.|:..::|:.||::|.:::|:.....:..::||.|:||.|||.
Human   788 PKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAP 852

  Fly   868 FYLSNQLQNE-LYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKYS 921
            .::....:|| ||::.|:.|.|:|||:.:|       :.:..|   ||:|||||.|||::|:|..
Human   853 QFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK 917

  Fly   922 QSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVP 986
            .| .|||||....|||||.||:.                               :|..|..|
Human   918 FS-GVEKIKTIGSTYMAATGLNA-------------------------------TSGQDAQQ--- 947

  Fly   987 YGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDL---MRTMRRFNTE 1048
                       |.||              |.:|.|:        |.|||:.|   :..:.:.:..
Human   948 -----------DAER--------------SCSHLGT--------MVEFAVALGSKLDVINKHSFN 979

  Fly  1049 NMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTA 1113
            |.:           ||:|::||..:|||:|..||.||||||.||:||||:||||.|:|||||.||
Human   980 NFR-----------LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETA 1033

  Fly  1114 LKLREFNIQCNYRGMTFVKGRGNIPTYIIGID 1145
            ..|:.....|..||:..|||:|.:.||.:..|
Human  1034 WALQSLGYTCYSRGVIKVKGKGQLCTYFLNTD 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	48/244 (20%)
		CYCc	254..476	CDD:214485	90/221 (41%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	89/181 (49%)
		CYCc	856..1117	CDD:214485	95/274 (35%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	95/276 (34%)
ADCY4	NP_001185497.1	AC_N	<115..246	CDD:292831	29/134 (22%)
		CYCc	219..422	CDD:214485	90/220 (41%)
		Guanylate_cyc	264..418	CDD:278633	77/153 (50%)
		DUF1053	479..583	CDD:283888	19/116 (16%)
		CYCc	827..1042	CDD:214485	97/293 (33%)
		Guanylate_cyc	864..1063	CDD:278633	95/277 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D181177at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45627
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.880