DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ACXD and Adcy9

DIOPT Version :9

Sequence 1:	NP_620469.2	Gene:	ACXD / 38284	FlyBaseID:	FBgn0040507	Length:	1162	Species:	Drosophila melanogaster
Sequence 2:	XP_011244107.1	Gene:	Adcy9 / 11515	MGIID:	108450	Length:	1372	Species:	Mus musculus

Alignment Length:	1322	Identity:	316/1322 - (23%)
Similarity:	536/1322 - (40%)	Gaps:	364/1322 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 NLE---LEDSYDLYMRRLR-----VGYLSLFIFIHVAVTVIHTLLLLTTPEIKYVYVDMVAYMCS 102
            |||   ||..:....||.|     ||:..|...|:.||.:...::::..|.:.::.|      |.
Mouse    99 NLEEACLERCFPQTQRRFRYALFYVGFACLLWSIYFAVHMKSKVIVMVVPALCFLVV------CV 157

  Fly   103 GLVIWVVLGVNFRSELVSKHGWVVYATSWLAVCVMVL-----------------MDIGLNVYHAT 150
            |..::..      ::|.::|    ||.:.||:.::|.                 :|...:...||
Mouse   158 GFFLFTF------TKLYARH----YAWTSLALTLLVFALTLAAQFQVWTPLSGRVDSSNHTLTAT 212

  Fly   151 SHNDILNPIYD----AYTLYAIYMFMPVPYLLQPF--VLGSAV--TFCYIINYSFVITAKDDNQM 207
            ..:..|:.:..    ...|..:|..|.:|..|..|  |:.|.:  ||.|.........:.....:
Mouse   213 PADTCLSQVGSFSICIEVLLLLYTVMQLPLYLSLFLGVVYSVLFETFGYHFRNEDCYPSPGPGAL 277

  Fly   208 H-SILNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQI 271
            | .:|:.|:...|::.:||...:|..:..|:|||...|.:.....|...:..:..::.|::|..|
Mouse   278 HWELLSRALLHVCIHAIGIHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRII 342

  Fly   272 ADRLQEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNY 336
            ||.|.:......|.|.::|...|..:.::.:..|......:|    ..::..|:|::|:||:|.:
Mouse   343 ADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRP----FKMQQIEEVSILFADIVGF 403

  Fly   337 THLTTTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLR 401
            |.::.......||..|:|||.|||...|:....:|..||||||||||...|.||||.||:::||.
Mouse   404 TKMSANKSAHALVGLLNDLFGRFDRLCEQTKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLG 468

  Fly   402 MIKDIRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQ 466
            |||.|....:::...::||:|||:|.||.|::|..:::||:||.||::||.:|..|..|:||:|:
Mouse   469 MIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISE 533

  Fly   467 KTLSLLDGEYFFEDG--TEKAREDPVL-QKHGIRTFLIKSLRAP----------------MHDPR 512
            .|...||..|..|||  .|:..:..|. |..|::|:||...||.                :.|.|
Mouse   534 ATAKYLDDRYEMEDGRVIERLGQSVVADQLKGLKTYLISGQRAKESHCSCAEALLSGFEVIDDSR 598

  Fly   513 RRMRER----------------------------------------------------------- 518
            .....|
Mouse   599 ESSGPRGQGTASPGSVSDLAQTVKTFDNLKTCPSCGITFAPKSEAGAEGGTVQNGCQDEPKTSTK 663

  Fly   519 ---------QVKKLSEASKANFMHNSTLH--------QYNQVRNQAKL-EMCRE--------LDK 557
                     .|..|:...||:...||...        :.....:|..| |:.:|        ||:
Mouse   664 VTSSWLLFLSVPLLAHPPKASGGPNSKTQNGLLSPPAEEKLTNSQTSLCEILQEKGRWAGVSLDQ 728

  Fly   558 MPIGRIQLTKVFRRSTRLTQDEIEEET------FRRNISSCCLFFRIRNWEFQY--------IKE 608
            ..:..::...:..::.....|.|:|::      |:..|:...|.|..:..|..|        ||.
Mouse   729 SALLPLRFKNIREKTDAHFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKN 793

  Fly   609 PDVMLKYSIALAWVIYMGLLTIQLLSKDARYHYWYIDGTTIILLTMLLIVSWYKKLWIMYMSDAD 673
            ..|.     ..|...:..||.:.|             .||:.|   :|.::.:.|    |.:.|
Mouse   794 SPVK-----TFASATFSSLLDVFL-------------STTVFL---ILSITCFLK----YGATA- 832

  Fly   674 VSSPNGRLSGFLFRMSDEMQRNVV-IRVVMYFLIIFS---------------YCAVAIMQVVGCS 722
            ...|...|:.|...:..|:...:| ||:|.:...:.:               :|..||:  |...
Mouse   833 TPPPPAALAVFGADLLLEVLSLIVSIRMVFFLEDVMTCTKWLLEWIAGWLPRHCIGAIL--VSLP 895

  Fly   723 SDEDYADLDPTYDERVQCFHPWILTNCMTLVIGMSFL-FTRIPFIIKSCFSALIMIGYAVLV--- 783
            :...|:.:...::..:   |..:.|....||..:.:. |.::...::|..:.::..|..:|:
Mouse   896 ALAVYSHITSEFETNI---HVTMFTGSAVLVAVVHYCNFCQLSSWMRSSLATIVGAGLLLLLHIS 957

  Fly   784 VSEFNFIYANSPSTNVNFNAK----YSHILL------------MIITFGIFHL----MERQTEFI 828
            :.:.:.|..:...:..||:|:    .|.:|.            :|:||.:..|    :.|:.|..
Mouse   958 LCQDSSIVMSPLDSAQNFSAQRNPCNSSVLQDGRRPASLIGKELILTFFLLLLLVWFLNREFEVS 1022

  Fly   829 AKVDYN---------WKRQLIKKQEDALITNDTIKVLLTNILPTHVADFYLSNQLQ-NELYYEEY 883
            .::.|:         .|.|.::.|.|         .||.||:|.|||:     ||: ::.|.:.:
Mouse  1023 YRLHYHGDVEADLHRTKIQSMRDQAD---------WLLRNIIPYHVAE-----QLKVSQTYSKNH 1073

  Fly   884 DNVAVMFASI--------KNFDTDKIGLRVLNEIICDFDDVLNK--YSQSLRVEKIKVANWTYMA 938
            |:..|:||||        :|::..|...|||||:|.|||::|:|  |:.   :||||....||||
Mouse  1074 DSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYNS---IEKIKTIGATYMA 1135

  Fly   939 ACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYGNGSNIALDLDLERGQ 1003
            |.||:.::.::...||
Mouse  1136 ASGLNTAQCQEGGHPQ------------------------------------------------- 1151

  Fly  1004 YEGNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENMQTEYEGSTDYGMLRIGIS 1068
                                  |.:|::.|||.::||.:..||...:...::       ||:|.:
Mouse  1152 ----------------------EHLRILFEFAKEMMRVVDDFNNNMLWFNFK-------LRVGFN 1187

  Fly  1069 HGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALKLREFNIQCNYRGMTFVKG 1133
            ||...|||:|.:|..|||||:.||:|||||:|||..:|||:|.:...|.:.....:|||...|||
Mouse  1188 HGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKG 1252

  Fly  1134 RGNIPTYII------GIDSEYQ 1149
            :|.:.||:.      |:..::|
Mouse  1253 KGQMKTYLYPKCTDNGVVPQHQ 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ACXD	NP_620469.2	AC_N	<42..284	CDD:292831	59/271 (22%)
		CYCc	254..476	CDD:214485	80/221 (36%)
		Nucleotidyl_cyc_III	321..503	CDD:299850	79/184 (43%)
		CYCc	856..1117	CDD:214485	82/271 (30%)
		Nucleotidyl_cyc_III	878..1142	CDD:299850	82/273 (30%)
Adcy9	XP_011244107.1	MFS	<134..260	CDD:391944	26/141 (18%)
		Guanylate_cyc	385..573	CDD:306677	79/187 (42%)
		Guanylate_cyc	1069..1260	CDD:306677	81/271 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6595
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.760