DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and gcy-32

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_506452.5	Gene:	gcy-32 / 179887	WormBaseID:	WBGene00001552	Length:	684	Species:	Caenorhabditis elegans

Alignment Length:	656	Identity:	141/656 - (21%)
Similarity:	242/656 - (36%)	Gaps:	190/656 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SYFDSAIE------YNRSNPISLARTSSQAQTVQNEKNWE--------------WSYLVRKCR-N 46
            |.|:|..|      |:.::...|..:.|....|..::.||              |..|||... |
Worm    29 SGFESGKENIMNHYYSDTDTYVLVDSVSLVLKVTKDQVWEMYGGFLITYSMEIGWDELVRSMSPN 93

  Fly    47 LELEDSYDLYMRRLRVGYL----SLFIFI-HVAV-------------TVIHTLLL---LTTPEIK 90
            |:              |:|    ||..|| ||..             |...||||   ...|.:.
Worm    94 LK--------------GFLDNLDSLHYFIDHVVYKANLRGPSFRCEETPDGTLLLHYFTGRPGLY 144

  Fly    91 YVYVDMVAYMCSGL----VIWVVLGVNFRS------ELVSKHGWVVYATSWLA----------VC 135
            ::...:|..:...:    :..||.|...||      |.|.:|  ||:..:.|:          |.
Worm   145 HIVKGVVKEVAKRVFDLDITLVVQGRTQRSVHMNNGERVEEH--VVFLINNLSEPRRDSEGSEVS 207

  Fly   136 VMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFM----------------PVP-YLLQPFVL 183
            ::.    ..|....|..:|.|....|.::....|.|:                .:| .||||
Worm   208 LLT----STNANFPTIVDDTLGISLDDFSKALPYHFVIDESCKLVQCGSELHNHIPNELLQP--- 265

  Fly   184 GSAV----------------TFCYIINYSFVITAKDD----NQMHSILNEAIYLSCVNL------ 222
            |:.:                ..|..||..||:..|..    ..|.::..|.:......|
Worm   266 GTPILRIFEINRPQIPLDFENICNFINAVFVLQVKTSPLKKKHMDAMSQEELKQEMETLDEDATN 330

  Fly   223 ---LGIFFRLMRDIALRTT-----FLDRRQYVEENLLLRYA--------RDQERSLLLSILPAQI 271
               .|...:|...:.|..:     :|........|.|::|.        .|..|.|:|  |..|
Worm   331 ELTQGHHLKLKGQMMLLASKKHIIYLCSPYVTSINELMQYGMRLTAMPLHDATRDLIL--LNQQ- 392

  Fly   272 ADRLQE-DVKNRIERSKQQHQQQS-QVDLRRSADSQTLK-----RWRQPDHGTLFIEPHE-DVTV 328
              ||.: :|..::|.:.:|.:..: :::|.|......||     |..|.......||..| :.||
Worm   393 --RLSDVEVNLQLEANNEQLETMTRELELERQKTDSILKDMLPRRIAQQLLSGEHIEACEHEATV 455

  Fly   329 LYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAK 393
            ::.|:..:.........|.:|..|:::|.:.|.......|.:::.:.|.|..|:|:.:...:||:
Worm   456 MFCDLPAFQQAIPQCSPKDIVNMLNEIFRKLDRIVVIRGVYKVETVSDSYMAVSGIPDYTPEHAE 520

  Fly   394 CCVDLGLRMIKDIRDVREKRHLNID--------MRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIA 450
            ....:.|.|:.:.|.|       ||        :|||:|||.:.:||:|....::.::.:.|.:|
Worm   521 NMCHVALGMMWEARSV-------IDPVSKTPFLLRIGIHSGTITAGVVGTVHPKYCLFGETVTLA 578

  Fly   451 NRLEATGATGRVHVS----QKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRT--FLIKSLRAPM- 508
            :::|:.|..|::..|    ||.:.  .|.:.|   :.:.|.|  :::.|:..  ||.:||:..:
Worm   579 SQMESLGMAGKIQCSKWAYQKAME--TGRFEF---SPRGRID--VKQRGLTETYFLTRSLKKSIW 636

  Fly   509 ----HD 510
                ||
Worm   637 EIIDHD 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	68/343 (20%)
		CYCc	254..476	CDD:214485	60/249 (24%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	47/196 (24%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gcy-32	NP_506452.5	HNOB	3..167	CDD:285002	31/151 (21%)
		HNOBA	226..440	CDD:285003	42/221 (19%)
		CYCc	419..608	CDD:214485	48/197 (24%)
		Guanylate_cyc	452..627	CDD:278633	43/188 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810