DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and gcy-23

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_500309.3	Gene:	gcy-23 / 191652	WormBaseID:	WBGene00001548	Length:	1073	Species:	Caenorhabditis elegans

Alignment Length:	340	Identity:	73/340 - (21%)
Similarity:	148/340 - (43%)	Gaps:	83/340 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 LYAIYMFM-PVPYLLQPFVLGSAVTFCYIINY------SFVITAKDDNQMHSILNEAIYLSCVN- 221
            :||..|.| .:.:...||..|:.|:  .:::|      :|..|..|..|:|..| .|:.|.|.|
Worm   728 IYAFGMVMHEILFRALPFPNGTNVS--EVMDYIRDGTKTFRPTVHDRTQIHPDL-VALLLDCWNE 789

  Fly   222 ------------------------LLGIFFRLMRDIA--LRTTFLDRRQYVEENLLLRYARDQER 260
                                    |:....|:|...|  |.....:|...:||      |..:..
Worm   790 NPEVRPSIRRVRLNTENYLKVKGSLVDQMMRMMEQYANNLEKLVAERTGMLEE------ANVRAD 848

  Fly   261 SLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHED 325
            .||..:||..:|:.|:                     :.||..::|.                :.
Worm   849 KLLGQLLPKYVANELK---------------------MGRSVPAKTF----------------DM 876

  Fly   326 VTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNA- 389
            .||:::|:|.:|.:.::....::|..|:.::.:||.|..::...:::.:||.|..|:|:...|.
Worm   877 ATVMFSDIVGFTTICSSSTPLEVVSMLNSIYSKFDDAINKHGSYKVETIGDAYMIVSGIPEENGN 941

  Fly   390 DHAK--CCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANR 452
            :|.:  |...|.|.::....::..:|::.:.:|:|:|:|.|.:||:|....::.::...|::|:|
Worm   942 EHIRNICNTALELMLLLKTYEIPHRRNVKLRIRLGIHTGTVAAGVVGLTAPRYCLFGDTVNVASR 1006

  Fly   453 LEATGATGRVHVSQK 467
            :|:|....::.:||:
Worm  1007 MESTSEPEKIQMSQE 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	34/152 (22%)
		CYCc	254..476	CDD:214485	46/217 (21%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	36/150 (24%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gcy-23	NP_500309.3	Periplasmic_Binding_Protein_Type_1	38..407	CDD:299141
		ANF_receptor	38..385	CDD:279440
		PK_GC	509..806	CDD:270894	19/80 (24%)
		HNOBA	<817..863	CDD:285003	13/51 (25%)
		CYCc	842..1035	CDD:214485	47/223 (21%)
		Guanylate_cyc	869..1056	CDD:278633	37/169 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810