DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and gcy-34

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_506319.1	Gene:	gcy-34 / 191656	WormBaseID:	WBGene00001554	Length:	686	Species:	Caenorhabditis elegans

Alignment Length:	368	Identity:	88/368 - (23%)
Similarity:	159/368 - (43%)	Gaps:	60/368 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 KDDNQMHSILNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYAR--DQERSLLL 264
            |....|.|.....||| |...:.....||: ..:|.|.:.......:.:||...|  |.|.:|.|
Worm   342 KGQMMMLSTKKHIIYL-CSPYVTSINELMQ-FGMRLTAMPLHDATRDLILLNQQRLSDVEVNLQL 404

  Fly   265 SILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHE-DVTV 328
            .....|:     |.:.:.:|..:|:.....:..|.|....|.|    ..:|    :||.| :.||
Worm   405 EANNEQL-----ETMTHELEVERQKTDSILKDMLPRKIAKQLL----SGEH----LEPCEYEATV 456

  Fly   329 LYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAK 393
            ::.|:..:..:......|.:|:.|:::|.:.|.......|.:::.:.|.|..|:|:.:..::||:
Worm   457 MFCDLPAFQQIIPVCQPKNIVKLLNEVFFKLDRIVVLRGVYKVETVSDSYMTVSGIPDYTSEHAE 521

  Fly   394 --CCVDLGL----RMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANR 452
              |.|.||:    |.:.|  .|.:...|   :|||:|||.:::||:|....::.::.:.|.:|::
Worm   522 NMCHVALGMMWEARSVMD--PVNKTPFL---LRIGLHSGTIIAGVVGTKMPRYCLFGETVTLASQ 581

  Fly   453 LEATGATGRVHVSQKTLS--LLDGEYFFEDG---TEKAREDPVLQKHGIRT-FLIKSLRA---PM 508
            :|:.|..|::..|..|.|  :..|.:.|...   ..|.|.|       :.| ||::||:.   .:
Worm   582 MESLGVAGKIQCSSWTYSKAMETGRFEFSPRGRINVKGRGD-------VETYFLMRSLKKSIWEI 639

  Fly   509 HDPRRRMRERQVKKLSEAS---------------KANFMHNST 536
            .|..|.:....::...|..               |||..|::|
Worm   640 TDHERDVNVNSIEGYEELEIFIENAQTVKHDGHPKANQNHSAT 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	20/83 (24%)
		CYCc	254..476	CDD:214485	58/232 (25%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	51/194 (26%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gcy-34	NP_506319.1	HNOB	3..167	CDD:285002
		HNOBA	224..441	CDD:285003	24/105 (23%)
		CYCc	421..609	CDD:214485	50/200 (25%)
		Guanylate_cyc	453..629	CDD:278633	47/187 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810