Protein Alignment ACXD and acy-2

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_504553.1
• Gene: acy-2 / 191607
• WormBaseID: WBGene00000069
• Length: 1080
• Species: Caenorhabditis elegans
• Alignment Length: 1221
• Identity: 328/1221 - (26%)
• Similarity: 536/1221 - (43%)
• Gaps: 289/1221 - (23%)

  Fly    38 SYLVRKCRNLELEDSYDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLTT---PEIK--------- 90
            |.||:..|:|:....:.:::..|.  |.:..|||....:.::.:|:|..   |:.|
 Worm    16 SVLVKHWRSLDKARLHTIHLWLLL--YAAAQIFIEYYFSEVYAVLMLEADDRPQSKENHEKVKKW 78

  Fly    91 -----YVYVDMVAYMCSGLVIWVVLGVNFRSELVSKHGWVVYATSWLAVCVM-----------VL 139
                 |..:..:||:     |.....:..|.   .|.|..:...| |::||:           |:
 Worm    79 SPFCFYASIFFIAYL-----ILTCFAIRIRQ---PKEGMGLVLVS-LSLCVLLPAFSWILHLPVV 134

  Fly   140 MDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDD 204
            :.:.....|...|:.  :.:|.:..:.::..|..:|...:.|.:   |...:|:....:|.|.:.
 Worm   135 IFVSRERIHTNEHDH--SALYTSLCIASVIQFFILPRHRRIFFV---VAVSWIVANFLLIVAINW 194

  Fly   205 NQMHSILNEAIYLSCVNLL---GIFFRL-----------MRDIALRTTFLDRRQYVEENLLLRYA 255
            :.::  :|.....||::|.   |:...:           ..:||.:.|     :.|.....|...
 Worm   195 DALN--VNTLFMCSCLSLFLHQGVIALVGVVADSNEAGNRAEIARKLT-----EAVYRRTELETL 252

  Fly   256 RDQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFI 320
            :|::..||||::||.:||::.:.:       .|.....|.|::.|:..:.|.......|   |.:
 Worm   253 KDRQEQLLLSVIPAYLADQVSKSI-------IQSSSTGSTVEVPRTGKNNTKNHKLFHD---LHV 307

  Fly   321 EPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLA 385
            :.|::|::|:||:||:|.|...|..|.||..|::|:.:||..::....:||||||||||||:|:.
 Worm   308 QVHDNVSILFADIVNFTVLAAQLTAKDLVRTLNELYSKFDRDAQRLQCMRIKFLGDCYYCVSGMP 372

  Fly   386 NPNADHAKCCVDLGLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIA 450
            ....:||..||.:||.||..|:.||....::::||||||:|.||.|::|..||||||||.||.:|
 Worm   373 VNRPNHADMCVVMGLEMINTIKQVRIATGVDVNMRIGVHTGSVLCGIMGLRKWQFDIWSDDVTLA 437

  Fly   451 NRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLIKSLRAPMHDPRRRM 515
            |.:|:.|..|.||:::.|..:|.|:|...|..   .:||.:..:|..|:.|      :.|
 Worm   438 NHMESAGVPGAVHITKSTKDMLLGDYCIVDAN---TDDPHVVSYGQPTYHI------LPD----- 488

  Fly   516 RERQVKKLSEASK-ANFMHNSTLHQYNQVRNQAKLEMCRELDKM--------PIGRIQLTKVFRR 571
                  |.|...: |:...||.|.....:  |:::.|..::.||        |.... ..|.|..
 Worm   489 ------KTSAIERTASIYRNSRLSTSPAL--QSRMSMKAKVSKMVEFWGAETPFANF-TKKKFSA 544

  Fly   572 S--TRLTQDEI-EEETFRRNISSCCLF-FRIRNWEFQYIKE------PDVMLKYSIALAWVIYMG 626
            |  ..|..||| ...|:...|.|..|. ..:.|:.|..|..      |.:  ..|..|.|.....
 Worm   545 SHDPALITDEIARRPTYINTIPSMTLIENNLTNFSFNNINSMFNCELPTI--PASPKLLWPFSRK 607

  Fly   627 LLTIQLLSKDARYHYWYIDGTTIILLTMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDE 691
            .:|..|              :..:|||.:.|.|.:..|                |...|:..||.
 Worm   608 SITCNL--------------SDCVLLTFVCIPSAFANL----------------LLCSLYCPSDV 642

  Fly   692 MQRNVVIRVVMYFLIIFSYCAVAIMQVVG--CSSDEDYAD---------------------LDPT 733
            :|:   |.:..:|.||    .:|::.::|  ||    ||.                     :..:
 Worm   643 LQQ---ISLQQFFTII----GLAMLSLLGRVCS----YAGPLITMVAFLLSSCIPIGPHIIIKKS 696

  Fly   734 YDERVQCFHPWI-LTNCMTLVIGMSFLFTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYANSPST 797
            ..|.|..|:..| |.:|::.::.: |:..|:|:..: ||     :.:|..|:  |..:.:..|:.
 Worm   697 KLEGVMAFNSLIFLPSCVSHLVSV-FILYRLPYSHR-CF-----LFFADFVI--FQVLLSLFPAY 752

  Fly   798 NVNFNAKYS--HI--------LLMIITFGIFHL--MERQTEFIAKVDYNWKRQLIKKQEDALITN 850
            .......|.  |:        ||:::.|.|..:  .||:.|....|.:.      .::.|.....
 Worm   753 GAEVYVGYMGYHLSVVSISLSLLVVLLFFIDWITNYERKRESACHVSFQ------NEERDVETMQ 811

  Fly   851 DTIKVLLTNILPTHVADFYLS-NQLQNELYYEEYDNVAVMFASIKNF-------DTDK--IGLRV 905
            |..|:|:.||||:.||..:|| ::..||||..:::||.||||||.||       ||::  ..||:
 Worm   812 DINKILIENILPSSVAAKFLSPDRAVNELYARQHENVCVMFASIPNFKDFWSEWDTNRKLECLRL 876

  Fly   906 LNEIICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSR 970
            ||||:|:||.:|:|...| .|||||....|||||.||:.|.::
 Worm   877 LNEIVCEFDKLLSKPKFS-SVEKIKTVGSTYMAAAGLNESEAD---------------------- 918

  Fly   971 YDGARSSNADGVQRVPYGNGSNIALDLDLER---GQYEGNVITSGPRISSTHNGSSSNEVVRVMA 1032
            ||                       |:.||:   |:|..|:          .:|:.:.....:|.
 Worm   919 YD-----------------------DIYLEKQNSGKYNNNI----------RHGNMAFRNANLMI 950

  Fly  1033 EFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRM 1097
            ||||.:.:.:...|.::.| .:|       ||||:|.|..:|||:|..||.||||||.||:||||
 Worm   951 EFALAMSQILDALNRDSFQ-NFE-------LRIGMSVGPLVAGVIGAQKPQYDIWGNTVNLASRM 1007

  Fly  1098 DSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVKG-RGNIPTYIIGIDSE 1147
            |:.|.|.:|..|.:....|:....:...||...||| :..:.|::|.:||:
 Worm  1008 DTHGEPRKIHATTDMGRVLQTGGYRVQSRGKIRVKGVKEPMETFLIEVDSK 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	52/283 (18%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	79/181 (44%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	92/276 (33%)
acy-2	NP_504553.1	Guanylate_cyc	307..486	CDD:425528	79/187 (42%)
		Guanylate_cyc	840..1054	CDD:425528	92/277 (33%)