DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ACXD and Npr2

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	NP_446290.1	Gene:	Npr2 / 116564	RGDID:	620851	Length:	1047	Species:	Rattus norvegicus

Alignment Length:	429	Identity:	104/429 - (24%)
Similarity:	186/429 - (43%)	Gaps:	108/429 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VVLGVNF-RSELVSKHGWVVYATSWLAVC------VMVLMDIGLNVYHATSHNDILNPIYDAYTL 165
            :|.|:.| .:.::|.||.:..:.     |      |:.:.|.||..:.:|:..|      |::.|
  Rat   627 LVKGMAFLHNSIISSHGSLKSSN-----CVVDSRFVLKITDYGLASFRSTAEPD------DSHAL 680

  Fly   166 YAIYMFMPVPYLLQPFVLGSAVTFCYIIN---YSFVITAKDDNQMHSILNEAIYLSCVNLLGIFF 227
            ||..:: ..|.||.    |:.:....:..   |||.|          ||.|....|     |.|:
  Rat   681 YAKKLW-TAPELLS----GNPLPTTGMQKADVYSFAI----------ILQEIALRS-----GPFY 725

  Fly   228 RLMRDIA-----------LRTTF---LDRRQYVEENLLL-----------------------RYA 255
            ....|::           .|..|   :||.|..||.:||                       |:.
  Rat   726 LEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFN 790

  Fly   256 RDQERSLLLSIL--PAQIADRLQEDVKNRIERSKQQHQQQSQVDLRRSAD-----------SQTL 307
            ::...|:|.::|  ..|.|:.|::.|:.|         .|:.::.:|.|:           ::.|
  Rat   791 KEGGTSILDNLLLRMEQYANNLEKLVEER---------TQAYLEEKRKAEALLYQILPHSVAEQL 846

  Fly   308 KRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIK 372
            ||..     |:..|..:.||:.::|:|.:|.|:......::|..|:||:..||...:.::|.:::
  Rat   847 KRGE-----TVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVE 906

  Fly   373 FLGDCYYCVAGLANPNAD-HAKCCVDLGLRMIKDIRD--VREKRHLNIDMRIGVHSGDVLSGVIG 434
            .:||.|..|:||...|.. ||.....:.|.::..:..  :|.:.|..:.:|||||:|.|.:||:|
  Rat   907 TIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVG 971

  Fly   435 AAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLSLLD 473
            ....::.::...|:.|:|:|:.|...::|||..|...||
  Rat   972 LKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALD 1010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	50/224 (22%)
		CYCc	254..476	CDD:214485	62/236 (26%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	47/156 (30%)
		CYCc	856..1117	CDD:214485
		Nucleotidyl_cyc_III	878..1142	CDD:299850
Npr2	NP_446290.1	PBP1_NPR_B	26..421	CDD:380607
		PK_GC-A_B	518..792	CDD:270944	42/195 (22%)
		HNOBA	<798..846	CDD:400168	10/56 (18%)
		CYCc	825..1009	CDD:214485	51/188 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900