DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and gcy-11

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001359843.1	Gene:	gcy-11 / 181745	WormBaseID:	WBGene00001537	Length:	1168	Species:	Caenorhabditis elegans

Alignment Length:	468	Identity:	98/468 - (20%)
Similarity:	195/468 - (41%)	Gaps:	110/468 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 VIWVVLGVNFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSH-----NDILN------- 157
            ::|      |..|::.::. |.:..|.|.:....:..:.:.:|.....     :|:|:
Worm   778 LLW------FAPEIIRRYA-VKHDLSKLELAKADIYSLAIVLYEIYGRQGPFGDDLLDSDEIIEQ 835

  Fly   158 ---PIYDAYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSILNEA----I 215
               |...|.|...|::....||     .|.|.|..|::.:.:...:.|...::...|::.    |
Worm   836 LKFPDGGALTRPDIHLITKAPY-----PLASVVEKCWVEDPASRPSIKKVRELLKPLSKGLKGNI 895

  Fly   216 YLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRLQEDVK 280
            ..:.:|||..:...:.|:     ..:|.:.:|:.      |.:..||||.:||..:|:.|:..
Worm   896 ADNIMNLLDRYRNNLEDV-----IKERTEQLEDE------RKRNESLLLQLLPKSVANSLKNG-- 947

  Fly   281 NRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDV 345
                                           ||    :..|.::.|::.::|:|.:|.|::....
Worm   948 -------------------------------QP----VDAEFYDSVSIYFSDIVGFTALSSKSTP 977

  Fly   346 KKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNAD-HAKCCVDLGLRMIKDIRDV 409
            .::|..|::|:..||...::::..:::.:||.|..|:||...|:. ||.......|.::..|:..
Worm   978 LQVVNMLNNLYTNFDTIIDKFDCYKVETIGDAYMFVSGLPEVNSYLHAGEVASASLELLDSIKTF 1042

  Fly   410 R------EKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKT 468
            .      ||    :.:|||.|:|.|::||:|....::.::...|.|||.:|::|...|:.:|...
Worm  1043 TVSHCPDEK----LRLRIGNHTGPVVTGVVGIRMPRYCLFGDTVIIANMMESSGEPMRIQISSDA 1103

  Fly   469 LSLL--DGEYFFEDGTEKAREDPVLQ-KHGIRTFLIKSLRAPMHDPRRRMRERQVKKLSEASKAN 530
            ..|:  .|.|..|.     ||..||: |..:.|:.       |:|..:..|..::    .|.:..
Worm  1104 YELILKCGGYVTEQ-----REKIVLKNKLEVMTYW-------MNDYSKDARLARL----VAHQEK 1152

  Fly   531 FMH-NSTLHQYNQ 542
            |.| ...:|::|:
Worm  1153 FPHLEHLIHKFNK 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	37/197 (19%)
		CYCc	254..476	CDD:214485	54/230 (23%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	51/191 (27%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gcy-11	NP_001359843.1	Periplasmic_Binding_Protein_type1	<234..452	CDD:385651
		PKc_like	640..890	CDD:389743	21/123 (17%)
		CYCc	923..1116	CDD:214485	55/239 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900