DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXD and gcy-9

DIOPT Version :9

Sequence 1:NP_620469.2 Gene:ACXD / 38284 FlyBaseID:FBgn0040507 Length:1162 Species:Drosophila melanogaster
Sequence 2:NP_509897.3 Gene:gcy-9 / 191645 WormBaseID:WBGene00001536 Length:1081 Species:Caenorhabditis elegans


Alignment Length:467 Identity:100/467 - (21%)
Similarity:180/467 - (38%) Gaps:158/467 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 VVLGVNF-RSELVSKHG------------WVVYATSWLAVCVMVLMDIGLNVYHATSHN------ 153
            ||.|:|| .:..:..||            |.|..|::....|         ::....||      
 Worm   636 VVKGLNFLHTSPLLHHGMLCLQNCLVDSNWTVKLTNFATEAV---------IFEKLDHNELRPFI 691

  Fly   154 --------DILNPIYD----------------------------AYTLYAIYMFM-PVPYLLQPF 181
                    |:.:|..|                            :..:||:.|.: .:.:.::||
 Worm   692 NTDSESADDVSDPTKDFARKKYLQQAPEIIREIVTTKTIPEGSQSADIYALGMVLYQILFRVEPF 756

  Fly   182 VLGSAVTFCYIINYSF------VITAKDDNQM------HSILNEAI---YLSCVNLLGIFF---- 227
                     :..|.|.      :..|.||:|:      .|...|..   .|||:....:..    
 Worm   757 ---------HERNKSINKLMETLAMANDDDQLIRPTFPSSNTGEGYNLQLLSCIEACWLEIPEMR 812

  Fly   228 ------RLMRDIALRTT----FLDR-----RQYVE--ENL------LLRYARDQERSLLLSILPA 269
                  |.|.:..|::|    .:|:     .:|..  ||:      ||..|:.|...||.|:||.
 Worm   813 PPIKKVRTMVNANLKSTGKGSLVDQMMKMMEEYTANLENMVRDRTALLEEAQKQADRLLNSMLPK 877

  Fly   270 QIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVV 334
            .||    ||:|  |.:                               .:..:.:...|||::|:.
 Worm   878 SIA----EDLK--IGK-------------------------------PVLPQLYSCATVLFSDIR 905

  Fly   335 NYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNAD-HAKCCVDL 398
            .:|.:::|....::|..|:|:|..||....:::..:::.:||.|..|:|:...|.: ||:...|:
 Worm   906 GFTRISSTSTPLQVVTFLNDMFSGFDAIIAKHDAYKVETIGDAYMIVSGVPTENGNSHAQNIADV 970

  Fly   399 GLRM---IKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATG 460
            .|:|   |.:.:.......|.: :|||.|||.|.:||:|.|..::.::...|:.|:|:|:||...
 Worm   971 ALKMRAFICNFKLAHRPEELMM-VRIGFHSGPVAAGVVGLAAPRYCLFGDTVNTASRMESTGVAN 1034

  Fly   461 RVHVSQKTLSLL 472
            ::.:|:...:||
 Worm  1035 KIQISEGAYNLL 1046

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXDNP_620469.2 AC_N <42..284 CDD:292831 54/273 (20%)
CYCc 254..476 CDD:214485 58/223 (26%)
Nucleotidyl_cyc_III 321..503 CDD:299850 45/156 (29%)
CYCc 856..1117 CDD:214485
Nucleotidyl_cyc_III 878..1142 CDD:299850
gcy-9NP_509897.3 Periplasmic_Binding_Protein_Type_1 66..416 CDD:299141
ANF_receptor 69..404 CDD:279440
PKc_like 550..820 CDD:304357 32/201 (16%)
HNOBA <837..883 CDD:285003 15/49 (31%)
CYCc 862..1054 CDD:214485 58/223 (26%)
Guanylate_cyc 889..1076 CDD:278633 45/159 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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