DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and gcy-15

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001364713.1	Gene:	gcy-15 / 191648	WormBaseID:	WBGene00001541	Length:	1104	Species:	Caenorhabditis elegans

Alignment Length:	317	Identity:	72/317 - (22%)
Similarity:	139/317 - (43%)	Gaps:	54/317 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 IALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVD 297
            |.|:.|.:|.                    ::|:: .:..|:|::|:..|.|..:.:
Worm   824 IGLKRTIMDN--------------------MVSMI-EKYTDKLEKDIAERNEELEAE-------- 859

  Fly   298 LRRSADSQTLKRWRQPD--------HGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHD 354
               .|.|:.|.:...|:        ...:..|..|:.||.::|...:..::.|.....:|:.|:|
Worm   860 ---KAKSEALLKMMLPEVVADSLKLGSNVSAESFENCTVFFSDCPGFVEMSATSKPIDIVQFLND 921

  Fly   355 LFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNAD-HAKCCVDLGLRMIKDIRDVREKRHL--- 415
            |:..||...::::|.:::.:.|.|...:||..||.: ||.....|||.::|.:...: .|||
Worm   922 LYTVFDRIIDQFDVYKVETIADAYMVASGLPVPNGNHHAGEIASLGLALLKAVESFK-IRHLPNE 985

  Fly   416 NIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLD--GEYFF 478
            .:.:|||::||..::||:|....::.::...|:.|:|:|:.|...|::.|.....:||  |.|..
Worm   986 KVRLRIGMNSGPCVAGVVGLKMPRYCLFGDTVNTASRMESNGIPLRINCSGTAKEILDQLGGYEI 1050

  Fly   479 EDGTEKAREDPVLQKHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKANFMHNS 535
            |       |..:::..|....:...:|....|.||....|:..|.:...||.....:
Worm  1051 E-------ERGIVEMKGKGKQMTYFVRGENSDMRRERIIRERVKFASLKKAQIQEKT 1100

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	9/50 (18%)
		CYCc	254..476	CDD:214485	56/235 (24%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	50/187 (27%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gcy-15	NP_001364713.1	Periplasmic_Binding_Protein_type1	2..363	CDD:415822
		PK_GC	553..822	CDD:270894
		HNOBA	<831..879	CDD:400168	11/79 (14%)
		Guanylate_cyc	885..1071	CDD:306677	50/193 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810