DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and gcy-14

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_506660.2	Gene:	gcy-14 / 191647	WormBaseID:	WBGene00001540	Length:	1111	Species:	Caenorhabditis elegans

Alignment Length:	308	Identity:	80/308 - (25%)
Similarity:	150/308 - (48%)	Gaps:	59/308 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 NLLLRYARDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRS-----ADSQTLK 308
            |:|..||         |.|..:::||.:|.|         :.:::|.|.|.|.     ||...|.
Worm   817 NMLETYA---------STLEEEVSDRTKELV---------EEKKKSDVLLYRMLPKMVADKLKLG 863

  Fly   309 RWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKF 373
            :..:|       |..|.||:.::|||.:|.|.......::|..|:||:..||...|:.:|.:::.
Worm   864 QTVEP-------ETFEQVTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKVET 921

  Fly   374 LGDCYYCVAGLANPNA-DHAKCCVDLGLRMIKDIRDVREKRHL---NIDMRIGVHSGDVLSGVIG 434
            :||.|.||:||.:.|. :|.:....:.|..:..:...| .:||   .|::|||::.|.|::||:|
Worm   922 IGDGYLCVSGLPHRNGNEHIRHIARMSLGFLSSLEFFR-VQHLPSERINLRIGINCGSVVAGVVG 985

  Fly   435 AAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLD---GEYFFEDGTEKAREDPVLQKHGI 496
            ....::.::...|:.|:|:|:.|..|::||:.:...:|.   |.:..|     :|.:.:::..|:
Worm   986 LTMPRYCLFGDAVNTASRMESNGKPGKIHVTAEANQMLTQVVGGFRTE-----SRGEVIIKGKGV 1045

  Fly   497 ---------RTFLIKSLRAPMH---DPRRRMRERQ----VKKLSEASK 528
                     ::.:..|.:||..   :|.||...|.    ::|:||.::
Worm  1046 METYWLLGEQSRISVSAQAPREKTPEPPRRQSVRSISPIIEKMSEETQ 1093

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	10/34 (29%)
		CYCc	254..476	CDD:214485	65/233 (28%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	52/197 (26%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gcy-14	NP_506660.2	PBP1_NPR_GC_like	21..423	CDD:107347
		ANF_receptor	43..418	CDD:279440
		PKc_like	535..800	CDD:304357
		HNOBA	<817..860	CDD:285003	16/60 (27%)
		CYCc	839..1031	CDD:214485	57/199 (29%)
		Guanylate_cyc	866..1053	CDD:278633	53/199 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810