Protein Alignment ACXD and Adcy8

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: XP_061499353.1
• Gene: Adcy8 / 1269297
• VectorBaseID: AGAMI1_003825
• Length: 1504
• Species: Anopheles gambiae
• Alignment Length: 1326
• Identity: 353/1326 - (26%)
• Similarity: 539/1326 - (40%)
• Gaps: 422/1326 - (31%)

  Fly    49 LEDSYDLYMRRLRVGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCSGLVI------W 107
            ||.||..|..|.|...|       :.|.|:..:|       |.|...:.....||:.|      |
Mosquito   226 LERSYLTYSHRQRQKSL-------ILVNVVDLVL-------KVVLASVWIGFNSGMTIKPHEVTW 276

  Fly   108 VVLGV--NFRSELVSKHG-WVVYATS---WLAVCVMVLMDI------GLNVYHATSHNDILNPIY 160
            .|..:  ||   |:...| |.::|.:   |.|||..:|:::      ||..    :..:.|  |:
Mosquito   277 SVCCIISNF---LICVLGSWRLFANNYLHWAAVCTWLLLNLQGFLGEGLGF----AEREYL--IW 332

  Fly   161 DAYTLYAIYMFMPVPYLLQP------FVLGSAVTFCYIINYSF--VITAKDDN----QMHSILNE 213
              |.|:.|:    |||.:.|      .:.||....|:::..|.  .:..||.:    ||  |.|.
Mosquito   333 --YVLFIIF----VPYAMLPLPLKWCMIAGSMTAICHLVVTSLNKFLHDKDPSCIVRQM--IANL 389

  Fly   214 AIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERS------LLLSILPAQIA 272
            .:||: :|..|::.:.:.|...|..|::..:.:|      :.|:.|:.      ||.||||.
Mosquito   390 LLYLA-INFAGMYTKYLTDRGQRLAFIETHKAME------HKRESEKEYQRTQRLLDSILPM--- 444

  Fly   273 DRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYT 337
                 .|.|.|.:...:..:|:|||.:       .|:        |:|...::|::|:||:..:|
Mosquito   445 -----FVNNDIRKEMYKSPEQAQVDTQ-------FKK--------LYIYHMDNVSILFADIKGFT 489

  Fly   338 HLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPN----ADHAKCCVDL 398
            .|.:....::||:.|:|||.|||..:|:.:.||||.||||||||:...:.:    .|||.|.|:.
Mosquito   490 ELASKTSAQQLVKILNDLFARFDKIAEDNHCLRIKLLGDCYYCVSMFDSQSWKSRPDHAVCSVET 554

  Fly   399 GLRMIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVH 463
            ||.|||.|:|||.:.::.:|||||:|||.|:.||:|..||.||:||.||.|||.:|:.|..||||
Mosquito   555 GLHMIKAIKDVRCQTNVELDMRIGIHSGSVMCGVLGEKKWHFDVWSNDVVIANHMESGGVPGRVH 619

  Fly   464 VSQKTLSLLDGEYFFEDGTEKAREDPVLQKHGIRTFLIKSLRAPMHDPRRRMRER----QVKKLS 524
            :|:.||..|:..|..|.|...:| |..|:...|:|||||... |:. ||:|:.:|    |.:|.:
Mosquito   620 ISEATLKCLNDTYEVEPGNGGSR-DSHLKMMNIKTFLIKRTE-PLR-PRKRLMDRQSTVQFEKET 681

  Fly   525 EASKA------------NFMHNST---------------LHQYNQVRNQAKLEMCRELDKMPIGR 562
            .|.:|            :...|||               .|.:|...|.....          ..
Mosquito   682 AAMRAGESRFRKDSKTPSITSNSTNTTGTTATCSGGSVVQHNHNNNNNNTTSS----------NN 736

  Fly   563 IQLTKVFRRST----RLTQDEIEEETFRRNISSC------CLFFR-----IRNWEFQYIKEPDVM 612
            ..:||...:||    ..|.|.|.|..| :|::.|      ...||     .|...|...:|.|.|
Mosquito   737 NHITKRTSKSTIHEDETTTDWIPEIPF-KNLNECGGGVNAAESFRDKKHTDREDVFTSTEEVDEM 800

  Fly   613 LKYSIALAWVIYMGLLTIQLLSKDARYHYWYI----------DGT-------------------- 647
            :..||.:.            .:|..|..|.|.          :||
Mosquito   801 IDQSIQIN------------SNKQIRQEYLYTWTLKFKDSSQEGTFCQLREDMFRSNMLCVFVVW 853

  Fly   648 --------------TIILL-----TMLLIVSWYKKLWIMYMSDADVSSPNGRLSGFLFRMSDEMQ 693
                          ||:::     |.||.|.     .|:.|::.....|.     ||.:.|..:.
Mosquito   854 IFIVLCQAVIIPRCTILIVALSITTFLLTVG-----CILVMAEEFSGLPK-----FLQQSSSTLV 908

  Fly   694 RNVVIRVVMYFLIIFSYCAVAIMQVVGCSSDE-----DYADLDPTY------------------- 734
            .:...|.:...|.|......:.|.::.|..:|     |.:.:.|:|
Mosquito   909 HDRSRRTIFVCLTIILMSIASSMGLMMCDLEEVDAVPDRSTVSPSYSYYWQAGGQLNVNSTAITL 973

  Fly   735 -------------------------------------DERV--------QCFHP------WILTN 748
                                                 ||..        .|.||      |:|
Mosquito   974 LRRAVGDALELGALINRTVSETDANTTELVTDELLDHDETTSTPPILHPSCVHPEYVVFTWVL-- 1036

  Fly   749 CM-TLVIGMSFLFTRIPFIIKSCFSALIMIG-YAVLVVSEFNFIYANSPSTNVNFNAKY---SHI 808
            |: :|...:     ::.:::|: |.|:.|:. |:.|::..|..::.       :::.:|   |.:
Mosquito  1037 CLISLATAL-----KLYYLVKT-FMAIAMVACYSFLILLVFEKVFD-------SYDLQYIQASGM 1088

  Fly   809 LL---MIITFGIFHLM----ERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVA 866
            .|   |:|..|:|..|    .|..|..:::|:.||.|..|:..:.........:|:.||||.|||
Mosquito  1089 PLAAQMMILLGVFLTMVTYHARLVEVTSRLDFIWKEQAEKELSNMRSNRHLNDLLIKNILPDHVA 1153

  Fly   867 DFYLSNQLQNELYYEEYDNVAVMFASIKNF--------DTDKIGLRVLNEIICDFDDVLNKYSQS 923
            .:|||.:..:|||.:.::...||||||.||        :..|..:|:|||||.|||.:|.: .:.
Mosquito  1154 TYYLSEERTDELYAKMHELCGVMFASIPNFKDFYSEDIENGKACIRILNEIISDFDSLLEE-PRF 1217

  Fly   924 LRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYG 988
            ..|||||....|||||..|..::...|:
Mosquito  1218 ETVEKIKTVGATYMAASNLCSTKKSHVD------------------------------------- 1245

  Fly   989 NGSNIALDLDLERGQYEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTE 1053
                       ||.:                      |.|..:.||||.:.:.::..|.:...|
Mosquito  1246 -----------ERDE----------------------EAVCDLVEFALAMRQKLQEVNKDAFNT- 1276

  Fly  1054 YEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLRE 1118
                   ..||:|||.|..::||:|..||.||||||.||:||||||||...::||.:.||..|:.
Mosquito  1277 -------FQLRVGISSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWKVQVPDYTAALLQT 1334

  Fly  1119 FNIQCNYRGMTFVKGRGNIPTY-IIG 1143
            ....|..||...|||:|.:.|| ::|
Mosquito  1335 KGYTCVQRGEVNVKGKGLMLTYWVLG 1360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	68/270 (25%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	86/185 (46%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	84/272 (31%)
Adcy8	XP_061499353.1	None