DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and gcy-35

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_001252131.1	Gene:	gcy-35 / 173202	WormBaseID:	WBGene00001555	Length:	688	Species:	Caenorhabditis elegans

Alignment Length:	487	Identity:	102/487 - (20%)
Similarity:	193/487 - (39%)	Gaps:	134/487 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 TVIHTLLLLTTPEIKYVYVDMVAYMCSGLVIWVVLGVNFRSELVSKHGWVVY-----ATSWLAVC 135
            |.:..||.|..||:.:.| :.:.|..:.|.::.:.|:          |.:|:     |.:.|...
Worm   258 TRVTDLLELVHPEVPFSY-ESIKYYKNSLFVFRLKGL----------GDIVHNANDEAKTVLLKG 311

  Fly   136 VMVLMDIGLNVYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVIT 200
            .||.:|.|                     .|.:||                   |.:    .|.|
Worm   312 SMVFIDEG---------------------KYILYM-------------------CSV----NVTT 332

  Fly   201 AKD---------DNQMHSILNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYAR 256
            .::         |.|.|....:.|.|:...:..:  .|.|  .|..|....::..:|   |...:
Worm   333 VRELIERNLHLSDMQRHDGTRDVIMLNQSRMSQV--ELNR--TLEETTKKLKKMAQE---LEIEK 390

  Fly   257 DQERSLLLSILPAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIE 321
            .:...||..::||.:||.|                        ||..:...|.:
Worm   391 QKTDELLCELMPASVADSL------------------------RSGKAMDAKEF----------- 420

  Fly   322 PHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLAN 386
              .|.|:|:.|:|.:|::........:|..|:||::|||.....::..:::.:||.|..|.|:..
Worm   421 --ADCTLLFTDIVTFTNICAMCTPYDVVTLLNDLYLRFDRLVGLHDAYKVETIGDAYMIVGGVPE 483

  Fly   387 PNADHAKCCVDLGLRMIKDIRDVREK-RHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIA 450
            ...:||:..:::.:.|:.:.:.|... .|..|.:|:|||.|.|::||:|....::.::...|::|
Worm   484 RCENHAERVLNISIGMLMESKLVLSPITHKPIKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVA 548

  Fly   451 NRLEATGATGRVHVSQKTLSLLDG-----EYFFED-GTEKAREDPVLQKHGIRTFLIKSLRAPMH 509
            |::|:.|...::|||:  ...|:|     .|.|.| |..:.|...::..:    ||.::.|..:.
Worm   549 NKMESNGIQCKIHVSE--TGKLNGLKANPSYVFIDRGNTEIRGKGMMYTY----FLERNDRKSVW 607

  Fly   510 D--PRRRMRERQVKKLSEASKANFMHNSTLHQ 539
            :  .|.|..|:.:....|      :|:.:::|
Worm   608 ELCSRPRSGEQTIDGYME------LHDQSIYQ 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	42/221 (19%)
		CYCc	254..476	CDD:214485	53/227 (23%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	50/188 (27%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
gcy-35	NP_001252131.1	HNOB	3..167	CDD:285002
		HNOBA	218..409	CDD:285003	41/212 (19%)
		CYCc	388..579	CDD:214485	54/229 (24%)
		Guanylate_cyc	415..599	CDD:278633	50/202 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910