Protein Alignment ACXD and acy-1

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_497970.1
• Gene: acy-1 / 175622
• WormBaseID: WBGene00000068
• Length: 1253
• Species: Caenorhabditis elegans
• Alignment Length: 1342
• Identity: 290/1342 - (21%)
• Similarity: 495/1342 - (36%)
• Gaps: 406/1342 - (30%)

  Fly    43 KCRNLELEDSYDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSGLVIW 107
            ||...:|.|       |.|.|      .|::||.:....|.|...:..::. ..:..:|...:|:
 Worm    56 KCSFSQLRD-------RFRSG------LIYIAVVIAAWTLYLALFDRTFIQ-HWIVSLCLCAIIF 106

  Fly   108 VVLGVNFRSELVSKHGWVVYATSWLAVCVMVLMDIGLNVYHATSHNDILNPIYDAYTLY----AI 168
            .:...   :...:::......||:|  |..::..:.|.::.|.:....:.|:....|.:    .|
 Worm   107 AMFAF---TACAAQYQRFYMPTSFL--CTFLICLVTLLIFSAENQAAFMTPVASLATSFQVVLLI 166

  Fly   169 YMFMPVPYLLQPFVLGSAVTFCYIIN--YSFVITAKDDNQMHSILNEAIYLSC-----VNLLGIF 226
            |..:|:|..|           |.:|.  ||.:....:.|::.  |.||.|:..     |:|||:.
 Worm   167 YTVIPLPLYL-----------CILIGIIYSILFEILNKNKIG--LEEAGYIKLVLHAGVHLLGVH 218

  Fly   227 FRLMRDIALRTTFLDRRQYVEENLLLRYARDQERS----LLLSILPAQIADRLQEDVKNRIERSK 287
            ..::..:..|.|||.    |.:::|.|...:.|..    ::.|::|.::||.|.:|. :.:.|..
 Worm   219 LFILTQVRQRKTFLK----VGQSMLARKDLELETQFKDHMIQSVMPKKVADELLKDA-SELRRPS 278

  Fly   288 QQHQQQSQVDLRRSADSQTLK---RWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLV 349
            ..:....:.......|....|   .:|:....|:.:  ..:|::|:||:..:|.:::.....:||
 Worm   279 ASNDSNCRTSNATQVDQPLAKMVPEYRKFRPFTMNL--MTNVSILFADIAGFTKMSSNKSADELV 341

  Fly   350 EALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKDIRDVREKRH 414
            ..|:|||.|||.......:.:|..||||||||||...|..|||...|::||.||..||.....|.
 Worm   342 NLLNDLFGRFDTLCRLRGLEKISTLGDCYYCVAGCPEPCDDHACRTVEMGLDMIVAIRQFDIDRG 406

  Fly   415 LNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLDGEYFFE 479
            ..::||:|:|:|.|:.|::|..:::||::|.||.:||.:|::|..||||||:.|..||.|.|..|
 Worm   407 QEVNMRVGIHTGKVMCGMVGTKRFKFDVFSNDVTLANEMESSGVAGRVHVSEATAKLLKGLYEIE 471

  Fly   480 DGTEKAREDPV-LQKHG---------IRTFLIK------------------SLRAPMHDPRRRMR 516
            :|.:  .:.|: :|..|         ::||.||                  ||.:.....:..::
 Worm   472 EGPD--YDGPLRMQVQGTERRVKPESMKTFFIKGRINDGVEEEVMQVQEVESLHSQKSSKKSTLK 534

  Fly   517 ERQVKKLSEASKANFMHNSTL------------------HQYNQVRNQAKLEMCRELDKMPIGRI 563
            ::..:||    |.|..::..:                  ::..|:..:....:|...|......:
 Worm   535 QKWAEKL----KMNHTNSYPMRAAAREGGGSLRIKLAERNRSTQLLPKESNSICIMEDNRKSASL 595

  Fly   564 Q--LTKVFRRSTRLTQDEIEEETFRRNI------------------SSCCLFFRIRNWEFQYIKE 608
            |  .|..|..|...|.:...|.....::                  |...|..:..|.:...:..
 Worm   596 QALATNNFNGSNTDTNNTYSERGVAGSVSKKSVAGSESNSIKGSRSSGLQLSLQDGNSDLNSVGG 660

  Fly   609 PDVML----------------KYSIALAWVIYMG----------------LLTIQLLSKDA--RY 639
            .|..:                .:...||.||..|                ..|::...||.  .|
 Worm   661 LDTAISHHHNAASLTRFDTDNNFDQRLAMVIGQGEGGFDKGFWNHHDSLNKWTLRFNEKDVEEEY 725

  Fly   640 HYWYIDGTTIILLTMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFL------FRMSDEMQRNVVI 698
            ...::|.:.....:....|..:|          |:....|...|..      :|.|     .|.|
 Worm   726 RAHFVDSSERYTASKKGHVERHK----------DLMEQGGEKDGITGSTVNKYRYS-----GVFI 775

  Fly   699 RVVMYFLIIFSYCAVAIMQV------------------------VGCSSDEDYADLDPTYDER-- 737
            .:::..||.....|||||.|                        :|.          |....:
 Worm   776 DIIVATLIFVISGAVAIMSVRPFPLSLIAYFPFAAAILILTIVLIGL----------PLLARKKS 830

  Fly   738 VQCFHPWILTNCMTLVIGMSFLFTRIPFIIKSCFSALIMIGYAVLVVSEFN-----------FIY 791
            .||.:.|:..:    :||:..:|  :|..:..|...|...|....|:..:.           |.:
 Worm   831 FQCANQWMPRH----LIGLLLIF--LPIGVAICIMPLCQSGDCANVILNYRLAFSYVTILAIFAH 889

  Fly   792 ANS------PSTNVNFNAKYSHIL-LMIITFGIFHLMERQTE----------------------- 826
            .|.      |.|.........||. :....|.:.||:|.|..
 Worm   890 CNFSQLAAWPKTTAAVFIGLLHIAGVFYCEFNLKHLVEEQDTCNVTAIMIPPIRKGLNYTIALNS 954

  Fly   827 ----------------------------FIAKVDYNWKR----------QLIKKQEDALITNDTI 853
                                        .:|.::|.::.          |..:..|...|..|..
 Worm   955 TSARTLSQDFGSPLFIWELLLDVILSIVLVAFLNYQFETAFRMSFFGDVQARRDTERMQIVRDQA 1019

  Fly   854 KVLLTNILPTHVADFYLSNQLQNEL-YYEEYDNVAVMFASI--------KNFDTDKIGLRVLNEI 909
            ..||.|::|.|..:     .|:.:. |.|.::.|.|:||||        :||:..:..||||||:
 Worm  1020 DWLLNNVIPAHAVE-----SLKTDTKYSENHETVGVLFASITNWNDMYEENFEGGREFLRVLNEV 1079

  Fly   910 ICDFDDVLNKYSQSLRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGA 974
            |.|||::|:: .....:||||.....||||.||:..|.:.:..|:
 Worm  1080 IGDFDELLDR-PDFTHIEKIKTIGPAYMAASGLNPERKKNMLHPK-------------------- 1123

  Fly   975 RSSNADGVQRVPYGNGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLM 1039
                                                               |.:..|.:|||.:.
 Worm  1124 ---------------------------------------------------EHLYQMVDFALAVQ 1137

  Fly  1040 RTMRRFNTENMQTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPG 1104
            ..:..||.:.:..::       :.::|::.|...|||:|.:|.:|||||:.||:||||.||||..
 Worm  1138 HVLSVFNEDLLNFDF-------VCKLGLNIGPVTAGVIGTTKLYYDIWGDTVNIASRMYSTGVLN 1195

  Fly  1105 QIQVTENTALKLREF---NIQCNYRGMTFVKG-RGNIPTYII 1142
            :|||:::|    ||:   ..:..:|....||| .|.:.||::
 Worm  1196 RIQVSQHT----REYLLDRYEFEFRDHIEVKGIDGGMDTYLL 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	54/255 (21%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	74/209 (35%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	75/276 (27%)
acy-1	NP_497970.1	AcyC	61..504	CDD:441717	131/483 (27%)
		Guanylate_cyc	317..503	CDD:425528	73/187 (39%)
		Nucleotidyl_cyc_III	1041..1235	CDD:448371	75/276 (27%)