Protein Alignment ACXD and Adcy9

DIOPT Version :10

• Sequence 1: NP_620469.2
• Gene: ACXD / 38284
• FlyBaseID: FBgn0040507
• Length: 1162
• Species: Drosophila melanogaster
• Sequence 2: NP_001400201.1
• Gene: Adcy9 / 11515
• MGIID: 108450
• Length: 1372
• Species: Mus musculus
• Alignment Length: 1322
• Identity: 316/1322 - (23%)
• Similarity: 536/1322 - (40%)
• Gaps: 364/1322 - (27%)

  Fly    46 NLE---LEDSYDLYMRRLR-----VGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCS 102
            |||   ||..:....||.|     ||:..|...|:.||.:...::::..|.:.::.|      |.
Mouse    99 NLEEACLERCFPQTQRRFRYALFYVGFACLLWSIYFAVHMKSKVIVMVVPALCFLVV------CV 157

  Fly   103 GLVIWVVLGVNFRSELVSKHGWVVYATSWLAVCVMVL-----------------MDIGLNVYHAT 150
            |..::..      ::|.::|    ||.:.||:.::|.                 :|...:...||
Mouse   158 GFFLFTF------TKLYARH----YAWTSLALTLLVFALTLAAQFQVWTPLSGRVDSSNHTLTAT 212

  Fly   151 SHNDILNPIYD----AYTLYAIYMFMPVPYLLQPF--VLGSAV--TFCYIINYSFVITAKDDNQM 207
            ..:..|:.:..    ...|..:|..|.:|..|..|  |:.|.:  ||.|.........:.....:
Mouse   213 PADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVYSVLFETFGYHFRNEDCYPSPGPGAL 277

  Fly   208 H-SILNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQI 271
            | .:|:.|:...|::.:||...:|..:..|:|||...|.:.....|...:..:..::.|::|..|
Mouse   278 HWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRII 342

  Fly   272 ADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNY 336
            ||.|.:......|.|.::|...|..:.::.:..|......:|    ..::..|:|::|:||:|.:
Mouse   343 ADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRP----FKMQQIEEVSILFADIVGF 403

  Fly   337 THLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLR 401
            |.::.......||..|:|||.|||...|:....:|..||||||||||...|.||||.||:::||.
Mouse   404 TKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLG 468

  Fly   402 MIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQ 466
            |||.|....:::...::||:|||:|.||.|::|..:::||:||.||::||.:|..|..|:||:|:
Mouse   469 MIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISE 533

  Fly   467 KTLSLLDGEYFFEDG--TEKAREDPVL-QKHGIRTFLIKSLRAP----------------MHDPR 512
            .|...||..|..|||  .|:..:..|. |..|::|:||...||.                :.|.|
Mouse   534 ATAKYLDDRYEMEDGRVIERLGQSVVADQLKGLKTYLISGQRAKESHCSCAEALLSGFEVIDDSR 598

  Fly   513 RRMRER----------------------------------------------------------- 518
            .....|
Mouse   599 ESSGPRGQGTASPGSVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGTVQNGCQDEPKTSTK 663

  Fly   519 ---------QVKKLSEASKANFMHNSTLH--------QYNQVRNQAKL-EMCRE--------LDK 557
                     .|..|:...||:...||...        :.....:|..| |:.:|        ||:
Mouse   664 VTSSWLLFLSVPLLAHPPKASGGPNSKTQNGLLSPPAEEKLTNSQTSLCEILQEKGRWAGVSLDQ 728

  Fly   558 MPIGRIQLTKVFRRSTRLTQDEIEEET------FRRNISSCCLFFRIRNWEFQY--------IKE 608
            ..:..::...:..::.....|.|:|::      |:..|:...|.|..:..|..|        ||.
Mouse   729 SALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKN 793

  Fly   609 PDVMLKYSIALAWVIYMGLLTIQLLSKDARYHYWYIDGTTIILLTMLLIVSWYKKLWIMYMSDAD 673
            ..|.     ..|...:..||.:.|             .||:.|   :|.::.:.|    |.:.|
Mouse   794 SPVK-----TFASATFSSLLDVFL-------------STTVFL---ILSITCFLK----YGATA- 832

  Fly   674 VSSPNGRLSGFLFRMSDEMQRNVV-IRVVMYFLIIFS---------------YCAVAIMQVVGCS 722
            ...|...|:.|...:..|:...:| ||:|.:...:.:               :|..||:  |...
Mouse   833 TPPPPAALAVFGADLLLEVLSLIVSIRMVFFLEDVMTCTKWLLEWIAGWLPRHCIGAIL--VSLP 895

  Fly   723 SDEDYADLDPTYDERVQCFHPWILTNCMTLVIGMSFL-FTRIPFIIKSCFSALIMIGYAVLV--- 783
            :...|:.:...::..:   |..:.|....||..:.:. |.::...::|..:.::..|..:|:
Mouse   896 ALAVYSHITSEFETNI---HVTMFTGSAVLVAVVHYCNFCQLSSWMRSSLATIVGAGLLLLLHIS 957

  Fly   784 VSEFNFIYANSPSTNVNFNAK----YSHILL------------MIITFGIFHL----MERQTEFI 828
            :.:.:.|..:...:..||:|:    .|.:|.            :|:||.:..|    :.|:.|..
Mouse   958 LCQDSSIVMSPLDSAQNFSAQRNPCNSSVLQDGRRPASLIGKELILTFFLLLLLVWFLNREFEVS 1022

  Fly   829 AKVDYN---------WKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQ-NELYYEEY 883
            .::.|:         .|.|.::.|.|         .||.||:|.|||:     ||: ::.|.:.:
Mouse  1023 YRLHYHGDVEADLHRTKIQSMRDQAD---------WLLRNIIPYHVAE-----QLKVSQTYSKNH 1073

  Fly   884 DNVAVMFASI--------KNFDTDKIGLRVLNEIICDFDDVLNK--YSQSLRVEKIKVANWTYMA 938
            |:..|:||||        :|::..|...|||||:|.|||::|:|  |:.   :||||....||||
Mouse  1074 DSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNS---IEKIKTIGATYMA 1135

  Fly   939 ACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQ 1003
            |.||:.::.::...||
Mouse  1136 ASGLNTAQCQEGGHPQ------------------------------------------------- 1151

  Fly  1004 YEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGIS 1068
                                  |.:|::.|||.::||.:..||...:...::       ||:|.:
Mouse  1152 ----------------------EHLRILFEFAKEMMRVVDDFNNNMLWFNFK-------LRVGFN 1187

  Fly  1069 HGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVKG 1133
            ||...|||:|.:|..|||||:.||:|||||:|||..:|||:|.:...|.:.....:|||...|||
Mouse  1188 HGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKG 1252

  Fly  1134 RGNIPTYII------GIDSEYQ 1149
            :|.:.||:.      |:..::|
Mouse  1253 KGQMKTYLYPKCTDNGVVPQHQ 1274

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:318454	59/271 (22%)
		Nucleotidyl_cyc_III	321..503	CDD:448371	79/184 (43%)
		Nucleotidyl_cyc_III	878..1142	CDD:448371	82/273 (30%)
Adcy9	NP_001400201.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..73
		AcyC	167..576	CDD:441717	126/416 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..375		4/25 (16%)
		Guanylate_cyc	385..573	CDD:425528	79/187 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	596..615		3/18 (17%)
		Guanylate_cyc	1069..1260	CDD:425528	81/271 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1309..1333