DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ACXD and Adcy8

DIOPT Version :9

Sequence 1:NP_620469.2 Gene:ACXD / 38284 FlyBaseID:FBgn0040507 Length:1162 Species:Drosophila melanogaster
Sequence 2:NP_033753.2 Gene:Adcy8 / 11514 MGIID:1341110 Length:1249 Species:Mus musculus


Alignment Length:1201 Identity:349/1201 - (29%)
Similarity:544/1201 - (45%) Gaps:266/1201 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 NWEWSY-------LVRKCRNLELEDSYDLYM----RRLRVGYLSLFIFIHVAVTVIHTLLLLTTP 87
            |..:||       |....::.:||..|..|.    |:..|....|.:...:.:.|:| |.|.:.|
Mouse   142 NGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLH-LSLASAP 205

  Fly    88 --EIKYVYVDMVAYMCSGLVIWVVLGVNFRSELVSKHGWVVYA--TSWLAVCVMVL---MDIGLN 145
              .:|.:.:...    :|:.:.:...|..|.:..| |.::.|:  .:|:|:...:|   :..|| 
Mouse   206 MDPLKGILLGFF----TGIEVVICALVVVRKDNTS-HTYLQYSGVVTWVAMTTQILAAGLGYGL- 264

  Fly   146 VYHATSHNDILNPIYDAYTLYAIYMFMPVPYLLQPFVLGSAVTFCYIINYSFVITAKDDNQMHSI 210
                  ..|.:.  |..:||:|.|..:|:|  |...:|....|....:....:|.......::.:
Mouse   265 ------LGDGIG--YVLFTLFATYSMLPLP--LTWAILAGLGTSLLQVTLQVLIPRLAVFSINQV 319

  Fly   211 LNEAIYLSCVNLLGIFFRLMRDIALRTTFLDRRQYVEENLLLRYARDQERSLLLSILPAQIADRL 275
            |.:.:...|:|..|||...:.|.|.|..||:.|:.||..|.|.....::..|:||:||..:...:
Mouse   320 LAQVVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEM 384

  Fly   276 QEDVKNRIERSKQQHQQQSQVDLRRSADSQTLKRWRQPDHGTLFIEPHEDVTVLYADVVNYTHLT 340
            ..|:.| :|....|||                       ...::|..:|:|::|:|||..:|:|:
Mouse   385 INDMTN-VEDEHLQHQ-----------------------FHRIYIHRYENVSILFADVKGFTNLS 425

  Fly   341 TTLDVKKLVEALHDLFVRFDIASEEYNVLRIKFLGDCYYCVAGLANPNADHAKCCVDLGLRMIKD 405
            |||..::||..|::||.|||..:.|::.||||.||||||||:||..|..|||.|||::||.|||.
Mouse   426 TTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRRDHAHCCVEMGLSMIKT 490

  Fly   406 IRDVREKRHLNIDMRIGVHSGDVLSGVIGAAKWQFDIWSKDVDIANRLEATGATGRVHVSQKTLS 470
            ||.||.:...::|||||:|||.||.||:|..|||||:||.||||||:||:.|..||:|:|:.||.
Mouse   491 IRFVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLD 555

  Fly   471 LLDGEYFFEDGTEKAREDPVLQKHGIRTFLIK----SLRAPMHDPRRRM-----RERQVKKLSEA 526
            .|:|:|..|:|..|.|.: .|:||.|.|:|||    ||.....|..:..     |.......:|.
Mouse   556 CLNGDYNVEEGHGKERNE-FLRKHNIETYLIKQPEESLLCLPEDIVKESVSCSDRRNSGATFTEG 619

  Fly   527 S------------KANFMHNSTLHQYNQVRNQAKLEM-----CRELDKMPIGRIQLTKVFRRSTR 574
            |            |.|.:...|.:..|.:.|.....:     ..|::|    ||:.|...|...:
Mouse   620 SWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINK----RIEHTIDLRSGDK 680

  Fly   575 LTQDEIEEETFRRNISSCCLFFRIRNWEFQYIKEPDVMLKYSIALAWVIYMGLLTIQLLSKDARY 639
            |.         |.:|....|.|:..:.|.:|.:..|.:.|.::..|:::.:.:..||.|...:|.
Mouse   681 LR---------REHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRL 736

  Fly   640 HYWYIDGTTIILLTMLLIV----SWYKKL---------WI--MYMSDADVSSPNGRLSGFLFRMS 689
            ....|..:.:|:|...|::    ..||.|         ||  .|::                   
Mouse   737 MPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINETYLA------------------- 782

  Fly   690 DEMQRNVVIRVVMYFLIIFSYCAVAIMQVVGCSSDEDYADLDPTYDERVQ----CFHP--WILTN 748
                |||:|    :..|:.::.. |::.::.|..|:.....:.|::....    |.:|  ::.|.
Mouse   783 ----RNVII----FASILINFLG-AVLNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG 838

  Fly   749 CMTLVIGMSFLFTRIPFIIKSCFSALIMIGYAVLVVSEFNFIYANSPSTNVNFN--------AKY 805
            .:.:|....||  |:..::|.....:::..||:|..:    |||....:..|.|        .|.
Mouse   839 VLAMVTCAVFL--RLNSVLKLAVLLIMIAIYALLTET----IYAGLFLSYDNLNHSGEDFLGTKE 897

  Fly   806 SHILLM-IITFGIFHLMERQTEFIAKVDYNWKRQLIKKQEDALITNDTIKVLLTNILPTHVADFY 869
            :.:||| :....:|: ..:|.|:.|::|:.|:.|..::..:.....:..:.:|.||||:|||..:
Mouse   898 ASLLLMAMFLLAVFY-HGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHF 961

  Fly   870 LSNQLQN-ELYYEEYDNVAVMFASIKNF-------DTDKIG---LRVLNEIICDFDDVLNKYSQS 923
            |.....| |||.:.||.|.||||||..|       :.:..|   ||:|||||.|||::|.: .:.
Mouse   962 LEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGE-DRF 1025

  Fly   924 LRVEKIKVANWTYMAACGLDVSRSEQVNAPQMKFRNVSLMPNGRRSRYDGARSSNADGVQRVPYG 988
            ..:||||....||||..||         :|                                   
Mouse  1026 QDIEKIKTIGSTYMAVSGL---------SP----------------------------------- 1046

  Fly   989 NGSNIALDLDLERGQYE---GNVITSGPRISSTHNGSSSNEVVRVMAEFALDLMRTMRRFNTENM 1050
                       |:.|.|   |::.                    .:|:|:|.|..:::..|..:.
Mouse  1047 -----------EKQQCEDKWGHLC--------------------ALADFSLALTESIQEINKHSF 1080

  Fly  1051 QTEYEGSTDYGMLRIGISHGRAMAGVVGISKPHYDIWGNPVNMASRMDSTGVPGQIQVTENTALK 1115
             ..:|       ||||||||..:|||:|..||.|||||..||:|||||||||.|:|||.|.|.|.
Mouse  1081 -NNFE-------LRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLI 1137

  Fly  1116 LREFNIQCNYRGMTFVKG----RGNIPTYII 1142
            |::.....:|||..:|||    .|.|.||.:
Mouse  1138 LKDQGFAFDYRGEIYVKGISEQEGKIKTYFL 1168

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ACXDNP_620469.2 AC_N <42..284 CDD:292831 59/252 (23%)
CYCc 254..476 CDD:214485 99/221 (45%)
Nucleotidyl_cyc_III 321..503 CDD:299850 100/185 (54%)
CYCc 856..1117 CDD:214485 93/274 (34%)
Nucleotidyl_cyc_III 878..1142 CDD:299850 93/280 (33%)
Adcy8NP_033753.2 Involved in ORAI1, STIM1, PPP2CA and PPP2R1A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..180 9/37 (24%)
Involved in AKAP5 and PRKAR2A interaction. /evidence=ECO:0000250|UniProtKB:P40146 1..107
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 14..33
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 38..40
Essential for CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 49..51
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 50..118
AC_N <159..398 CDD:292831 60/256 (23%)
CYCc 364..562 CDD:214485 99/221 (45%)
Guanylate_cyc 403..587 CDD:278633 100/184 (54%)
DUF1053 615..709 CDD:283888 21/106 (20%)
CYCc 942..1146 CDD:214485 94/287 (33%)
Guanylate_cyc 971..1170 CDD:278633 93/282 (33%)
Involved in CALM1 interaction. /evidence=ECO:0000250|UniProtKB:P40146 1107..1249 33/62 (53%)
Required for both calcium stimulation and maintenance of autoinhibition. /evidence=ECO:0000250|UniProtKB:P40146 1198..1213
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1221..1249
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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