DRSC/TRiP Functional Genomics Resources

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Protein Alignment ACXD and gcy-18

DIOPT Version :9

Sequence 1:NP_620469.2 Gene:ACXD / 38284 FlyBaseID:FBgn0040507 Length:1162 Species:Drosophila melanogaster
Sequence 2:NP_502449.2 Gene:gcy-18 / 178237 WormBaseID:WBGene00001543 Length:1113 Species:Caenorhabditis elegans


Alignment Length:1251 Identity:253/1251 - (20%)
Similarity:410/1251 - (32%) Gaps:460/1251 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   109 VLGVNFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLYAI---YM 170
            ::|.:...|:||:.   ..:.|:..|.|      ...:||.......:.| |.|..|.|:   ..
 Worm    83 LVGDDIEFEIVSRQ---ACSESFEGVAV------AAELYHVHQVRAFIGP-YCAAELEAVTKMAT 137

  Fly   171 FMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSIL-------NEAIYLSCVNLLGIFFR 228
            |..:|                ||:||.|..|..|..::..|       ..:|..:.|.||..:..
 Worm   138 FWNIP----------------IISYSSVPNAVSDRSVYKTLARVSSKNTNSIAEATVALLLHYKW 186

  Fly   229 LMRDIALRT--TFLDRRQYVEE-------NLLLRYARDQERSLLLSILPAQIADRLQEDVKNRI- 283
            |...||..|  |..:|....||       .::.:...|:.......:...|:.| |..:.:..| 
 Worm   187 LKVAIATNTGSTAFERVSIFEEIMHREGVTIVKKVMFDENTDANEMMNSGQLGD-LAANARIIIC 250

  Fly   284 ------ERSKQQHQ-------------------QQSQVDLRR--SADSQTLKRWRQPDH------ 315
                  |.||:..|                   |....||..  .||.:.|:|.:  ||      
 Worm   251 LFSSTKELSKEFMQATYTMRMNNAEYAYIIPWLQSGTKDLTPWIGADGEMLQRVK--DHYANAII 313

  Fly   316 -----------GTLFIEPHE---------DVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFD 360
                       .:.|:|..|         |||    ::..|.||..:|.:..|  |:..:....|
 Worm   314 VDDVNGFDDSVVSSFVEKIEKHGMQKSDIDVT----NINGYLHLFDSLKLYAL--AIRKVLNETD 372

  Fly   361 IASEEY---------NVLRIKFLG-------------------------------DCYYCVAGLA 385
              :|.|         .:.|:||.|                               ..:|     .
 Worm   373 --NEAYVTNGQFIWNRMRRMKFEGVVSRSSSEENKDAGAIGTVLMDDVADRAPIFSAFY-----I 430

  Fly   386 NPNADHAKCCVDLGLRMIKDIRDVREKR---HLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDV 447
            :||.|.....|::...:|.:...::.|.   .|.|:        |:.||.     |..:..|..:
 Worm   431 SPNRDKVMKMVNMESELISNCDGLKNKSGCFQLKIN--------DIKSGF-----WPSEDGSMPL 482

  Fly   448 D----------IANRLEATGATGRVHVSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLIK 502
            |          .:..||.  :.|.:.:   .|.|:...:||   ..:..|:..|:|...|.|   
 Worm   483 DEPICGYRGQRCSYLLEI--SVGSLII---LLILISVVFFF---LFRYCENKQLEKMPWRIF--- 536

  Fly   503 SLRAPMHDPRRRMRERQVK----------KLSEASKANFMH-------NSTLHQYNQVR------ 544
                  ||..:.:.|.|||          |||........|       ::|.|:|.|.|      
 Worm   537 ------HDDLQFIDEEQVKSMMSVGSVTTKLSNIQTGQKQHAIIGVNTHTTYHRYKQRRPIKFIK 595

  Fly   545 ------NQAKLEMCRELDKMPIG--------RIQLTKVFRRST--------RLTQDEIEEETFRR 587
                  .|.|..:...|:.. :|        .:.|.|...|.|        .:..||.....|.|
 Worm   596 EDMQLLTQMKQAVHDNLNPF-LGAAFNEKEEMLVLWKFCSRGTIQDIIYNANVVLDEKFHGAFVR 659

  Fly   588 NISS-------------------CCLFFRIRNWEFQYIKEPDVMLKYSIA---LAWVIYMGLLTI 630
            :|:.                   |||.  .|||   .:|..|    |.||   ..|. ..|.:.|
 Worm   660 DITLGLEYLHASPIGYHGSLTPWCCLI--DRNW---MVKLSD----YGIANPLERWE-KQGAIEI 714

  Fly   631 QLLSKDARYHYWYIDGTTIILLTMLLI------------VSWYKKLWIMYMSDADVSSPNGRLSG 683
             ..:||:.........|:||.:...|:            .||.|:..:.            |.:|
 Worm   715 -AAAKDSDDKSQASQATSIIYMAPELLKNRETNKRRGMDQSWVKQSMLR------------RQAG 766

  Fly   684 FLFRMSDEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGCSSDEDY-ADLDPTYDERVQCFHPWILT 747
            .::...          :|||.::   :.::........|...|| ||...|....:|        
 Worm   767 DIYSFG----------MVMYEIL---FRSLPFRDNTNISELVDYLADGSKTVSPEIQ-------- 810

  Fly   748 NCMTLVIGMSFLFTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNFNAKYSHILLMI 812
            |.|.|...::.|       ::.|:|                    .:|....:......:..:::
 Worm   811 NQMGLHPDLNAL-------LRDCWS--------------------ENPEIRPSIRRVRLNTEMVL 848

  Fly   813 ITFGIFHLMERQTEFIAKVDYNWKRQLIKKQ---EDALITNDTIKVLLTNILPTHVADFYLSNQL 874
            .|.|  .|:::..:.:.:...|.::.:.::.   |:|.|..|.   |||.:||.:||     |:|
 Worm   849 KTKG--SLVDQMMKMMEQYANNLEKLVAERTGMLEEANIRADQ---LLTQLLPAYVA-----NEL 903

  Fly   875 Q--NELYYEEYDNVAVMFASIKNFDTDKIG------LRVLNEIICDFDDVLNKYSQSLRVEKIKV 931
            :  ..:..:.|.:..::|:.|..|.|...|      :.:||.:...||:.:.: ::|.:||.|..
 Worm   904 KMGRSVAPKLYSSATILFSDIVGFTTICSGSTPLEVVNMLNGLYTGFDECITR-NKSYKVETIGD 967

  Fly   932 ANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALD 996
            |   ||...|:          |:             .:.|:.:|             |.:|.|||
 Worm   968 A---YMVVSGI----------PE-------------ENEYNHSR-------------NIANTALD 993

  Fly   997 LDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYG 1061
            :   |....|..|...|    ||.       ||                                
 Worm   994 M---RQYLTGYQIPHRP----THR-------VR-------------------------------- 1012

  Fly  1062 MLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFN--IQCN 1124
             .|.|...|...|||||::.|.|.::|:.||::|||:|||.||.||::|...:.:|..:  ....
 Worm  1013 -CRWGFHTGSVAAGVVGLTCPRYCLFGDTVNVSSRMESTGTPGMIQMSEEAHMHIRAHHPVFTTT 1076

  Fly  1125 YRGMTFVKGRGNIPTY 1140
            .||...|||:|...|:
 Worm  1077 ERGEVQVKGKGTCRTF 1092

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXDNP_620469.2 AC_N <42..284 CDD:292831 41/200 (21%)
CYCc 254..476 CDD:214485 57/328 (17%)
Nucleotidyl_cyc_III 321..503 CDD:299850 45/243 (19%)
CYCc 856..1117 CDD:214485 67/268 (25%)
Nucleotidyl_cyc_III 878..1142 CDD:299850 66/271 (24%)
gcy-18NP_502449.2 Periplasmic_Binding_Protein_Type_1 87..448 CDD:299141 77/402 (19%)
ANF_receptor 87..395 CDD:279440 71/344 (21%)
PKc_like 549..846 CDD:304357 65/368 (18%)
HNOBA <857..903 CDD:285003 13/53 (25%)
CYCc 882..1073 CDD:214485 71/285 (25%)
Guanylate_cyc 909..1095 CDD:278633 66/271 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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