DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and gcy-17

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001293327.1	Gene:	gcy-17 / 191649	WormBaseID:	WBGene00001542	Length:	1088	Species:	Caenorhabditis elegans

Alignment Length:	291	Identity:	81/291 - (27%)
Similarity:	147/291 - (50%)	Gaps:	44/291 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   257 DQERSLLLSI--------------LPAQIADRLQEDVKNRIERSKQ--QHQQQSQVDLRRSADSQ 305
            ||.||||..:              :....|..|:|:|.   ||:|:  :.|::|.|.|.|.....
Worm   801 DQVRSLLRGMNDGKKGNLMDHVFNMLETYASTLEEEVN---ERTKELVEEQKKSDVLLYRMLPKT 862

  Fly   306 TLKRWRQPDHGTLFIEPH--EDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNV 368
            ..::.:    ..:.|||.  |.||:.::|||.:|.|.:.....::|:.|:||:..||...|:.:|
Worm   863 VAEKLK----AGISIEPETFELVTIFFSDVVQFTTLASKCTPLQVVQLLNDLYTIFDSIIEQNDV 923

  Fly   369 LRIKFLGDCYYCVAGLANPNA-DHAKCCVDLGLRMIKDIRDVREKRHL---NIDMRIGVHSGDVL 429
            .:::.:||.|.||:||.:.|. ||.|....:.|..:..:.:.| ..|:   .|::|||::.|.|:
Worm   924 YKVETIGDGYLCVSGLPHRNGHDHIKHIARMSLAFLSSLAEFR-VAHMPSERINLRIGINCGSVV 987

  Fly   430 SGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLD---GEYFFEDGTEKAREDPVL 491
            :||:|....::.::...|:.|:|:|:.|..||:|||.:...||.   |.:..|:     |.:.::
Worm   988 AGVVGLTMPRYCLFGDAVNTASRMESNGKPGRIHVSSEANHLLTHVVGGFRTEE-----RGEVII 1047

  Fly   492 QKHGIRT---FLIKSLRAPMHDPRRRMRERQ 519
            :..|:..   .|.::...|:   :..||:|:
Worm  1048 KGKGVMNTYWLLGENDSVPV---KSNMRKRE 1075

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	10/40 (25%)
		CYCc	254..476	CDD:214485	73/243 (30%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	58/193 (30%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gcy-17	NP_001293327.1	Periplasmic_Binding_Protein_Type_1	25..404	CDD:299141
		ANF_receptor	47..398	CDD:279440
		PKc_like	539..808	CDD:304357	5/6 (83%)
		Pkinase	567..803	CDD:278497	1/1 (100%)
		HNOBA	<824..867	CDD:285003	12/45 (27%)
		CYCc	846..1038	CDD:214485	60/196 (31%)
		Guanylate_cyc	873..1060	CDD:278633	58/192 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900